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公开(公告)号：US09738906B2
公开(公告)日：2017-08-22
申请号：US14117465
申请日：2012-05-11
申请人： Koji Eto , Hiromitsu Nakauchi , Naoya Takayama , Sou Nakamura
发明人： Koji Eto , Hiromitsu Nakauchi , Naoya Takayama , Sou Nakamura
CPC分类号： C12N15/85 , A61K35/19 , C12N5/0644 , C12N2501/165 , C12N2501/48 , C12N2506/02
摘要： An object of the present invention is to provide a method of promoting polyploidization of megakaryocytes and thereby producing highly polyploidized megakaryocytes, a method of efficiently producing platelets from polyploidized megakaryocytes, and the like. The present invention provides a method of producing polyploidized megakaryocytes comprising a step of forcing expression of an apoptosis suppressor gene in megakaryocytes before polyploidization and culturing the resulting cells.
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公开(公告)号：US09200254B2
公开(公告)日：2015-12-01
申请号：US13496321
申请日：2010-09-15
申请人： Koji Eto , Naoya Takayama , Sou Nakamura , Hiromitsu Nakauchi
发明人： Koji Eto , Naoya Takayama , Sou Nakamura , Hiromitsu Nakauchi
CPC分类号： C12N5/0641 , A61K35/00 , C12N5/0644 , C12N2501/40 , C12N2501/48 , C12N2501/60 , C12N2501/606 , C12N2506/02 , C12N2506/45
摘要： The present invention has an object of providing a method for producing specific cells by amplifying cells in a desired differentiation stage. The present invention provides a method for producing specific cells by inducing differentiation of cells, wherein an oncogene is forcibly expressed in cells in a desired differentiation stage to amplify the cells in the desired differentiation stage. The present invention also provides a method for producing specific cells, wherein oncogene-induced senescence (OIS) which is induced by the oncogene expressed in the cells in the desired differentiation stage is suppressed.
摘要翻译： 本发明的目的是提供通过在期望的分化阶段中扩增细胞来产生特定细胞的方法。 本发明提供通过诱导细胞分化来产生特异性细胞的方法，其中癌细胞在期望的分化阶段的细胞中被强制表达以扩增所需分化阶段的细胞。 本发明还提供了一种制备特定细胞的方法，其中抑制了在所需分化阶段中在细胞中表达的癌基因诱导的致癌基因诱导的衰老（OIS）。
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公开(公告)号：US20140127815A1
公开(公告)日：2014-05-08
申请号：US14117465
申请日：2012-05-11
申请人： Koji Eto , Hiromitsu Nakauchi , Naoya Takayama , Sou Nakamura
发明人： Koji Eto , Hiromitsu Nakauchi , Naoya Takayama , Sou Nakamura
CPC分类号： C12N15/85 , A61K35/19 , C12N5/0644 , C12N2501/165 , C12N2501/48 , C12N2506/02
摘要： An object of the present invention is to provide a method of promoting polyploidization of megakaryocytes and thereby producing highly polyploidized megakaryocytes, a method of efficiently producing platelets from polyploidized megakaryocytes, and the like. The present invention provides a method of producing polyploidized megakaryocytes comprising a step of forcing expression of an apoptosis suppressor gene in megakaryocytes before polyploidization and culturing the resulting cells.
摘要翻译： 本发明的目的是提供一种促进巨核细胞多倍体化，从而产生高度多倍体的巨核细胞的方法，一种从多倍体巨核细胞中有效产生血小板的方法等。 本发明提供多倍体巨核细胞的制造方法，其特征在于，在多倍体化前，在巨核细胞中强制表达凋亡抑制基因的步骤，培养所得细胞。
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公开(公告)号：US20120238023A1
公开(公告)日：2012-09-20
申请号：US13496321
申请日：2010-09-15
申请人： Koji Eto , Naoya Takayama , Sou Nakamura , Hiromitsu Nakauchi
发明人： Koji Eto , Naoya Takayama , Sou Nakamura , Hiromitsu Nakauchi
CPC分类号： C12N5/0641 , A61K35/00 , C12N5/0644 , C12N2501/40 , C12N2501/48 , C12N2501/60 , C12N2501/606 , C12N2506/02 , C12N2506/45
摘要： The present invention has an object of providing a method for producing specific cells by amplifying cells in a desired differentiation stage. The present invention provides a method for producing specific cells by inducing differentiation of cells, wherein an oncogene is forcibly expressed in cells in a desired differentiation stage to amplify the cells in the desired differentiation stage. The present invention also provides a method for producing specific cells, wherein oncogene-induced senescence (OIS) which is induced by the oncogene expressed in the cells in the desired differentiation stage is suppressed.
摘要翻译： 本发明的目的是提供通过在期望的分化阶段中扩增细胞来产生特定细胞的方法。 本发明提供通过诱导细胞分化来产生特异性细胞的方法，其中癌细胞在期望的分化阶段的细胞中被强制表达以扩增所需分化阶段的细胞。 本发明还提供了一种制备特定细胞的方法，其中抑制了在所需分化阶段中在细胞中表达的癌基因诱导的致癌基因诱导的衰老（OIS）。
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公开(公告)号：US5701349A
公开(公告)日：1997-12-23
申请号：US476332
申请日：1995-06-07
申请人： Hisashi Sano , Sou Nakamura , Hideshi Sawada , Shuichi Adachi , Hideki Kasuya
发明人： Hisashi Sano , Sou Nakamura , Hideshi Sawada , Shuichi Adachi , Hideki Kasuya
CPC分类号： G10K11/1786 , G10K2210/106 , G10K2210/12821 , G10K2210/3026 , G10K2210/3027 , G10K2210/3028 , G10K2210/3053
摘要： An active vibration controller includes acceleration detectors for generating output signals on the basis of vibrations of a vehicle, speakers provided in a vehicle's cabin, microphones provided in the vehicle's cabin for receiving generated sounds from the speakers and road noises generated on the basis of running of the vehicle, and adaptive digital filters using output signals from the acceleration detectors as inputs for controlling filter factors on the basis of an RLS algorithm to minimize levels of output signals from the microphones in response to output signals from the microphones and output signals from the acceleration detectors through use of a transfer function matched to the transfer function of the vehicle's cabin in a sound field between the speakers and the microphones. The controller minimized levels of output signals from the microphones by developing an applied output signal to the speakers. Thus parameters of the filter factors are adaptively updated in accordance with identified system characteristics, providing satisfactory estimation accuracy, and quick convergence to changed sensed noise to silence road noise in the vehicle's cabin.
摘要翻译： 主动振动控制器包括加速度检测器，用于根据车辆的振动，设置在车厢内的扬声器产生输出信号，设置在车厢内的麦克风用于从扬声器接收产生的声音，并基于运行中产生的道路噪声 车辆和使用来自加速度检测器的输出信号的自适应数字滤波器作为用于基于RLS算法控制滤波器因子的输入，以响应于来自麦克风的输出信号和来自加速度的输出信号来最小化来自麦克风的输出信号的水平 通过在扬声器和麦克风之间的声场中使用与车辆舱的传递功能相匹配的传递函数的检测器。 控制器通过向扬声器开发施加的输出信号来最小化来自麦克风的输出信号的水平。 因此，根据所识别的系统特性，提供令人满意的估计精度以及快速收敛以改变感测到的噪声以使车厢内的道路噪声沉默，自适应地更新滤波因子的参数。
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公开(公告)号：US07742645B2
公开(公告)日：2010-06-22
申请号：US11550436
申请日：2006-10-18
申请人： Sou Nakamura
发明人： Sou Nakamura
CPC分类号： H04N19/436 , H04N19/13 , H04N19/63 , H04N19/647
摘要： The encoding device of the present invention comprises a type determination unit inputs each bit of the weblet co-efficient in a depth direction in parallel and determines type information indicating which the bit is, the first “1” bit when viewed from an MSB side, a bit located further on the MSB side than the first “1” bit, a bit located further on an LSB side than the first “1” bit, a buffer unit for buffering the determined type information of each bit for each bit depth and a pass determination unit for determining pass information of a type information to process, of a plurality of pieces of type information, based on the plurality of pieces of buffered type information of the same depth.
摘要翻译： 本发明的编码装置包括类型确定单元，并行地输入深度方向上的每一比特的高密度比特，并且确定表示该比特是哪一个的类型信息，从MSB侧观察第一个“1”比特， 位于MSB侧比第一“1”位进一步位，位于比第一“1”位更靠在LSB侧的位，缓冲单元，用于缓冲每个比特深度的每个比特的确定类型信息，以及 通过确定单元，用于基于相同深度的多条缓冲类型信息确定多个类型信息的处理类型信息的通过信息。
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