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    METHOD OF PRODUCING MEDICAL INSTRUMENT
    1.
    发明申请
    METHOD OF PRODUCING MEDICAL INSTRUMENT 有权
    生产医用仪器的方法

    公开(公告)号：US20100312255A1

    公开(公告)日：2010-12-09

    申请号：US12864074

    申请日：2008-12-17

    申请人： Kohsuke Satake ,  Kazuharu Niwa ,  Ryo Matsushita ,  Yasuhiko Suzuki ,  Hiroko Nomura ,  Kazuhiko Nakada

    发明人： Kohsuke Satake ,  Kazuharu Niwa ,  Ryo Matsushita ,  Yasuhiko Suzuki ,  Hiroko Nomura ,  Kazuhiko Nakada

    IPC分类号： A61F9/007 ,  B05D3/10

    CPC分类号： A61F2/1664 ,  A61F2/0077 ,  A61F2/1675 ,  A61L29/085 ,  A61L31/10 ,  C09D101/14 ,  C09D101/32

    摘要： A method of producing a medical instrument whereby a highly hydrophilic and lubricant coating layer having a high durability can be formed by a simple technique and thus highly hydrophilic and lubricant properties can be imparted to a surface of a medical instrument. An intraocular lens insertion instrument having been subjected to a surface treatment as described above is also provided. The method comprises the steps of: preparing a coating solution by mixing at least a water-insoluble polymer having carboxyl group and a polyfunctional reactive compound with an organic solvent; applying this solution on the surface of the medical instrument; conducting crosslinking; and performing a chemical reaction process whereby the coating layer is made hydrophilic. The intraocular lens insertion instrument is made hydrophilic by forming the coating layer as described above on an inner surface of an insertion tube portion, crosslinking and then performing the chemical reaction process.

    摘要翻译： 通过简单的技术可以形成具有高耐久性的高亲水性和润滑性涂层的医疗器械的制造方法，能够赋予医疗器械表面更高的亲水性和润滑性。 还提供了如上所述进行了表面处理的眼内透镜插入器具。 该方法包括以下步骤：通过将至少具有羧基的水不溶性聚合物和多官能反应性化合物与有机溶剂混合来制备涂布溶液; 将该溶液施用在医疗器械的表面上; 进行交联; 并进行化学反应过程，由此使涂层成为亲水性。 通过在插入管部的内表面上形成如上所述的涂层，进行交联，然后进行化学反应处理，使眼内透镜插入器具亲水。

    Method of producing medical instrument
    2.
    发明授权
    Method of producing medical instrument 有权
    医疗器械生产方法

    公开(公告)号：US08523878B2

    公开(公告)日：2013-09-03

    申请号：US12864074

    申请日：2008-12-17

    申请人： Kohsuke Satake ,  Kazuharu Niwa ,  Ryo Matsushita ,  Yasuhiko Suzuki ,  Hiroko Nomura ,  Kazuhiko Nakada

    发明人： Kohsuke Satake ,  Kazuharu Niwa ,  Ryo Matsushita ,  Yasuhiko Suzuki ,  Hiroko Nomura ,  Kazuhiko Nakada

    IPC分类号： A61F9/00 ,  A61F2/16 ,  A61L33/00

    CPC分类号： A61F2/1664 ,  A61F2/0077 ,  A61F2/1675 ,  A61L29/085 ,  A61L31/10 ,  C09D101/14 ,  C09D101/32

    摘要： A method of producing a medical instrument whereby a highly hydrophilic and lubricant coating layer having a high durability can be formed by a simple technique and thus highly hydrophilic and lubricant properties can be imparted to a surface of a medical instrument. An intraocular lens insertion instrument having been subjected to a surface treatment as described above is also provided. The method includes preparing a coating solution by mixing at least a water-insoluble polymer having carboxyl group and a polyfunctional reactive compound with an organic solvent; applying this solution on the surface of the medical instrument; conducting crosslinking; and performing a chemical reaction process. The coating layer is made hydrophilic. The intraocular lens insertion instrument is made hydrophilic by forming the coating layer as described above on an inner surface of an insertion tube portion, crosslinking and then performing the chemical reaction process.

    摘要翻译： 通过简单的技术可以形成具有高耐久性的高亲水性和润滑性涂层的医疗器械的制造方法，能够赋予医疗器械表面更高的亲水性和润滑性。 还提供了如上所述进行了表面处理的眼内透镜插入器具。 该方法包括通过将至少具有羧基的水不溶性聚合物和多官能反应性化合物与有机溶剂混合来制备涂布溶液; 将该溶液施用在医疗器械的表面上; 进行交联; 并进行化学反应过程。 使涂层成为亲水性。 通过在插入管部的内表面上形成如上所述的涂层，进行交联，然后进行化学反应处理，使眼内透镜插入器具亲水。

    Polymerizable dye and ophthalmic lens containing the same
    5.
    发明授权
    Polymerizable dye and ophthalmic lens containing the same 有权
    可聚合染料和含有它的眼科镜片

    公开(公告)号：US07662937B2

    公开(公告)日：2010-02-16

    申请号：US11910758

    申请日：2006-03-03

    申请人： Kohsuke Satake ,  Kazuharu Niwa

    发明人： Kohsuke Satake ,  Kazuharu Niwa

    IPC分类号： C09B43/18 ,  G02C7/04

    CPC分类号： C09B69/106 ,  C09B43/20

    摘要： A novel benzophenone type polymerizable dye containing a urethane bond and an ophthalmic lens containing the said polymerizable dye are disclosed. The benzophenone type polymerizable dye is shown by the following general formula (1) (wherein R1 and R2 are respectively and independently a hydrogen atom, a hydroxyl group, a carboxylic group, a C1 to C8 alkyl group, a C1 to C8 alkoxy group, a sulfonic acid group or a benzyloxy group, and m and n are respectively and independently an integer of 0 to 18. R3 is any of a polymerizable functional group of a vinyl group, an acryloyl group or a methacryloyl group).

    摘要翻译： 公开了含有氨基甲酸酯键的新型二苯甲酮型可聚合染料和含有所述可聚合染料的眼用透镜。 二苯甲酮型聚合性染料由以下通式（1）表示（其中，R1和R2分别独立地为氢原子，羟基，羧基，C1〜C8烷基，C1〜C8烷氧基， 磺酸基或苄氧基，m和n分别为0〜18的整数.R 3为乙烯基，丙烯酰基或甲基丙烯酰基的聚合性官能团中的任意一种。

    Novel Polymerizable Dye and Ophthalmic Lens Containing the Same
    6.
    发明申请
    Novel Polymerizable Dye and Ophthalmic Lens Containing the Same 有权
    新型可聚合染料和含有其的眼科镜片

    公开(公告)号：US20090082553A1

    公开(公告)日：2009-03-26

    申请号：US11910758

    申请日：2006-03-03

    申请人： Kohsuke Satake ,  Kazuharu Niwa

    发明人： Kohsuke Satake ,  Kazuharu Niwa

    IPC分类号： C09B29/03 ,  G02C7/10

    CPC分类号： C09B69/106 ,  C09B43/20

    摘要： A novel benzophenone type polymerizable dye containing a urethane bond and an ophthalmic lens containing the said polymerizable dye are disclosed. The benzophenone type polymerizable dye is shown by the following general formula (1) (wherein R1 and R2 are respectively and independently a hydrogen atom, a hydroxyl group, a carboxylic group, a C1 to C8 alkyl group, a C1 to C8 alkoxy group, a sulfonic acid group or a benzyloxy group, and m and n are respectively and independently an integer of 0 to 18. R3 is any of a polymerizable functional group of a vinyl group, an acryloyl group or a methacryloyl group).

    摘要翻译： 公开了含有氨基甲酸酯键的新型二苯甲酮型可聚合染料和含有所述可聚合染料的眼用透镜。 二苯甲酮型聚合性染料由以下通式（1）表示（其中，R1和R2分别独立地为氢原子，羟基，羧基，C1〜C8烷基，C1〜C8烷氧基， 磺酸基或苄氧基，m和n分别为0〜18的整数.R 3为乙烯基，丙烯酰基或甲基丙烯酰基的聚合性官能团中的任意一种。

    COLORED CONTACT LENS
    8.
    发明申请
    COLORED CONTACT LENS 有权
    彩色接触镜

    公开(公告)号：US20130093994A1

    公开(公告)日：2013-04-18

    申请号：US13704876

    申请日：2011-06-17

    申请人： Ichiro Ando ,  Yuji Goto ,  Ryo Matsushita ,  Kazuharu Niwa

    发明人： Ichiro Ando ,  Yuji Goto ,  Ryo Matsushita ,  Kazuharu Niwa

    IPC分类号： G02C7/04

    CPC分类号： G02C7/046 ,  B41M5/0047 ,  B41M5/0064 ,  B41M5/0088 ,  G02C7/021 ,  G02C7/04 ,  G02C2202/16

    摘要： Provided is a colored contact lens in which a colored band is disposed at a boundary part between a dark part and a white part of an eye, and a density is gradually changed from the dark part to the white part of the eye such that the density of this colored band decreases from an inner circumference side to an outer circumference side. As a result, a novel colored contact lens is provided with which it is possible to bring out beauty of the white part of the eye, which has been ignored by conventional technology, while an impression is maintained that is as natural and elegant as possible by avoiding an artificial impression such as that found in conventional technology.

    摘要翻译： 提供一种彩色隐形眼镜，其中着色带设置在眼睛的黑暗部分和白色部分之间的边界部分处，并且密度从眼睛的黑暗部分逐渐变为白色部分，使得密度 该彩色带从内周侧向外周侧减小。 结果，提供了一种新颖的彩色隐形眼镜，可以通过传统技术忽视的眼睛的白色部分的美丽，同时保持尽可能自然和优雅的印象 避免了人造印象，例如在传统技术中发现的印象。

    Contact lens
    9.
    发明授权
    Contact lens 有权
    隐形眼镜

    公开(公告)号：US07588334B2

    公开(公告)日：2009-09-15

    申请号：US11597791

    申请日：2004-05-28

    申请人： Ryo Matsushita ,  Kazuharu Niwa ,  Akihisa Sugiyama

    发明人： Ryo Matsushita ,  Kazuharu Niwa ,  Akihisa Sugiyama

    IPC分类号： G02C7/04

    CPC分类号： G02B1/043 ,  C08F220/06 ,  C08F220/24 ,  C08F220/40 ,  C08F222/1006 ,  C08F226/10 ,  C08F230/08

    摘要： A contact lens excellent in optical property, offering favorable feeling during the use thereof, and capable of continuous uses, which is composed of a hard portion in the central part and a soft portion in the periphery of the central part is provided. The contact lens comprising two kinds of polymers and having a hard portion arranged in the central part thereof and a soft portion arranged in the periphery of the central part, wherein a monomer mixture forming the hard portion contains at least one silicone-containing monomer, and the monomer mixture forming the hard portion and a monomer mixture forming the soft portion each contain at least one common hydrophilic monomer.

    摘要翻译： 提供了光学性能优异的接触透镜，在使用中提供良好的感觉，并且能够连续使用，由中心部分的硬部分和中心部分的周边的软部分组成。 隐形眼镜包括两种聚合物，其中心部分具有硬质部分，并且布置在中心部分周围的柔软部分，其中形成硬质部分的单体混合物含有至少一种含硅氧烷的单体，以及 形成硬部分的单体混合物和形成软部分的单体混合物各自含有至少一种常见的亲水性单体。

    Contact Lens
    10.
    发明申请
    Contact Lens 有权
    隐形眼镜

    公开(公告)号：US20070232755A1

    公开(公告)日：2007-10-04

    申请号：US11597791

    申请日：2004-05-28

    申请人： Ryo Matsushita ,  Kazuharu Niwa ,  Akihisa Sugiyama

    发明人： Ryo Matsushita ,  Kazuharu Niwa ,  Akihisa Sugiyama

    IPC分类号： C08F220/28 ,  G02C7/04

    CPC分类号： G02B1/043 ,  C08F220/06 ,  C08F220/24 ,  C08F220/40 ,  C08F222/1006 ,  C08F226/10 ,  C08F230/08

    摘要： A contact lens excellent in optical property, offering favorable feeling during the use thereof, and capable of continuous uses, which is composed of a hard portion in the central part and a soft portion in the periphery of the central part is provided. The contact lens comprising two kinds of polymers and having a hard portion arranged in the central part thereof and a soft portion arranged in the periphery of the central part, wherein a monomer mixture forming the hard portion contains at least one silicone-containing monomer, and the monomer mixture forming the hard portion and a monomer mixture forming the soft portion each contain at least one common hydrophilic monomer.

    摘要翻译： 提供了光学性能优异的接触透镜，在使用中提供良好的感觉，并且能够连续使用，由中心部分的硬部分和中心部分的周边的软部分组成。 隐形眼镜包括两种聚合物，其中心部分具有硬质部分，并且布置在中心部分周围的柔软部分，其中形成硬质部分的单体混合物含有至少一种含硅氧烷的单体，以及 形成硬部分的单体混合物和形成软部分的单体混合物各自含有至少一种常见的亲水性单体。