公开(公告)号：US20080108837A1

公开(公告)日：2008-05-08

申请号：US10579162

申请日：2004-11-09

申请人： Koji Nakanishi ,  Stanislav Jaracz ,  Shahid Malik ,  Hideki Ishii ,  Sergei V. Dzyuba

发明人： Koji Nakanishi ,  Stanislav Jaracz ,  Shahid Malik ,  Hideki Ishii ,  Sergei V. Dzyuba

IPC分类号： C07D407/14

CPC分类号： C07D493/22

摘要： The subject invention provides a method for separating a terpene trilactone from Ginkgo biloba plant material or from an extract of Ginkgo biloba comprising a mixture of terpene trilactones, the process comprising the steps of:a) subjecting the Ginkgo biloba plant material or the extract to column chromatography with an appropriate solvent system to produce at least a first fraction containing the terpene trilactone bilobalide, a second fraction eluted after the first fraction containing the terpene trilactones GA and GB, and a third fraction eluted after the second fraction containing at least a preponderance of the terpene trilactones GC and GJ; andb) alkylating the terpene trilactone GB of the second fraction so as to produce a first mixture including terpene trilactone GA and alkylated terpene trilactone GB; or alkylating the terpene trilactone GC of the third fraction so as produce a second mixture including terpene trilactone GJ and alkylated terpene trilactone GC, so as to thereby isolate a terpene trilactone.

摘要翻译： 本发明提供了从银杏植物材料或银杏提取物中分离萜烯三内酯的方法，其中包括萜内三聚物的混合物，该方法包括以下步骤：a）将银杏植物材料或提取物经柱 用适当的溶剂体系进行色谱以产生至少一种含有萜烯三内酰亚叶内酰脲的第一级分，在含有萜烯三内酰胺GA和GB的第一级分之后洗脱的第二级分，以及第二级分洗脱的第三级分，其中至少含有 萜类三内酯GC和GJ; 和b）将第二级分的萜烯三内酯GB烷基化，以产生包含萜内酯GA和烷基化萜三内酯GB的第一混合物; 或烷基化第三级分的萜烯三内酰胺GC，从而产生包括萜内酯GJ和烷基化萜三内酰胺GC的第二混合物，从而分离萜烯三内酯。

公开(公告)号：US07763741B2

公开(公告)日：2010-07-27

申请号：US10579162

申请日：2004-11-09

申请人： Koji Nakanishi ,  Stanislav Jaracz ,  Shahid Malik ,  Hideki Ishii ,  Sergei V. Dzyuba

发明人： Koji Nakanishi ,  Stanislav Jaracz ,  Shahid Malik ,  Hideki Ishii ,  Sergei V. Dzyuba

IPC分类号： C07D407/00

CPC分类号： C07D493/22

摘要： The subject invention provides a method for separating a terpene trilactone from Ginkgo biloba plant material or from an extract of Ginkgo biloba comprising a mixture of terpene trilactones, the process comprising the steps of: a) subjecting the Ginkgo biloba plant material or the extract to column chromatography with an appropriate solvent system to produce at least a first fraction containing the terpene trilactone bilobalide, a second fraction eluted after the first fraction containing the terpene trilactones GA and GB, and a third fraction eluted after the second fraction containing at least a preponderance of the terpene trilactones GC and GJ; and b) alkylating the terpene trilactone GB of the second fraction so as to produce a first mixture including terpene trilactone GA and alkylated terpene trilactone GB; or alkylating the terpene trilactone GC of the third fraction so as produce a second mixture including terpene trilactone GJ and alkylated terpene trilactone GC, so as to thereby isolate a terpene trilactone.

摘要翻译： 本发明提供了从银杏植物材料或银杏提取物中分离萜烯三内酯的方法，其中包括萜内三聚物的混合物，该方法包括以下步骤：a）将银杏植物材料或提取物经柱 用适当的溶剂体系进行色谱以产生至少一种含有萜烯三内酰亚叶内酰脲的第一级分，在含有萜烯三内酰胺GA和GB的第一级分洗脱的第二级分，以及第二级分洗脱的第三级分，其中至少含有 萜类三内酯GC和GJ; 和b）将第二级分的萜烯三内酯GB烷基化，以产生包含萜内酯GA和烷基化萜三内酯GB的第一混合物; 或烷基化第三级分的萜烯三内酰胺GC，从而产生包括萜内酯GJ和烷基化萜三内酰胺GC的第二混合物，从而分离萜烯三内酯。

公开(公告)号：US20090156668A1

公开(公告)日：2009-06-18

申请号：US10593427

申请日：2005-03-21

申请人： Ottavio V. Vitolo ,  Koji Nakanishi ,  Michael L. Shelanski ,  Sonja Krane ,  Ottavio Arancio ,  Stanislav Jaracz ,  Nina D. Berova

发明人： Ottavio V. Vitolo ,  Koji Nakanishi ,  Michael L. Shelanski ,  Sonja Krane ,  Ottavio Arancio ,  Stanislav Jaracz ,  Nina D. Berova

IPC分类号： A61K31/365 ,  C07D493/22 ,  A61K51/00 ,  C12N5/02

CPC分类号： C07D493/18 ,  C07D493/22

摘要： The present invention relates to Ginkgolide derivatives, compositions and extracts comprising one or more Ginkgolides and/or derivatives thereof and methods of use of the compositions to treat neurological disorders and as imaging agents.

摘要翻译： 本发明涉及银杏内酯衍生物，包含一种或多种银杏内酯和/或其衍生物的组合物和提取物以及组合物用于治疗神经障碍和作为成像剂的方法。

公开(公告)号：US20050119336A1

公开(公告)日：2005-06-02

申请号：US10925209

申请日：2004-08-24

申请人： Koji Nakanishi ,  Stanislav Jaracz ,  Kristian Stromgaard

发明人： Koji Nakanishi ,  Stanislav Jaracz ,  Kristian Stromgaard

IPC分类号： A61K31/365 ,  C07D20060101 ,  C07D307/93 ,  C07D307/94 ,  C07D311/94 ,  C07D311/96 ,  C07D493/14

CPC分类号： C07D493/22

摘要： The subject invention provides ginkgolide C derivatives compounds having the structure: wherein R is H or -A-Ar, where A is an alkyl group; and Ar is an aryl group, which may contain heteroatoms and may be unsubstituted or substituted by one to five substituents each selected from the group consisting of hydrogen, alkoxy, —CH2CO2R4, and —CH2CONR5R6; where R4 is an alkyl group; and R5 and R6 are each, independently, hydrogen or a branched or unbranched alkyl group; wherein R1 is H or —COR7, where R7 is alkyl, aryl or amino; wherein R2 is present or absent, and when present is H, —COR8 or —CO-Z-R8; where R8 is alkyl, aryl or amino; and Z is oxygen; wherein R3 is present or absent, and when present is —COR9; where R9 is alkyl or aryl; wherein only one of R2 or R3 is present in the compound; wherein only two of R, R1, R2 and R3 are H; and wherein each of a and b designates a single covalent bond which is present or absent, where bond a is present when R3 is absent and bond b is present when R2 is absent; or an optically pure enantiomer of the compound. Additionally, the subject invention provides methods of inhibiting the activity of a glycine receptor using these compounds.

摘要翻译： 本发明提供具有以下结构的银杏内酯C衍生物化合物：其中R是H或-A-Ar，其中A是烷基; 并且Ar是可以含有杂原子的芳基，并且可以是未取代的或被一至五个选自氢，烷氧基，-CH 2 CO 2， R 4，R 4，R 4，R 6， 其中R 4是烷基; 和R 5和R 6各自独立地为氢或支链或非支链烷基; 其中R 1是H或-COR 7，其中R 7是烷基，芳基或氨基; 其中R 2存在或不存在，并且当存在时为H，-COR 8或-CO-Z-R 8; 其中R 8是烷基，芳基或氨基; Z为氧; 其中R 3存在或不存在，并且当存在时为-COR 9; 其中R 9是烷基或芳基; 其中R 2和R 3中只有一个存在于化合物中; 其中R 1，R 2，R 2和R 3中只有两个是H; 并且其中a和b中的每一个表示存在或不存在的单个共价键，其中当R 3不存在时存在键a，并且当R 2' 缺席; 或该化合物的光学纯对映异构体。 此外，本发明提供了使用这些化合物抑制甘氨酸受体的活性的方法。

公开(公告)号：US07429670B2

公开(公告)日：2008-09-30

申请号：US10925209

申请日：2004-08-24

申请人： Koji Nakanishi ,  Stanislav Jaracz ,  Kristian Stromgaard

发明人： Koji Nakanishi ,  Stanislav Jaracz ,  Kristian Stromgaard

IPC分类号： C07D305/14 ,  A01K43/12

CPC分类号： C07D493/22

摘要： The subject invention provides ginkgolide C derivatives compounds having the structure: wherein R is H or -A-Ar, where A is an alkyl group; and Ar is an aryl group, which may contain heteroatoms and may be unsubstituted or substituted by one to five substituents each selected from the group consisting of hydrogen, alkoxy, —CH2CO2R4, and —CH2CONR5R6; where R4 is an alkyl group; and R5 and R6 are each, independently, hydrogen or a branched or unbranched alkyl group; wherein R1 is H or —COR7, where R7 is alkyl, aryl or amino; wherein R2 is present or absent, and when present is H, —COR8 or —CO—Z—R8; where R8 is alkyl, aryl or amino; and Z is oxygen; wherein R3 is present or absent, and when present is —COR9; where R9 is alkyl or aryl; wherein only one of R2 or R3 is present in the compound; wherein only two of R, R1, R2 and R3 are H; and wherein each of a and b designates a single covalent bond which is present or absent, where bond a is present when R3 is absent and bond b is present when R2 is absent; or an optically pure enantiomer of the compound. Additionally, the subject invention provides methods of inhibiting the activity of a glycine receptor using these compounds.

摘要翻译： 本发明提供具有以下结构的银杏内酯C衍生物化合物：其中R是H或-A-Ar，其中A是烷基; 并且Ar是可以含有杂原子的芳基，并且可以是未取代的或被一至五个选自氢，烷氧基，-CH 2 CO 2， R 4，R 4，R 4，R 6， 其中R 4是烷基; 和R 5和R 6各自独立地为氢或支链或非支链烷基; 其中R 1是H或-COR 7，其中R 7是烷基，芳基或氨基; 其中R 2存在或不存在，并且当存在时为H，-COR 8或-CO-Z-R 8; 其中R 8是烷基，芳基或氨基; Z为氧; 其中R 3存在或不存在，并且当存在时为-COR 9; 其中R 9是烷基或芳基; 其中R 2和R 3中只有一个存在于化合物中; 其中R 1，R 2，R 2和R 3中只有两个是H; 并且其中a和b中的每一个表示存在或不存在的单个共价键，其中当R 3不存在时存在键a，并且当R 2' 缺席; 或该化合物的光学纯对映异构体。 此外，本发明提供了使用这些化合物抑制甘氨酸受体的活性的方法。

公开(公告)号：US20090221019A1

公开(公告)日：2009-09-03

申请号：US11922903

申请日：2006-06-22

申请人： Koji Nakanishi ,  Sergei Dzyuba ,  Hideki Ishii

发明人： Koji Nakanishi ,  Sergei Dzyuba ,  Hideki Ishii

IPC分类号： C12Q1/02 ,  C07D493/22

CPC分类号： C07D493/22

摘要： Lactone-rings of ginkgolides are converted into the corresponding tetrahydrofuran moieties via DIBAL-H reduction followed by deoxygenation of the formed lactols with Et3SiH/BF3Et2O producing a series of lactol-free ginkgolides. The present invention also relates to synthesis of hydroxyl-free, or hydroxyl-free and lactone-free, ginkgolides and bilobalides.

摘要翻译： 银杏内酯的内酯环通过DIBAL-H还原转化成相应的四氢呋喃部分，随后用Et 3 SiH / BF 3 Et 2 O脱氧所形成的乳糖，产生一系列无内酰胺的银杏内酯。 本发明还涉及无羟基或无羟基和不含内酯的银杏内酯和双甘草苷的合成。

公开(公告)号：US08067721B2

公开(公告)日：2011-11-29

申请号：US12508601

申请日：2009-07-24

申请人： Kenichiro Okura ,  Hidekazu Kodera ,  Koji Nakanishi

发明人： Kenichiro Okura ,  Hidekazu Kodera ,  Koji Nakanishi

IPC分类号： H01L27/00

CPC分类号： G03B21/28 ,  G03B21/10

摘要： A projection-type image display apparatus includes a first reflecting optical element and a second reflecting optical element that are retained on a base. A base-side first positioning unit and a base-side second positioning unit are formed integrally with the base. The base-side first positioning unit abuts against the first reflecting optical element to define a position of the first reflecting optical element. The base-side second positioning unit abuts against the second reflecting optical element to define a position of the second reflecting optical element.

摘要翻译： 投影型图像显示装置包括保持在基座上的第一反射光学元件和第二反射光学元件。 基座第一定位单元和基座侧第二定位单元与基座一体地形成。 底侧第一定位单元抵靠第一反射光学元件以限定第一反射光学元件的位置。 底侧第二定位单元抵靠第二反射光学元件以限定第二反射光学元件的位置。

公开(公告)号：US20110228233A1

公开(公告)日：2011-09-22

申请号：US13013901

申请日：2011-01-26

申请人： Shinji Yagyu ,  Koji Nakanishi

发明人： Shinji Yagyu ,  Koji Nakanishi

IPC分类号： G03B21/28 ,  G03B21/14

CPC分类号： G03B21/20 ,  G03B21/208 ,  G03B21/28 ,  H04N9/3152

摘要： A projection display device includes a light source, an optical intensity-equalizing element, an optical modulating element, an optical diffusion element, a relay optical system that is configured such that an output end of the optical intensity-equalizing element and a display element plane of the optical modulating element are optically conjugate, and a projection optical system. The relay optical system includes a first lens unit that condenses a light from the optical intensity-equalizing element and a second lens unit that further condenses a light from the first lens unit. The optical diffusion element is arranged between an light incident side of the first lens unit and the optical intensity-equalizing element. An optical axis of the second lens unit and a center of the output end of the optical intensity-equalizing element are shifted in a same direction from an optical axis of the first lens unit.

摘要翻译： 投影型显示装置具备：光源，光强均衡元件，光调制元件，光漫射元件，中继光学系统，其配置为使得光强均衡元件的输出端和显示元件面 光学调制元件是光学共轭的，以及投影光学系统。 中继光学系统包括：聚集来自光学强度均匀元件的光的第一透镜单元和进一步冷凝来自第一透镜单元的光的第二透镜单元。 光散射元件设置在第一透镜单元的光入射侧和光强度均衡元件之间。 第二透镜单元的光轴和光学强度均衡元件的输出端的中心从第一透镜单元的光轴沿同一方向偏移。

公开(公告)号：US20100275436A1

公开(公告)日：2010-11-04

申请号：US12811856

申请日：2009-01-15

申请人： Takaaki Kiyono ,  Hideaki Takahashi ,  Koji Nakanishi ,  Takeo Hayashida

发明人： Takaaki Kiyono ,  Hideaki Takahashi ,  Koji Nakanishi ,  Takeo Hayashida

IPC分类号： H02K15/00

CPC分类号： H02K15/12 ,  H02K15/022 ,  H02K15/066 ,  Y10T29/49009

摘要： Disclosed is a split stator manufacturing method, which is enabled to enhance a production efficiency and to charge a thermoplastic resin between an insulator and a coil by molding the resin. The split stator manufacturing method comprises a setting step of setting an insulator and a split stator core element in a stationary mold and setting an edgewise coil in a movable mold, a resin injecting step of injecting a resin into a cavity with the stationary mold and the movable mold being half-opened, and a clamping step of clamping the stationary mold and the movable mold.

摘要翻译： 公开了一种分体式定子制造方法，其能够通过模制树脂来提高生产效率并对绝缘体和线圈之间的热塑性树脂进行充电。 分体定子的制造方法包括将固定模具中的绝缘体和分割定子铁芯元件设定在可动模具中的设置步骤，将扁绕线圈设置在可动模具中，树脂注入步骤，用固定模具将树脂注入模腔， 可移动模具是半开的，夹紧步骤夹紧固定模具和活动模具。

公开(公告)号：US20100187918A1

公开(公告)日：2010-07-29

申请号：US12668531

申请日：2008-07-07

申请人： Hideaki Takahashi ,  Takaaki Kiyono ,  Koji Nakanishi

发明人： Hideaki Takahashi ,  Takaaki Kiyono ,  Koji Nakanishi

IPC分类号： H02K3/30 ,  H02K15/12

CPC分类号： H02K15/12 ,  H02K1/148 ,  H02K3/325 ,  H02K3/522 ,  H02K5/08 ,  H02K15/105 ,  Y10T29/49009

摘要： A split stator is arranged such that a formed edgewise coil is mounted on a teeth of a split stator core through an insulator, and a resin molded portion is formed excepting long ends of the edgewise coil.

摘要翻译： 分割定子被布置成使得通过绝缘体将形成的扁绕线圈安装在分割定子芯的齿上，并且形成除了扁绕线圈的长边之外的树脂模制部分。