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公开(公告)号：US4704473A
公开(公告)日：1987-11-03
申请号：US804598
申请日：1985-12-04
申请人： Koichi Nakamura , Kimihiko Hori , Michihiro Hattori , Toru Tejima , Genji Imokawa , Naotake Takaishi
发明人： Koichi Nakamura , Kimihiko Hori , Michihiro Hattori , Toru Tejima , Genji Imokawa , Naotake Takaishi
IPC分类号： C07C65/32 , A61K8/368 , A61Q17/04 , C07C51/00 , C07C51/373 , C07C65/40 , C07C67/00 , C07C59/90
CPC分类号： C07C65/40 , A61K8/368 , A61Q17/04 , C07C51/373
摘要： 4-methoxy-2'-carboxydibenzoylmethane of the following general formula (I) ##STR1## is prepared by reacting p-methoxyacetophenone (III) with phthalic anhydride (II) in accordance with the following reaction equation. ##STR2##The compound (I) and its salts absorb both UV-A and UV-B, and exhibit prominent effects as a ultraviolet absorber for cosmetic formulations such as skin cosmetic formulations and hair cosmetic formulations.
摘要翻译： 通过使对甲氧基苯乙酮（III）与邻苯二甲酸酐（II）按照以下反应式反应制备下列通式（I）的4-甲氧基-2'-羧基二苯甲酰基甲烷。 化合物（I）及其盐吸收UV-A和UV-B两者，并且作为化妆品制剂如皮肤化妆品配方和头发化妆品配方的紫外线吸收剂具有显着的效果。
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公开(公告)号：US4710373A
公开(公告)日：1987-12-01
申请号：US710714
申请日：1985-03-12
申请人： Koichi Nakamura , Michihiro Hattori , Tadashi Tamura , Toru Tejima , Naotake Takaishi , Genji Imokawa , Hajime Hotta
发明人： Koichi Nakamura , Michihiro Hattori , Tadashi Tamura , Toru Tejima , Naotake Takaishi , Genji Imokawa , Hajime Hotta
IPC分类号： A61K8/00 , A61K8/33 , A61K8/36 , A61K8/368 , A61K8/37 , A61K8/39 , A61Q1/00 , A61Q1/02 , A61Q1/04 , A61Q1/06 , A61Q1/12 , A61Q17/04 , A61Q19/08 , C07C65/34 , C07C65/40 , C09K3/00 , A61K7/021 , A61K7/027 , A61K7/42 , A61K9/10
CPC分类号： A61K8/368 , A61Q1/02 , A61Q17/04 , C07C65/34 , C07C65/40 , Y10S424/05 , Y10S514/845 , Y10S514/846 , Y10S514/937 , Y10S514/938 , Y10S514/941
摘要： A composition for application to the skin to protect the skin from the long wavelength ultraviolet ray comprises a dibenzoylmethane derivative of the following general formula ##STR1## in which X represents a hydrogen atom, a monovalent metal cation, an organic cation, a linear or branched alkyl group having from 1 to 24 carbon atoms, or a polyoxyalkylene oxide having 2 or 3 carbon atoms, Y and Z each independently represent a hydroxyl group, a linear or branched alkyl group having from 1 to 24 carbon atoms, or an alkoxy group having from 1 to 24 carbon atoms, or a polyoxyalkylene oxide group having from 2 to 3 carbon atoms, and m and n are independently an integer of from 0 to 3.The composition is adjustable so as to have an optimum HLB balance and has good compatibility with various cosmetic bases. Further, it does not irritate the skin, is difficult to be percutaneously absorbed and shows continued skin-protecting effects.
摘要翻译： 用于皮肤保护皮肤免受长波长紫外线影响的组合物包括以下通式“IMAGE”的二苯甲酰甲烷衍生物，其中X表示氢原子，一价金属阳离子，有机阳离子，直链或支链 具有1至24个碳原子的烷基或具有2或3个碳原子的聚氧化烯，Y和Z各自独立地表示羟基，具有1至24个碳原子的直链或支链烷基或具有 1〜24个碳原子的烷氧基或具有2〜3个碳原子的聚氧亚烷基氧基，m和n分别为0〜3的整数。该组合物是可调节的，以具有最佳的HLB平衡并且具有良好的相容性 与各种化妆品基地。 此外，它不刺激皮肤，难以被皮肤吸收并显示持续的皮肤保护作用。
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3.发明授权P-hydroxycinnamamide derivatives and melanin inhibitor comprising the same 失效β-羟基肉桂酰胺衍生物和包含其的黑色素抑制剂
公开(公告)号：US4981680A
公开(公告)日：1991-01-01
申请号：US380518
申请日：1989-07-17
申请人： Kimihiko Hori , Koichi Nakamura , Michio Kawai , Itsuro Motegi , Genji Imokawa , Naotake Takaishi
发明人： Kimihiko Hori , Koichi Nakamura , Michio Kawai , Itsuro Motegi , Genji Imokawa , Naotake Takaishi
IPC分类号： A61K8/42 , A61K31/16 , A61Q17/04 , C07C233/12 , C07C233/16 , C07C233/67 , C07C233/69 , C07C233/81 , C07C233/83
摘要： A novel melanin inhibitor comprising as an active component a p-hydroxycinnamamide derivative of the following general formula (I) ##STR1## in which R.sub.1 represents a hydrogen atom or a 2-hydroxyethyl group, and R.sub.2 represents a hydroxymethyl group or a carboxyl group.The melanin inhibitor may take various forms such as a lotion, an emulsion, a cream, an ointment, a gel and the like, and it is locally applied onto affected parts such as spots and freckles on the skin, and a pigmental deposition after sunburn.
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4.发明授权P-hydroxycinnamamide derivatives and melanin inhibitor comprising the same 失效β-羟基肉桂酰胺衍生物和包含其的黑色素抑制剂
公开(公告)号：US4876084A
公开(公告)日：1989-10-24
申请号：US76872
申请日：1987-07-23
申请人： Kimihiko Hori , Koichi Nakamura , Michio Kawai , Itsuro Motegi , Genji Imokawa , Naotake Takaishi
发明人： Kimihiko Hori , Koichi Nakamura , Michio Kawai , Itsuro Motegi , Genji Imokawa , Naotake Takaishi
IPC分类号： A61K8/42 , A61K31/16 , A61Q17/04 , C07C233/12 , C07C233/16 , C07C233/67 , C07C233/69 , C07C233/81 , C07C233/83
摘要： A novel melanin inhibitor comprising as an active component a p-hydroxycinnamamide derivative of the following general formula (I) ##STR1## in which R.sub.1 represents a hydrogen atom or a 2-hydroxyethyl group, and R.sub.2 represents a hydroxymethyl group or a carboxyl group.The melanin inhibitor may take various forms such as a lotion, an emulsion, a cream, an ointment, a gel and the like, and it is locally applied onto affected parts such as spots and freckles on the skin, and a pigmental deposition after sunburn.
摘要翻译： 一种新的黑色素抑制剂，其包含作为活性成分的下列通式（I）的对羟基肉桂酰胺衍生物其中R 1表示氢原子或2-羟基乙基，R 2表示羟甲基或 羧基。 黑色素抑制剂可以采用各种形式，例如洗液，乳剂，霜剂，软膏，凝胶等，局部施用于皮肤上的斑点和雀斑等受影响的部位，晒伤后的色素沉积 。
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5.发明授权
公开(公告)号：US4584190A
公开(公告)日：1986-04-22
申请号：US669888
申请日：1984-11-09
申请人： Tohru Tejima , Koichi Nakamura , Michihiro Hattori , Shinichi Masuda , Genji Imokawa , Naotake Takaishi
发明人： Tohru Tejima , Koichi Nakamura , Michihiro Hattori , Shinichi Masuda , Genji Imokawa , Naotake Takaishi
IPC分类号： C07C69/28 , A61K8/00 , A61K8/33 , A61K8/37 , A61K31/235 , A61Q17/04 , C07C69/017 , C07C69/035 , C07C69/24 , C07C69/527 , C07C69/533 , C09K3/00 , A61K7/42
摘要： A chalcone derivative of the formula (I): ##STR1## in which R.sub.1 represents hydrogen or a methyl group, and R.sub.2 represents a linear or branched aliphatic hydrocarbon group having from 2 to 24 carbon atoms.The derivative is effective in protecting the skin when made into ultraviolet absorbing agents including an anti-sunburn oil, since it has the maximum absorbing capacity at a wave length in the vicinity of 350 nm, does not irritate the skin and is highly compatible with a cosmetic base.
摘要翻译： 式（I）的查耳酮衍生物：其中R 1表示氢或甲基，R 2表示具有2至24个碳原子的直链或支链脂族烃基。 该衍生物在制成含有抗晒伤油的紫外线吸收剂时有效保护皮肤，因为其在350nm附近的波长处具有最大吸收能力，不刺激皮肤，并且与 化妆品基地。
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公开(公告)号：US4778823A
公开(公告)日：1988-10-18
申请号：US938954
申请日：1986-12-08
申请人： Akira Kawamata , Shinji Yano , Michihiro Hattori , Shuichi Akazaki , Genji Imokawa , Naotake Takaishi
发明人： Akira Kawamata , Shinji Yano , Michihiro Hattori , Shuichi Akazaki , Genji Imokawa , Naotake Takaishi
CPC分类号： F16K31/18 , A61K8/68 , A61Q19/00 , Y10S516/07
摘要： An external medicament comprises a novel amide derivative represented by the following formula (I). ##STR1## The external medicament is applicable to both a pharmaceutical external medicament and a cosmetic composition, and it provides excellent improving and preventing effects for chapping of the skin.
摘要翻译： 外用药物包含由下式（I）表示的新型酰胺衍生物。 （I）外用药剂适用于药物外用药剂和化妆品组合物，其提供优异的改善和防止皮肤破裂的作用。
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公开(公告)号：US4978523A
公开(公告)日：1990-12-18
申请号：US814172
申请日：1985-12-24
IPC分类号： A61K8/02 , A61K8/37 , A61K8/42 , A61K31/165 , A61Q19/02
CPC分类号： A61K8/37 , A61K31/165 , A61K8/0208 , A61K8/42 , A61Q19/02 , Y10S424/13
摘要： A melanin inhibitor comprising as the reactive component a cinnamic acid derivative of the formula (I) or (II): ##STR1## in which R' represents an acyl group having 2 to 6 carbon atoms, R.sub.1 represents a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, a cycloalkyl group or an alkenyl group, and R.sub.2 represents a hydrogen atom, an alkyl group having 1 to 24 carbon atoms, a cycloalkyl group or an alkenyl group.The melanin inhibitors according to the invention are locally applied to affected portions such as of freckles and pigmentary deposits after sunburn without giving any stimulative or allergic troubles to the skin.
摘要翻译： 一种黑色素抑制剂，其包含式（I）或（II）的肉桂酸衍生物作为反应性成分：其中R'表示具有2至6个碳原子的酰基， R1表示氢原子，碳原子数1〜6的烷基，环烷基或烯基，R2表示氢原子，碳原子数1〜24的烷基，环烷基或烯基。 根据本发明的黑色素抑制剂在晒伤后局部应用于诸如雀斑和色素沉积物的受影响部分，而不给皮肤带来任何刺激性或过敏性麻烦。
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公开(公告)号：US5071971A
公开(公告)日：1991-12-10
申请号：US584739
申请日：1990-09-19
申请人： Shinji Yano , Akira Kawamata , Yoshihiro Minematsu , Shuichi Akazaki , Mitsuko Zama , Genji Imokawa , Naotake Takaishi , Tsuyoshi Ohtomo , Takashi Komori
发明人： Shinji Yano , Akira Kawamata , Yoshihiro Minematsu , Shuichi Akazaki , Mitsuko Zama , Genji Imokawa , Naotake Takaishi , Tsuyoshi Ohtomo , Takashi Komori
CPC分类号： A61K8/42 , A61K8/0212 , A61K8/68 , A61Q19/00 , C07H15/04 , A61Q1/02 , A61Q1/06 , A61Q19/10 , A61Q5/00 , A61Q5/006 , Y10S514/844 , Y10S514/846 , Y10S514/847 , Y10S514/969 , Y10S514/975
摘要： An external skin care preparation comprising a compound represented by the following general formula (I) or (II), or a salt thereof: ##STR1## wherein R.sup.1 means an aliphatic hydrocarbon group having 9-25 carbon atoms, A and B denote specific groups respectively, R.sup.6 and R.sup.7 are individually an aliphatic hydrocarbon group having 10-26 carbon atoms, and R.sup.8 denotes a group --CH.sub.2 CH.sub.2 OH, --CH.sub.2 COOH, or --COCH.sub.3.
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公开(公告)号：US5028416A
公开(公告)日：1991-07-02
申请号：US546276
申请日：1990-06-29
申请人： Shinji Yano , Akira Kawamata , Yoshihiro Minematsu , Shuichi Akazaki , Mitsuko Zama , Genji Imokawa , Naotake Takaishi , Tsuyoshi Ohtomo , Takashi Komori
发明人： Shinji Yano , Akira Kawamata , Yoshihiro Minematsu , Shuichi Akazaki , Mitsuko Zama , Genji Imokawa , Naotake Takaishi , Tsuyoshi Ohtomo , Takashi Komori
CPC分类号： A61K8/42 , A61K8/0212 , A61K8/68 , A61Q19/00 , C07H15/04 , A61Q1/02 , A61Q1/06 , A61Q19/10 , A61Q5/00 , A61Q5/006 , Y10S514/844 , Y10S514/846 , Y10S514/847 , Y10S514/969 , Y10S514/975
摘要： An external skin care preparation comprising a compound represented by the following general formula (I) or (II), or a salt thereof: ##STR1## wherein R.sup.1 means an aliphatic hydrocarbon group having 9-25 carbon atoms, A and B denote specific groups respectively, R.sup.6 and R.sup.7 are individually an aliphatic hydrocarbon group having 10-26 carbon atoms, and R.sup.8 denotes a group --CH.sub.2 CH.sub.2 OH, --CH.sub.2 COOH or --COCH.sub.3.
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公开(公告)号：US4985547A
公开(公告)日：1991-01-15
申请号：US163835
申请日：1988-03-03
申请人： Shinji Yano , Akira Kawamata , Yoshihiro Minematsu , Shuichi Akazaki , Mitsuko Zama , Genji Imokawa , Naotake Takaishi , Tsuyoshi Ohtomo , Takashi Komori
发明人： Shinji Yano , Akira Kawamata , Yoshihiro Minematsu , Shuichi Akazaki , Mitsuko Zama , Genji Imokawa , Naotake Takaishi , Tsuyoshi Ohtomo , Takashi Komori
CPC分类号： A61K8/42 , A61K8/0212 , A61K8/68 , A61Q19/00 , C07H15/04 , A61Q1/02 , A61Q1/06 , A61Q19/10 , A61Q5/00 , A61Q5/006 , Y10S514/844 , Y10S514/846 , Y10S514/847 , Y10S514/969 , Y10S514/975
摘要： An external skin care preparation comprising a compound represented by the following general formula (I) or (II), or a salt thereof: ##STR1## wherein R.sup.1 means an aliphatic hydrocarbon group having 9-25 carbon atoms, A and B denote specific groups respectively, R.sup.6 and R.sup.7 are individually an aliphatic hydrocarbon group having 10-26 carbon atoms, and R.sup.8 denotes a group --CH.sub.2 CH.sub.2 OH, --CH.sub.2 COOH or --COCH.sub.3.
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