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公开(公告)号：US20110182940A1
公开(公告)日：2011-07-28
申请号：US13121625
申请日：2009-09-29
CPC分类号： C07K1/22 , A61K39/00 , A61K39/12 , A61K39/145 , A61K2039/5252 , C07K14/005 , C12N7/00 , C12N2760/16122 , C12N2760/16134 , C12N2760/16151
摘要： The present invention aims to provide a method which enables efficient removal of impurities such as the host proteins from an influenza virus culture liquid by a simple operation, allowing separation and purification of an influenza virus antigen.The method of the present invention for producing a purified influenza virus antigen comprises the step of treating a sample containing an influenza virus with a surfactant, the step of bringing the sample after the treatment into contact with hydroxyapatite in the presence of the surfactant, and the step of recovering a hydroxyapatite-non-adsorbed fraction.
摘要翻译： 本发明的目的在于提供一种能够通过简单的操作从流感病毒培养液中有效去除诸如宿主蛋白质的杂质的方法，从而允许流感病毒抗原的分离和纯化。 本发明的用于制备纯化的流感病毒抗原的方法包括用表面活性剂处理含有流感病毒的样品的步骤，在表面活性剂存在下将处理后的样品与羟基磷灰石接触的步骤， 回收羟基磷灰石非吸附级分的步骤。
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公开(公告)号：US08709780B2
公开(公告)日：2014-04-29
申请号：US13121625
申请日：2009-09-29
IPC分类号： C12N7/02 , A61K39/145
CPC分类号： C07K1/22 , A61K39/00 , A61K39/12 , A61K39/145 , A61K2039/5252 , C07K14/005 , C12N7/00 , C12N2760/16122 , C12N2760/16134 , C12N2760/16151
摘要： The present invention aims to provide a method which enables efficient removal of impurities such as the host proteins from an influenza virus culture liquid by a simple operation, allowing separation and purification of an influenza virus antigen. The method of the present invention for producing a purified influenza virus antigen comprises the step of treating a sample containing an influenza virus with a surfactant, the step of bringing the sample after the treatment into contact with hydroxyapatite in the presence of the surfactant, and the step of recovering a hydroxyapatite-non-adsorbed fraction.
摘要翻译： 本发明的目的在于提供一种能够通过简单的操作从流感病毒培养液中有效去除诸如宿主蛋白质的杂质的方法，从而允许流感病毒抗原的分离和纯化。 本发明的用于制备纯化的流感病毒抗原的方法包括用表面活性剂处理含有流感病毒的样品的步骤，在表面活性剂存在下将处理后的样品与羟基磷灰石接触的步骤， 回收羟基磷灰石非吸附级分的步骤。
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公开(公告)号：US20090093414A1
公开(公告)日：2009-04-09
申请号：US11547158
申请日：2005-04-01
申请人： Hitoshi Ikeya , Tadashi Morikawa , Koichi Takahashi , Noriyuki Izutani , Tatsuya Tamura , Akira Okamachi , Takenori Ishizawa , Haruhiko Sato , Yoshinobu Higuchi , Tatsuya Kato , Akie Honma
发明人： Hitoshi Ikeya , Tadashi Morikawa , Koichi Takahashi , Noriyuki Izutani , Tatsuya Tamura , Akira Okamachi , Takenori Ishizawa , Haruhiko Sato , Yoshinobu Higuchi , Tatsuya Kato , Akie Honma
IPC分类号： A61K31/728 , A61K38/03 , C07K2/00 , C07H3/00 , C07D475/00
CPC分类号： C08L5/08 , A61K31/519 , A61K47/61 , A61K47/65 , C07D475/08 , C08B37/0072
摘要： An object of the present invention is to provide a hyaluronic acid-methotrexate conjugate useful as a therapeutic drug for joint disorders. There is provided a hyaluronic acid-methotrexate conjugate useful for the treatment of joint disorders, wherein methotrexate is conjugated with a hydroxy group of hyaluronic acid through a linker containing a peptide chain consisting of 1 to 8 amino acids, and the linker is conjugated with the hyaluronic acid through a carbamate group.
摘要翻译： 本发明的目的是提供可用作关节病的治疗药物的透明质酸 - 甲氨蝶呤缀合物。 提供了可用于治疗关节疾病的透明质酸 - 甲氨蝶呤缀合物，其中甲氨蝶呤通过含有1至8个氨基酸的肽链的接头与透明质酸的羟基缀合，并且接头与 透明质酸通过氨基甲酸酯基团。
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公开(公告)号：US07807675B2
公开(公告)日：2010-10-05
申请号：US11547158
申请日：2005-04-01
申请人： Hitoshi Ikeya , Tadashi Morikawa , Koichi Takahashi , Noriyuki Izutani , Tatsuya Tamura , Akira Okamachi , Takenori Ishizawa , Haruhiko Sato , Yoshinobu Higuchi , Tatsuya Kato , Akie Honma
发明人： Hitoshi Ikeya , Tadashi Morikawa , Koichi Takahashi , Noriyuki Izutani , Tatsuya Tamura , Akira Okamachi , Takenori Ishizawa , Haruhiko Sato , Yoshinobu Higuchi , Tatsuya Kato , Akie Honma
IPC分类号： C07D475/00 , A61K31/715
CPC分类号： C08L5/08 , A61K31/519 , A61K47/61 , A61K47/65 , C07D475/08 , C08B37/0072
摘要： An object of the present invention is to provide a hyaluronic acid-methotrexate conjugate useful as a therapeutic drug for joint disorders. There is provided a hyaluronic acid-methotrexate conjugate useful for the treatment of joint disorders, wherein methotrexate is conjugated with a hydroxy group of hyaluronic acid through a linker containing a peptide chain consisting of 1 to 8 amino acids, and the linker is conjugated with the hyaluronic acid through a carbamate group.
摘要翻译： 本发明的目的是提供一种可用作关节病的治疗药物的透明质酸 - 甲氨蝶呤缀合物。 提供了可用于治疗关节疾病的透明质酸 - 甲氨蝶呤缀合物，其中甲氨蝶呤通过含有1至8个氨基酸的肽链的接头与透明质酸的羟基缀合，并且接头与 透明质酸通过氨基甲酸酯基团。
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