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1.发明申请NOVEL SULPHOXIMINE-SUBSTITUTED QUINOLINE AND QUINAZOLINE DERIVATIVES AS KINASE INHIBITORS 失效新型磺酰嘧啶取代的喹啉和喹唑啉衍生物作为激酶抑制剂公开(公告)号：US20090226377A1
公开(公告)日：2009-09-10
申请号：US12126437
申请日：2008-05-23
申请人： Knut EIS , Olaf Prien , Ulrich Lucking , Judith Gunther , Dieter Zopf , Dirk Brohm , Verena Vohringer , Elisabeth Woltering , Hartmut Beck , Mario Lobell , Volkhart Min-Jian Li , Susanne Greschat
发明人： Knut EIS , Olaf Prien , Ulrich Lucking , Judith Gunther , Dieter Zopf , Dirk Brohm , Verena Vohringer , Elisabeth Woltering , Hartmut Beck , Mario Lobell , Volkhart Min-Jian Li , Susanne Greschat
IPC分类号： A61K49/04 , C07D239/94 , A61K31/517 , A61K31/47 , C07D215/44 , A61P9/00 , C12Q1/02 , C12N9/99
CPC分类号： C07D239/86 , C07D215/44 , C07D409/04
摘要： The present invention relates to a quinoline or quinazoline derivative having the general formula (A): in which R3, R4, W, Y and Q are indicated in the description and the claims, the use of the compounds of the general formula (A) for the treatment of various disorders, and the preparation of compounds of the general formula (A).
摘要翻译： 本发明涉及具有通式（A）的喹啉或喹唑啉衍生物：其中R3，R4，W，Y和Q在说明书和权利要求中表示，通式（A）的化合物的用途， 用于治疗各种疾病，以及制备通式（A）的化合物。
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2.发明授权Sulphoximine-substituted quinoline and quinazoline derivatives as kinase inhibitors 失效磺酰亚胺取代的喹啉和喹唑啉衍生物作为激酶抑制剂公开(公告)号：US08003787B2
公开(公告)日：2011-08-23
申请号：US12126437
申请日：2008-05-23
申请人： Knut Eis , Olaf Prien , Ulrich Lücking , Judith Günther , Dieter Zopf , Dirk Brohm , Verena Vöhringer , Elisabeth Woltering , Hartmut Beck , Mario Lobell , Volkhart Min-Jian Li , Susanne Greschat
发明人： Knut Eis , Olaf Prien , Ulrich Lücking , Judith Günther , Dieter Zopf , Dirk Brohm , Verena Vöhringer , Elisabeth Woltering , Hartmut Beck , Mario Lobell , Volkhart Min-Jian Li , Susanne Greschat
IPC分类号： C07D239/86
CPC分类号： C07D239/86 , C07D215/44 , C07D409/04
摘要： The present invention relates to a quinoline or quinazoline derivative having the general formula (A): in which R3, R4, W, Y and Q are indicated in the description and the claims, the use of the compounds of the general formula (A) for the treatment of various disorders, and the preparation of compounds of the general formula (A).
摘要翻译： 本发明涉及具有通式（A）的喹啉或喹唑啉衍生物：其中R3，R4，W，Y和Q在说明书和权利要求中表示，通式（A）的化合物的用途， 用于治疗各种疾病，以及制备通式（A）的化合物。
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公开(公告)号：US20090203582A1
公开(公告)日：2009-08-13
申请号：US12249888
申请日：2008-10-10
申请人： Franz VON NUSSBAUM , Hartmut Beck , Nina Brunner , Rainer Endermann , Johannes Koebberling , Jacques Ragot , Joachim Telser , Joachim Schuhmacher , Sonja Anlauf , Yolanda Cancho-Grande , Susanne Greschat , Hans-Christian Militzer , Guido Schiffer
发明人： Franz VON NUSSBAUM , Hartmut Beck , Nina Brunner , Rainer Endermann , Johannes Koebberling , Jacques Ragot , Joachim Telser , Joachim Schuhmacher , Sonja Anlauf , Yolanda Cancho-Grande , Susanne Greschat , Hans-Christian Militzer , Guido Schiffer
摘要： The invention relates to lysobactin amides and methods for their preparation, as well as their use for manufacturing medicaments for the treatment and/or prophylaxis of diseases, in particular bacterial infectious diseases.
摘要翻译： 本发明涉及溶血酶蛋白酰胺及其制备方法，以及它们用于制备用于治疗和/或预防疾病，特别是细菌感染性疾病的药物的用途。
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4.发明授权Heteroaryl substituted pyrazole derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis 有权用于治疗高增殖性疾病和与血管生成相关的疾病的杂芳基取代的吡唑衍生物公开(公告)号：US08796253B2
公开(公告)日：2014-08-05
申请号：US12600640
申请日：2008-05-08
申请人： Stephen Boyer , Michael Härter , Philip Wickens , Manoj Patel , Ellalahewage Sathyajith Kumarasinghe , Ajay Kumar Bhargava , Karl-Heinz Thierauch , Hartmut Beck , Susanne Greschat , Peter Ellinghaus , Patrick Paulus , Holger Hess-Stumpp
发明人： Stephen Boyer , Michael Härter , Philip Wickens , Manoj Patel , Ellalahewage Sathyajith Kumarasinghe , Ajay Kumar Bhargava , Karl-Heinz Thierauch , Hartmut Beck , Susanne Greschat , Peter Ellinghaus , Patrick Paulus , Holger Hess-Stumpp
IPC分类号： C07D403/04 , C07D413/04 , C07D413/14 , C07D471/04 , C07D491/04
CPC分类号： C07D413/04 , C07D403/04 , C07D413/14 , C07D471/04 , C07D491/04
摘要： This invention relates to novel heteroaryl substituted pyrazole compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and/or angiogenesis disorders, as a sole agent or in combination with other active ingredients or therapeutic measures.
摘要翻译： 本发明涉及新颖的杂芳基取代的吡唑化合物，含有这些化合物的药物组合物，以及这些化合物或组合物用作治疗高增殖和/或血管发生障碍作为唯一试剂或与其它活性成分或治疗措施组合的用途。
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公开(公告)号：US08076285B2
公开(公告)日：2011-12-13
申请号：US12249888
申请日：2008-10-10
申请人： Franz Von Nussbaum , Hartmut Beck , Nina Brunner , Rainer Endermann , Johannes Koebberling , Jacques Ragot , Joachim Telser , Joachim Schuhmacher , Sonja Anlauf , Yolanda Cancho-Grande , Susanne Greschat , Hans-Christian Militzer , Guido Schiffer
发明人： Franz Von Nussbaum , Hartmut Beck , Nina Brunner , Rainer Endermann , Johannes Koebberling , Jacques Ragot , Joachim Telser , Joachim Schuhmacher , Sonja Anlauf , Yolanda Cancho-Grande , Susanne Greschat , Hans-Christian Militzer , Guido Schiffer
摘要： The invention relates to lysobactin amides and methods for their preparation, as well as their use for manufacturing medicaments for the treatment and/or prophylaxis of diseases, in particular bacterial infectious diseases.
摘要翻译： 本发明涉及溶血酶蛋白酰胺及其制备方法，以及它们用于制备用于治疗和/或预防疾病，特别是细菌感染性疾病的药物的用途。
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公开(公告)号：US20130172311A1
公开(公告)日：2013-07-04
申请号：US13696878
申请日：2011-05-03
申请人： Michael Härter , Hartmut Beck , Susanne Greschat-Schade , Peter Ellinghaus , Kerstin Unterschemmann , Joachim Schuhmacher
发明人： Michael Härter , Hartmut Beck , Susanne Greschat-Schade , Peter Ellinghaus , Kerstin Unterschemmann , Joachim Schuhmacher
IPC分类号： A61K31/454 , A61K31/4245 , A61K45/06 , C07D413/14
CPC分类号： A61K31/454 , A61K31/4245 , A61K45/06 , C07D413/14
摘要： The present application relates to novel substituted 1-[3-(heterocyclyl)benzyl]-1H-pyrazole derivatives, to processes for preparation thereof, to use thereof for treatment and/or prevention of diseases and to use thereof for production of medicaments for treatment and/or prevention of diseases, more particularly for treatment and/or prevention of hyperproliferative and angiogenic diseases and those diseases which arise from metabolic adaptation to hypoxic states. Such treatments can be effected in the form of monotherapy or else in combination with other medicaments or further therapeutic measures.
摘要翻译： 本申请涉及新的取代的1- [3-（杂环基）苄基] -1H-吡唑衍生物，其制备方法，其用于治疗和/或预防疾病及其用于生产治疗药物的用途 和/或预防疾病，特别是用于治疗和/或预防过度增生和血管生成疾病以及由代谢适应缺氧状态引起的疾病。 这样的治疗可以以单一疗法的形式进行，或者与其它药物组合或进一步的治疗措施。
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公开(公告)号：US08470811B2
公开(公告)日：2013-06-25
申请号：US13103305
申请日：2011-05-09
申请人： Michael Härter , Hartmut Beck , Susanne Greschat , Peter Ellinghaus , Kerstin Berhörster , Joachim Schuhmacher
发明人： Michael Härter , Hartmut Beck , Susanne Greschat , Peter Ellinghaus , Kerstin Berhörster , Joachim Schuhmacher
IPC分类号： A61K31/4245 , A61K31/454 , C07D413/14
CPC分类号： A61K31/454 , A61K31/4245 , A61K45/06 , C07D413/14
摘要： The present application relates to novel substituted 1-[3-(heterocyclyl)benzyl]-1H-pyrazole derivatives, to processes for preparation thereof, to use thereof for treatment and/or prevention of diseases and to use thereof for production of medicaments for treatment and/or prevention of diseases, more particularly for treatment and/or prevention of hyperproliferative and angiogenic diseases and those diseases which arise from metabolic adaptation to hypoxic states. Such treatments can be effected in the form of monotherapy or else in combination with other medicaments or further therapeutic measures.
摘要翻译： 本申请涉及新的取代的1- [3-（杂环基）苄基] -1H-吡唑衍生物，其制备方法，其用于治疗和/或预防疾病及其用于生产用于治疗的药物的用途 和/或预防疾病，特别是用于治疗和/或预防过度增生和血管生成疾病以及由代谢适应缺氧状态引起的疾病。 这样的治疗可以以单一疗法的形式进行，或者与其它药物组合或进一步的治疗措施。
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公开(公告)号：US20110312930A1
公开(公告)日：2011-12-22
申请号：US13129404
申请日：2009-10-31
申请人： Michael Härter , Hartmut Beck , Peter Ellinghaus , Kerstin Berhörster , Susanne Greschat , Karl-Heinz Thierauch
发明人： Michael Härter , Hartmut Beck , Peter Ellinghaus , Kerstin Berhörster , Susanne Greschat , Karl-Heinz Thierauch
IPC分类号： A61K31/4439 , C07D417/14 , C07D413/04 , A61K31/4545 , A61K31/5377 , A61K31/541 , A61K31/496 , A61K31/4245 , A61K31/454 , A61P35/00 , A61P9/10 , A61P9/00 , A61P9/06 , A61P25/00 , A61P9/12 , A61P13/12 , A61P11/00 , A61P17/06 , A61P3/10 , A61P27/02 , A61P29/00 , A61P7/00 , C07D413/14
CPC分类号： C07D417/14 , C07D413/04 , C07D413/14
摘要： The present application relates to novel aryl compounds with aminoalkyl substituents, to processes for their preparation, to their use for treatment and/or prevention of diseases and to their use for the preparation of medicaments for treatment and/or prevention of diseases, in particular for treatment and/or prevention of hyperproliferative and angiogenic diseases and those diseases which arise from metabolic adaptation to hypoxic states. Such treatments can be carried out as monotherapy or also in combination with other medicaments or further therapeutic measures.
摘要翻译： 本申请涉及具有氨基烷基取代基的新型芳基化合物，其制备方法，其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病的药物的用途，特别是 治疗和/或预防过度增生和血管发生疾病以及由代谢适应缺氧状态引起的疾病。 这样的治疗可以作为单一疗法进行，也可以与其他药物组合进行或进一步的治疗措施。
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9.发明申请HETEROARYL SUBSTITUTED PYRAZOLE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS 有权用于治疗与促血细胞生成相关的高血压疾病和疾病的异氟醚取代的吡唑衍生物公开(公告)号：US20100249085A1
公开(公告)日：2010-09-30
申请号：US12600640
申请日：2008-05-08
申请人： Stephen Boyer , Michael Härter , Philip L. Wickens , Manoj Patel , Ellalahewage Sathyajith Kumarasinghe , Ajay Kumar Bhargava , Karl-Heinz Thierauch , Hartmut Beck , Susanne Greschat , Peter Ellinghaus , Patrick Paulus , Holger Hess-Stumpp
发明人： Stephen Boyer , Michael Härter , Philip L. Wickens , Manoj Patel , Ellalahewage Sathyajith Kumarasinghe , Ajay Kumar Bhargava , Karl-Heinz Thierauch , Hartmut Beck , Susanne Greschat , Peter Ellinghaus , Patrick Paulus , Holger Hess-Stumpp
IPC分类号： A61K31/4245 , C12N5/02 , A61K31/5377 , A61K31/496 , A61K31/437 , A61K31/454 , A61K31/4439 , A61K31/422 , A61K31/423 , A61K31/4184 , A61K31/4178 , C07D403/14 , C07D471/04 , C07D401/14 , C07D413/14 , C07D413/04 , C07D491/048 , C07D487/04 , C07D403/04 , A61K31/4188 , C07D491/056 , A61P35/00 , A61P9/10 , A61P11/00 , A61P13/12 , A61P25/00 , A61P29/00 , A61P17/06 , A61P27/02
CPC分类号： C07D413/04 , C07D403/04 , C07D413/14 , C07D471/04 , C07D491/04
摘要： This invention relates to novel heteroaryl substituted pyrazole compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and/or angiogenesis disorders, as a sole agent or in combination with other active ingredients or therapeutic measures.
摘要翻译： 本发明涉及新颖的杂芳基取代的吡唑化合物，含有这些化合物的药物组合物，以及这些化合物或组合物用作治疗高增殖和/或血管发生障碍作为唯一试剂或与其它活性成分或治疗措施组合的用途。
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公开(公告)号：US20130196964A1
公开(公告)日：2013-08-01
申请号：US13129407
申请日：2009-10-31
申请人： Michael Härter , Hartmut Beck , Peter Ellinghaus , Kerstin Berhörster , Susanne Greschat , Karl-Heinz Thierauch , Frank Süssmeier
发明人： Michael Härter , Hartmut Beck , Peter Ellinghaus , Kerstin Berhörster , Susanne Greschat , Karl-Heinz Thierauch , Frank Süssmeier
IPC分类号： C07D487/04 , A61K31/496 , A61K31/4545 , A61K31/4439 , A61K45/06 , A61K31/498 , A61K31/5377 , A61K31/551 , A61K31/4245 , A61K31/454 , C07D413/14 , A61K31/541
CPC分类号： C07D487/04 , A61K31/4245 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/498 , A61K31/5377 , A61K31/541 , A61K31/551 , A61K45/06 , C07D413/04 , C07D413/14 , C07D471/08 , C07D487/08
摘要： The present application relates to novel aryl compounds with heterocyclic substituents, processes for their preparation, their use for treatment and/or prevention of diseases and their use for the preparation of medicaments for treatment and/or prevention of diseases, in particular for treatment and/or prevention of hyperproliferative and angiogenic diseases and those diseases which arise from metabolic adaptation to hypoxic states. Such treatments can be carried out as monotherapy or also in combination with other medicaments or further therapeutic measures.
摘要翻译： 本申请涉及具有杂环取代基的新型芳基化合物，其制备方法，其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病的药物的用途，特别是用于治疗和/ 或预防过度增生和血管生成疾病以及由代谢适应缺氧状态引起的疾病。 这样的治疗可以作为单一疗法进行，也可以与其他药物组合进行或进一步的治疗措施。
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