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公开(公告)号：US08709780B2
公开(公告)日：2014-04-29
申请号：US13121625
申请日：2009-09-29
IPC分类号： C12N7/02 , A61K39/145
CPC分类号： C07K1/22 , A61K39/00 , A61K39/12 , A61K39/145 , A61K2039/5252 , C07K14/005 , C12N7/00 , C12N2760/16122 , C12N2760/16134 , C12N2760/16151
摘要： The present invention aims to provide a method which enables efficient removal of impurities such as the host proteins from an influenza virus culture liquid by a simple operation, allowing separation and purification of an influenza virus antigen. The method of the present invention for producing a purified influenza virus antigen comprises the step of treating a sample containing an influenza virus with a surfactant, the step of bringing the sample after the treatment into contact with hydroxyapatite in the presence of the surfactant, and the step of recovering a hydroxyapatite-non-adsorbed fraction.
摘要翻译： 本发明的目的在于提供一种能够通过简单的操作从流感病毒培养液中有效去除诸如宿主蛋白质的杂质的方法，从而允许流感病毒抗原的分离和纯化。 本发明的用于制备纯化的流感病毒抗原的方法包括用表面活性剂处理含有流感病毒的样品的步骤，在表面活性剂存在下将处理后的样品与羟基磷灰石接触的步骤， 回收羟基磷灰石非吸附级分的步骤。
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公开(公告)号：US20110182940A1
公开(公告)日：2011-07-28
申请号：US13121625
申请日：2009-09-29
CPC分类号： C07K1/22 , A61K39/00 , A61K39/12 , A61K39/145 , A61K2039/5252 , C07K14/005 , C12N7/00 , C12N2760/16122 , C12N2760/16134 , C12N2760/16151
摘要： The present invention aims to provide a method which enables efficient removal of impurities such as the host proteins from an influenza virus culture liquid by a simple operation, allowing separation and purification of an influenza virus antigen.The method of the present invention for producing a purified influenza virus antigen comprises the step of treating a sample containing an influenza virus with a surfactant, the step of bringing the sample after the treatment into contact with hydroxyapatite in the presence of the surfactant, and the step of recovering a hydroxyapatite-non-adsorbed fraction.
摘要翻译： 本发明的目的在于提供一种能够通过简单的操作从流感病毒培养液中有效去除诸如宿主蛋白质的杂质的方法，从而允许流感病毒抗原的分离和纯化。 本发明的用于制备纯化的流感病毒抗原的方法包括用表面活性剂处理含有流感病毒的样品的步骤，在表面活性剂存在下将处理后的样品与羟基磷灰石接触的步骤， 回收羟基磷灰石非吸附级分的步骤。
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