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公开(公告)号：US06890295B2
公开(公告)日：2005-05-10
申请号：US10284771
申请日：2002-10-31
CPC分类号： A61B17/3423 , A61B17/3415 , A61B2017/00247 , A61B2017/00561 , A61B2017/306 , A61B2017/3486 , A61B2017/3488 , A61B2018/00392
摘要： Medical devices and methods for accessing an anatomical space of the body and particularly for penetrating the epicardium to access pericardial space and the epicardial surface of the heart in a minimally invasive manner employing suction are disclosed. The distal end of a tubular access sleeve having a sleeve wall surrounding a sleeve access lumen and extending between a sleeve proximal end and a sleeve distal end having a plurality of suction ports arrayed around the sleeve access lumen distal end opening is applied against an outer tissue layer. Suction is applied through the plurality of suction ports to a plurality of portions of the outer tissue layer. A perforation instrument is introduced through the sleeve access lumen to perforate the outer tissue layer to form an access perforation into the anatomic space while the applied suction stabilizes the outer tissue layer, whereby further treatment drugs and devices can be introduced into the anatomic space.
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公开(公告)号：US20050273129A1
公开(公告)日：2005-12-08
申请号：US11111466
申请日：2005-04-21
申请人： Koen Michels , Nicolaas Lokhoff , Matthew Bonner
发明人： Koen Michels , Nicolaas Lokhoff , Matthew Bonner
CPC分类号： A61B17/3423 , A61B17/3415 , A61B2017/00247 , A61B2017/00561 , A61B2017/306 , A61B2017/3486 , A61B2017/3488 , A61B2018/00392
摘要： Medical devices and methods for accessing an anatomical space of the body and particularly for penetrating the epicardium to access pericardial space and the epicardial surface of the heart in a minimally invasive manner employing suction are disclosed. The distal end of a tubular access sleeve having a sleeve wall surrounding a sleeve access lumen and extending between a sleeve proximal end and a sleeve distal end having a plurality of suction ports arrayed around the sleeve access lumen distal end opening is applied against an outer tissue layer. Suction is applied through the plurality of suction ports to a plurality of portions of the outer tissue layer. A perforation instrument is introduced through the sleeve access lumen to perforate the outer tissue layer to form an access perforation into the anatomic space while the applied suction stabilizes the outer tissue layer, whereby further treatment drugs and devices can be introduced into the anatomic space.
摘要翻译： 公开了用于访问身体的解剖空间，特别是用于穿透心外膜以采用抽吸的微创方式进入心包空间和心外膜表面的医疗装置和方法。 管状进入套管的远端具有围绕套管进入腔并且在套筒近端和套筒远端之间延伸的套筒壁，其具有围绕套筒入口腔远端开口排列的多个吸入口，抵靠外部组织 层。 通过多个抽吸端口将吸力施加到外部组织层的多个部分。 通过套管进入腔引入穿孔器械以使外部组织层穿孔，以在被施加的吸力稳定外部组织层时形成进入解剖空间的通路穿孔，从而可以将进一步的治疗药物和装置引入解剖空间。
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公开(公告)号：US6006139A
公开(公告)日：1999-12-21
申请号：US794402
申请日：1997-02-03
CPC分类号： A61N1/057 , A61N1/056 , A61N1/0568
摘要： The present invention is directed to a single pass medical electrical lead. In one embodiment, the lead features a pair of bipolar electrodes positioned along the lead body so that they are positioned in the ventricle and atrium respectively when the lead is implanted. The lead body features a 90 degree bent reinforced section. The bend has a radius of curvature approximately 13 mm and begins approximately 90 mm from the distal end. This curved section is approximately 40 mm in length when straightened. The ventricular electrodes are positioned approximately 28 mm apart. The bend has at least one tine extending therefrom, an electrode is mounted on the tine.
摘要翻译： 本发明涉及单程医用电引线。 在一个实施例中，引线具有沿着引线体定位的一对双极电极，使得当引线被植入时它们分别位于心室和心室中。 引线体具有90度弯曲加强部分。 弯曲部具有大约13mm的曲率半径，并从远端开始大约90mm。 当弯曲时，该弯曲部分的长度约为40毫米。 心室电极间隔约28mm。 弯曲部具有从其延伸的至少一个齿，电极安装在齿上。
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公开(公告)号：US20050085886A1
公开(公告)日：2005-04-21
申请号：US10688229
申请日：2003-10-17
CPC分类号： A61N1/0575 , A61N1/0565
摘要： A distal tip coupled to a body of an implantable medical device includes a canted passageway extending distally from a lumen of the body and an opening terminating the passageway and positioned in proximity to a distal end of the distal tip; a helical fixation element coupled to an elongated member extending within the lumen of the body is adapted to deflect along the canted passageway of the distal tip. The elongated member is adapted to move the helical member through the passageway of the distal tip and out from the opening and to rotate the helical element thereby affixing the helical element into an implant site.
摘要翻译： 联接到可植入医疗装置的主体的远侧末端包括从主体的内腔向远端延伸的倾斜通道和终止该通道并且定位在远侧末端的远端附近的开口; 耦合到在主体的内腔内延伸的细长构件的螺旋固定元件适于沿着远端尖端的倾斜通道偏转。 细长构件适于将螺旋构件移动通过远侧尖端的通道并从开口移出并旋转螺旋元件，从而将螺旋元件固定到植入位置。
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公开(公告)号：US5628778A
公开(公告)日：1997-05-13
申请号：US342976
申请日：1994-11-21
IPC分类号： A61N1/05
CPC分类号： A61N1/057 , A61N1/056 , A61N1/0568
摘要： The present invention is directed to a single pass medical electrical lead. In one embodiment, the lead features a pair of bipolar electrodes positioned along the lead body so that they are positioned in the ventricle and atrium respectively when the lead is implanted. The lead body features a 90 degree bent reinforced section. The bend has a radius of curvature approximately 13 mm and begins approximately 90 mm from the distal end. This curved section is approximately 40 mm in length when straightened. The ventricular electrodes are positioned approximately 28 mm apart. The ventricular cathode electrode is positioned at the distal end of the lead. The atrial electrodes are positioned approximately between 5-35 mm apart, with 28 mm preferred. The atrial anode is located at a position immediately adjacent and proximal the 90 degree bent reinforced section.
摘要翻译： 本发明涉及单程医用电引线。 在一个实施例中，引线具有沿着引线体定位的一对双极电极，使得当引线被植入时它们分别位于心室和心室中。 引线体具有90度弯曲加强部分。 弯曲部具有大约13mm的曲率半径，并从远端开始大约90mm。 当弯曲时，该弯曲部分的长度约为40mm。 心室电极间隔约28mm。 心室阴极位于引线的远端。 心房电极位于大约5-35mm之间，优选28mm。 心房阳极位于紧邻90度弯曲加强部分的位置。
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公开(公告)号：US20060292912A1
公开(公告)日：2006-12-28
申请号：US11468910
申请日：2006-08-31
申请人： Vicki Bjorklund , John Sommer , Douglas Hine , Charles Love , Douglas Heiss , Nicolaas Lokhoff
发明人： Vicki Bjorklund , John Sommer , Douglas Hine , Charles Love , Douglas Heiss , Nicolaas Lokhoff
IPC分类号： H01R11/22
CPC分类号： A61N1/056 , A61N1/057 , A61N2001/058
摘要： An improved medical lead assembly and method of use is provided. The lead assembly includes a lead body, and a spring member positioned adjacent to the lead body. The spring member may be deployed a selectable amount to maintain the lead body in a fixed location within a patient's body. The spring member may be an expandable coil, a mesh structure that is similar to a stent, or any other similar device that may be positioned in a low-profile state during a lead implant procedure. After the lead is positioned at a target destination, the spring member may be deployed an amount that is selected based on the characteristics of the surrounding tissue, including vessel size. According to one aspect of the invention, the lead assembly may provide means for facilitating chronic lead extraction.
摘要翻译： 提供了一种改进的医疗引线组件和使用方法。 引线组件包括引线体和邻近引线体定位的弹簧部件。 弹簧构件可以部署可选择的量以将引线体保持在患者体内的固定位置。 弹簧构件可以是可扩张线圈，类似于支架的网状结构或者在引线植入过程期间可以被定位在低轮廓状态的任何其它类似的装置。 在引线定位在目标目的地之后，弹簧构件可以展开一定量，该量基于包括容器尺寸的周围组织的特性来选择。 根据本发明的一个方面，引线组件可以提供用于促进慢性铅提取的装置。
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7.发明申请公开(公告)号：US20050165324A1
公开(公告)日：2005-07-28
申请号：US10781111
申请日：2004-02-18
申请人： Rogier Receveur , Vincent Larik , Ron Van Der Kruk , Victor Duysens , Richard Houben , Nicolaas Lokhoff , John Feron
发明人： Rogier Receveur , Vincent Larik , Ron Van Der Kruk , Victor Duysens , Richard Houben , Nicolaas Lokhoff , John Feron
IPC分类号： A61B5/00 , A61B5/027 , A61B5/03 , A61B5/107 , A61B8/12 , A61B17/00 , A61B19/00 , A61M25/01 , A61N1/05 , A61B5/02
CPC分类号： A61N1/056 , A61B5/027 , A61B5/036 , A61B5/1459 , A61B8/12 , A61B34/20 , A61B90/06 , A61B90/36 , A61B2017/00088 , A61B2017/00092 , A61B2017/00101 , A61B2017/00115 , A61B2017/00243 , A61B2090/064
摘要： A sensor is provided on a lead and senses various physical parameters that are indicative of a desired anatomical target, such as the coronary sinus. The data from the sensor is used to navigate to the anatomical target and/or confirm that the anatomical target has been reached. In one embodiment, the sensor is a temperature sensor and increased temperature values in and around the coronary sinus are used for navigational purposes.
摘要翻译： 传感器设置在引线上并且感测指示期望的解剖学靶标（例如冠状窦）的各种物理参数。 来自传感器的数据用于导航到解剖目标和/或确认解剖目标已达到。 在一个实施例中，传感器是温度传感器，并且冠状窦内和周围的升高的温度值被用于导航目的。
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公开(公告)号：US6070104A
公开(公告)日：2000-05-30
申请号：US980438
申请日：1997-11-28
IPC分类号： A61N1/05
CPC分类号： A61N1/056
摘要： A transvenous lead specifically designed for multi-chamber electrical stimulation or sensing. In a first embodiment the lead features one or more electrodes for communication with the right atrium as well as one or more electrodes for communication with either or both of the left chambers of the heart. The lead further features structures to simultaneously bring the first electrode into contact with a first chamber, such as the right atrial wall and the second electrode into contact with a particular portion of the coronary sinus wall, to electrically access the left atrium or ventricle. In the preferred embodiment the lead body has varying flex or stiffness characteristics along its length between each of the electrodes. The relation of the varying flex or stiffness characteristics along the lead body length as well as the various linear placements of the electrodes along the lead body length function to simultaneously bring the first electrode into contact with a first desired portion of the heart, such as the right atrial wall, and the second electrode into contact with a second desired portion of the heart, such as a portion of the coronary sinus wall.
摘要翻译： 专为多室电刺激或感应设计的经静脉导管。 在第一实施例中，引线具有用于与右心房连通的一个或多个电极以及用于与心脏的左腔室中的一个或两者连通的一个或多个电极。 引线还具有结构，以同时使第一电极与诸如右心房壁和第二电极的第一腔室接触以与冠状静脉窦壁的特定部分接触以电接入左心房或心室。 在优选实施例中，引线主体沿其长度在每个电极之间具有变化的弯曲或刚度特性。 沿着引线主体长度的变化的弯曲或刚度特性以及电极沿引线体长度的各种线性放置的关系用于同时使第一电极与心脏的第一所需部分接触，例如 右心房壁和第二电极与心脏的第二期望部分接触，例如冠状窦壁的一部分。
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公开(公告)号：US5991668A
公开(公告)日：1999-11-23
申请号：US936991
申请日：1997-09-25
CPC分类号： A61N1/057 , A61N2001/0585
摘要： A transvenous lead specifically designed for coronary sinus implantation. In the preferred embodiment the lead features an electrode which is eccentricity placed along the lead body. Disposed on the opposite side of the lead body is a tine-like member to push or maintain the electrode into contact with the vessel wall. Because the electrode and tine-like member do not entirely block the cross sectional area of the vessel, blood flow through the vessel is not impeded. Through such a configuration electrical stimulation with the tissue comprising the left side of the heart may be accomplished. In alternative embodiments other mechanisms besides tine-like member are used to maintain the contact of the electrode with the vessel wall. In a still further alternative embodiment the eccentricity disposed electrode is positioned instead upon the tip of the tine.
摘要翻译： 专门设计用于冠状窦植入的静脉导管。 在优选实施例中，引线具有沿引线本体放置的偏心的电极。 设置在引线体的相反侧的是齿状部件，以推动或保持电极与血管壁接触。 因为电极和齿状构件不完全阻挡血管的横截面积，所以不会妨碍通过血管的血流。 通过这样的配置，可以实现包括心脏左侧的组织的电刺激。 在替代实施例中，使用除了类似元件之外的其它机构来保持电极与血管壁的接触。 在又一替代实施例中，偏心设置电极被替代地置于尖端。
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公开(公告)号：US06301507B1
公开(公告)日：2001-10-09
申请号：US09487788
申请日：2000-01-20
申请人： Arnoldus Bakels , Nicolaas Lokhoff
发明人： Arnoldus Bakels , Nicolaas Lokhoff
IPC分类号： A61N105
CPC分类号： A61N1/056
摘要： A medical electrical lead having a pre-formed atrial portion assuming a distinctive U-shape is disclosed. The U-shaped atrial portion of the lead is configured and dimensioned to cause at least one atrial electrode disposed thereon to be pushed against the right atrial wall or right atrial sinus wall through pushing forces generated by the lead pressing against regions of the heart located near the superior vena cava or the tricuspid valve, and/or through the action of gravity. The lead provides superior coupling of the atrial electrodes thereof to the walls of the right atrium, and may be configured for single pass DDD stimulation of the right atrium and the right ventricle or other portions of the heart such as the coronary sinus or the great cardiac vein.
摘要翻译： 公开了具有呈现出独特的U形的预形成的心房部分的医用电线。 引线的U形心房部分的构造和尺寸被设计成使得设置在其上的至少一个心房电极被推压抵靠右心房壁或右心房窦壁。 上腔静脉或三尖瓣，和/或通过重力作用。 引线提供了其心房电极与右心房壁的优异耦合，并且可以被配置用于右心房和右心室或心脏的其它部分（例如冠状窦或大心脏）的单程DDD刺激 静脉。
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