公开(公告)号：US4684719A

公开(公告)日：1987-08-04

申请号：US734198

申请日：1985-05-15

申请人： Yoshihiro Nishikawa ,  Kimihiro Kanemitsu ,  Tatsuhiko Katori ,  Akihiro Shibata ,  Kenichi Kukita

发明人： Yoshihiro Nishikawa ,  Kimihiro Kanemitsu ,  Tatsuhiko Katori ,  Akihiro Shibata ,  Kenichi Kukita

IPC分类号： B01F17/42 ,  A61K31/70 ,  A61K31/7024 ,  A61K31/7028 ,  A61P31/04 ,  A61P35/00 ,  B01F17/56 ,  C07H13/06 ,  C07H15/18 ,  C07H13/02

CPC分类号： C07H13/06

摘要： Disclosed herein are novel .alpha.,.alpha.-trehalose fatty acid diester derivatives useful as carcinostatic substances and surface-activating materials and represented by the general formula (I): ##STR1## wherein R.sup.1 means an alkyl group having 1-21 carbon atoms, R.sup.2 denotes a hydrogen atom or carbobenzoxy group, and R.sup.3 stands for a hydrogen atom or benzyl group. Their preparation processes are also disclosed.

摘要翻译： 本文公开了可用作制癌物质和表面活化材料并由通式（I）表示的新型α，α-海藻糖脂肪酸二酯衍生物：其中R 1表示具有1-21个碳原子的烷基 R2表示氢原子或苄氧羰基，R3表示氢原子或苄基。 还公开了它们的制备方法。

公开(公告)号：US4849512A

公开(公告)日：1989-07-18

申请号：US177483

申请日：1988-04-01

申请人： Minoru Tokizawa ,  Mari Otsuka ,  Kazuhiko Irinoda ,  Seiji Ishizeki ,  Fumio Ishii ,  Kenichi Kukita ,  Hideaki Matsuda ,  Tatsuhiko Katori

发明人： Minoru Tokizawa ,  Mari Otsuka ,  Kazuhiko Irinoda ,  Seiji Ishizeki ,  Fumio Ishii ,  Kenichi Kukita ,  Hideaki Matsuda ,  Tatsuhiko Katori

IPC分类号： C07H13/06 ,  A61K31/70 ,  A61K31/7024 ,  A61P35/00 ,  C07H9/04 ,  C07H13/04

CPC分类号： C07H13/04 ,  C07H9/04

摘要： Derivatives of 3-acylamino-3-deoxyallose represented by the following formula: ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 may be hydrogen atoms, or R.sup.1 and R.sup.2, and R.sup.3 and R.sup.4 may be in combination an isopropylidene group, R.sup.5 represents a hydrogen atom or alkyl group, and R.sup.6 represents a hydrogen atom or acyl group, are disclosed. One of the typical compound 3-deoxy-3-(3-tetradecanoyloxytetradecanoylamino)-1,2:5,6-di-O-isopropylidene- .alpha.-D-allofuranose is prepared by reacting 3-tetradecanoyloxytetradecanoic acid and 3-amino-3-deoxy-1,2:5,6-di-O-isopropylidene-.alpha.-D-allofuranose in the presence of N,N'-dicyclohexylcarbodiimide, as a dehydrating agent. The compound has an excellent carcinostatic activity.

公开(公告)号：US5324735A

公开(公告)日：1994-06-28

申请号：US807856

申请日：1992-01-17

申请人： Akihiro Shibata ,  Hideaki Matsuda ,  Takemitsu Asaoka ,  Masaru Matsumoto ,  Ryuichi Kawahara ,  Tatsuhiko Katori ,  Naokata Taido ,  Tadayuki Kuraishi

发明人： Akihiro Shibata ,  Hideaki Matsuda ,  Takemitsu Asaoka ,  Masaru Matsumoto ,  Ryuichi Kawahara ,  Tatsuhiko Katori ,  Naokata Taido ,  Tadayuki Kuraishi

IPC分类号： C07D215/56 ,  C07D401/04 ,  C07D215/233 ,  A01K31/47

CPC分类号： C07D215/56 ,  C07D401/04

摘要： The present invention relates to a quinolone carboxylic acid derivative represented by the following the formula (I), ##STR1## wherein R.sub.1 is a lower alkyl group, R.sub.2 is a hydrogen atom or a lower alkyl group, R.sub.3 is a hydrogen atom or a halogen atom, R.sub.4 and R.sub.5 together form a five- or six-membered ring which may contain hetero atoms or may have substituents, provided that a compound wherein R.sub.1 is a methyl group, R.sub.2 and R.sub.3 are hydrogen atom and ##STR2## is a piperazinyl group is excluded; or a salt thereof; to an antimicrobial agent comprising the same as an effective component; and to an intermediate for producing same.

摘要翻译： PCT No.PCT / JP90 / 00425 Sec。 371日期：1992年1月17日 102（e）日期1992年1月17日PCT 1990年3月29日PCT公布。 出版物WO91 / 01308 1991年2月7日。本发明涉及由下式（I）表示的喹诺酮羧酸衍生物，其中R1是低级烷基，R2是氢原子或低级烷基 基团，R 3是氢原子或卤素原子，R 4和R 5一起形成可含有杂原子或可以具有取代基的五元或六元环，条件是其中R 1是甲基，R 2和R 3是 氢原子和是不包括的哌嗪基; 或其盐; 涉及包含其作为有效成分的抗微生物剂; 和用于生产它的中间体。

公开(公告)号：US4814436A

公开(公告)日：1989-03-21

申请号：US938883

申请日：1986-12-08

申请人： Akihiro Shibata ,  Hideaki Matsuda ,  Hidehiko Kohya ,  Tatsuhiko Katori

发明人： Akihiro Shibata ,  Hideaki Matsuda ,  Hidehiko Kohya ,  Tatsuhiko Katori

IPC分类号： C07H13/04 ,  A61K31/70 ,  A61K31/7024 ,  A61K31/7028 ,  A61P35/00 ,  C07H13/06 ,  C07H15/18 ,  C07H13/02 ,  A61K31/715

CPC分类号： C07H13/06 ,  C07H15/18

摘要： Derivatives of .alpha.,.alpha.-trehalose-6,6'-fatty acid diester having phosphoric ester groups in the molecule which are useful as a carcinostatic agent. One of the derivatives may be prepared by reacting diphenylphosphoryl chloridate with a derivative of 2,3,2',3'-tetra-O-benzyl-.alpha.,.alpha.-trehalose-6,6'-fatty acid diester. Another derivative may be obtained by substituting benzyl groups at 2,3,2',3' positions of trehalose with hydrogen atoms.

摘要翻译： 在分子中具有磷酸酯基的α，α - 海藻糖-6,6'-脂肪酸二酯的衍生物可用作制癌剂。 衍生物之一可以通过二苯基磷酰氯与2,3,2'，3'-四-O-苄基-α，α-脱水-6,6'-脂肪酸二酯的衍生物反应来制备。 通过用氢原子代替海藻糖的2,3,2'，3'位的苄基可以得到另一种衍生物。

公开(公告)号：US4942172A

公开(公告)日：1990-07-17

申请号：US196431

申请日：1988-05-20

申请人： Hitoshi Nakazawa ,  Mari Ohtsuka ,  Hideaki Matsuda ,  Tatsuhiko Katori ,  Kazuhiko Irinoda

发明人： Hitoshi Nakazawa ,  Mari Ohtsuka ,  Hideaki Matsuda ,  Tatsuhiko Katori ,  Kazuhiko Irinoda

IPC分类号： C07D339/06 ,  A61K31/385 ,  A61P1/16

CPC分类号： A61K31/385 ,  Y10S514/894

摘要： A method of curing or alleviating hepatic disease comprising administrating to the patient 1,3-dithiole-2-thione or 1,3-dithiolane-2-thione is disclosed. Adminstration of the compound can be made in various dosing forms, including tablets, granules, powders, capsules, suspensions, injections, and suppositories. Normal dosing amount can be determined from the range of 0.01 to 50 mg/kg/day for oral administration, and 0.002 to 10 mg/kg/day for injection or other forms of administration.

公开(公告)号：US4564615A

公开(公告)日：1986-01-14

申请号：US441177

申请日：1982-11-12

申请人： Hideaki Matsuda ,  Ryohta Tatezaki ,  Hiroyuki Mizuno ,  Tatsuhiko Katori

发明人： Hideaki Matsuda ,  Ryohta Tatezaki ,  Hiroyuki Mizuno ,  Tatsuhiko Katori

IPC分类号： C07D513/04 ,  A61K31/535

CPC分类号： C07D513/04 ,  Y10S514/825 ,  Y10S514/885 ,  Y10S514/892

摘要： An immunoactivator comprising an effective amount of a thiazolobenzoxazine derivative of the formula, or its salt ##STR1## wherein R.sup.1 represents a hydrogen atom, carboxyl group or lower alkoxycarbonyl group, R.sup.2 represents a substituted or unsubstituted phenyl group, lower alkyl group or furyl group, and R.sup.3 represents a hydrogen atom or lower alkoxy group.

摘要翻译： 包含有效量的下式的噻唑并恶嗪衍生物或其盐，其中R1表示氢原子，羧基或低级烷氧基羰基，R2表示取代或未取代的苯基，低级烷基或呋喃基， 并且R 3表示氢原子或低级烷氧基。

公开(公告)号：US5082948A

公开(公告)日：1992-01-21

申请号：US484368

申请日：1990-02-22

申请人： Minoru Tokizawa ,  Takemitsu Asaoka ,  Hideaki Matsuda ,  Tatsuhiko Katori

发明人： Minoru Tokizawa ,  Takemitsu Asaoka ,  Hideaki Matsuda ,  Tatsuhiko Katori

IPC分类号： C07D233/60 ,  C07D521/00

CPC分类号： C07D249/08 ,  C07D231/12 ,  C07D233/56

摘要： Novel imidazole derivatives and their acid adducts are disclosed. The imidazole derivatives are represented by formula: ##STR1## wherein R.sub.1 represents an alkyl group, R.sub.2 represents a hydrogen atom, an alkyl group which may have a substituent, or an aralkyl group which may have a substituent, provided that R.sub.1 and R.sub.2 are not both methyl groups at the same time. They have strong antimicrobial activity, especially against those fungi belonging to the genera Candida, Trichophyton, Microsporum, and Epidermorphyton, as well as against Gram-positive bacteria, and thus is useful as an antimicrobial agent.

公开(公告)号：US5047428A

公开(公告)日：1991-09-10

申请号：US365368

申请日：1989-06-13

申请人： Yoshikuni Itoh ,  Hiroyuki Mizuno ,  Chikako Kiyohara ,  Susumu Sato ,  Tatsuhiko Katori

发明人： Yoshikuni Itoh ,  Hiroyuki Mizuno ,  Chikako Kiyohara ,  Susumu Sato ,  Tatsuhiko Katori

IPC分类号： A61K31/195 ,  A61K31/198 ,  A61P11/10 ,  C07C323/58

CPC分类号： A61K31/195 ,  Y10S514/855

摘要： An expectorant comprising a hydroxyalkylcysteine derivative of the following formula (I) is disclosed. ##STR1## wherein n represents an integer of 1 to 4. The expectorant is stabile, has little side effects and toxicity, and exhibits an excellent expectorant effect.

公开(公告)号：US4977275A

公开(公告)日：1990-12-11

申请号：US333239

申请日：1989-04-05

申请人： Hiroshi Hasegawa ,  Kinichi Mogi ,  Noriaki Shioiri ,  Susumu Sato ,  Tatsuhiko Katori

发明人： Hiroshi Hasegawa ,  Kinichi Mogi ,  Noriaki Shioiri ,  Susumu Sato ,  Tatsuhiko Katori

IPC分类号： A61K31/40 ,  A01N43/36 ,  A61K31/4025 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/4433 ,  A61P17/00 ,  C07D207/34 ,  C07D401/12 ,  C07D409/12

CPC分类号： C07D207/34

摘要： A pyrrole derivative having excellent anti-microbial activities is disclosed. This compound is represented by the following formula (I): ##STR1## wherein X.sub.1 and X.sub.2 are the same or different and mean individually a halogen atom, R.sub.1 denotes an alkyl, cycloalkyl, haloalkyl, alkenyl, substituted or unsubstituted phenyl, substituted or unsubstituted aralkyl group or a group --COR.sub.3 in which R.sub.3 is an alkyl group having at least five carbon atoms or a cycloalkyl, haloalkyl, alkenyl, substituted or unsubstituted phenyl, substituted or unsubstituted aralkyl, or heterocyclic group, and R.sub.2 stands for a hydrogen or halogen atom or an alkyl group, with a proviso that R.sub.1 is other than a hydrogen atom or methyl group when X.sub.1, X.sub.2 and R.sub.2 are each a bromine atom.

公开(公告)号：US4968825A

公开(公告)日：1990-11-06

申请号：US418169

申请日：1989-10-06

申请人： Koichi Yokoi ,  Kinichi Mogi ,  Kazuhiko Irinoda ,  Hidehiko Kohya ,  Susumu Sato ,  Tatsuhiko Katori

发明人： Koichi Yokoi ,  Kinichi Mogi ,  Kazuhiko Irinoda ,  Hidehiko Kohya ,  Susumu Sato ,  Tatsuhiko Katori

IPC分类号： C07F15/00

CPC分类号： C07F15/0093

摘要： A platinum complex having a superior antitumor activity is disclosed. The platinum complex has a structure represented by the formula: ##STR1## wherein A and B independently represent a lower alkanoyloxy group which may have a halogen atom substituent, or in combination represent a group: ##STR2## wherein R.sub.1 and R.sub.2 independently represent a hydrogen atom, a hydroxyl group, or a lower alkyl group, or in combination with each other and with the adjacent carbon atom a cyclobutane ring, and R.sub.3 represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a halogen atom, a sulfo group, or nitro group.