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    Stabilized composition
    1.
    发明授权
    Stabilized composition 有权

    公开(公告)号：US09040564B2

    公开(公告)日：2015-05-26

    申请号：US11937393

    申请日：2007-11-08

    申请人： Koji Ukai ,  Norishige Takami

    发明人： Koji Ukai ,  Norishige Takami

    IPC分类号： A61K31/4439 ,  A61K31/4184 ,  A61K9/50

    CPC分类号： A61K31/4184 ,  A61K9/5047 ,  A61K9/5078 ,  A61K31/4439

    摘要： It is intended to provide a pharmaceutical composition which contains a proton pump inhibitor and is stable even if it is stored for a long time. It is also intended to provide a pharmaceutical composition which contains a proton pump inhibitor susceptible to acid, and does not dissolve in the stomach but dissolves in the intestine to release a primary drug product promptly. The object could be achieved by the pharmaceutical composition characterized in that a layer containing a proton pump inhibitor and ethyl cellulose, a layer containing an enteric polymer, and if necessary an intermediate layer composed of one or more layers are formed on a pharmacologically inactive core substance. The intermediate layer is composed of a water-insoluble polymer, a water-soluble polymer, a lubricant and the like.

    Stabilized composition
    2.
    发明申请
    Stabilized composition 审中-公开
    稳定组成

    公开(公告)号：US20090274756A1

    公开(公告)日：2009-11-05

    申请号：US11919229

    申请日：2006-04-17

    申请人： Koji Ukai ,  Norishige Takami

    发明人： Koji Ukai ,  Norishige Takami

    IPC分类号： A61K9/20 ,  A61K9/00 ,  A61K31/435 ,  A61K9/16 ,  A61P1/04

    CPC分类号： A61K9/5078 ,  A61K9/5047 ,  A61K31/4439

    摘要： It is intended to provide a pharmaceutical composition which contains a proton pump inhibitor and is stable even if it is stored for a long time. It is also intended to provide a pharmaceutical composition which contains a proton pump inhibitor susceptible to acid, and does not dissolve in the stomach but dissolves in the intestine to release a primary drug product promptly. The object could be achieved by the pharmaceutical composition characterized in that a layer containing a proton pump inhibitor and ethyl cellulose, a layer containing an enteric polymer, and if necessary an intermediate layer composed of one or more layers are formed on a pharmacologically inactive core substance. The intermediate layer is composed of a water-insoluble polymer, a water-soluble polymer, a lubricant and the like.

    摘要翻译： 旨在提供含有质子泵抑制剂的药物组合物，即使长时间储存​​也是稳定的。 还提供含有对酸敏感的质子泵抑制剂的药物组合物，并且不溶于胃，但溶解于肠中以迅速释放初级药物。 该目的可以通过药物组合物来实现，其特征在于，在药理学上不活泼的核心物质上形成含有质子泵抑制剂和乙基纤维素的层，含有肠溶性聚合物的层，如果必要的话，由一层或多层构成的中间层 。 中间层由水不溶性聚合物，水溶性聚合物，润滑剂等组成。

    STABILIZED COMPOSITION
    3.
    发明申请
    STABILIZED COMPOSITION 有权
    稳定组合物

    公开(公告)号：US20080145421A1

    公开(公告)日：2008-06-19

    申请号：US11937393

    申请日：2007-11-08

    申请人： Koji Ukai ,  Norishige Takami

    发明人： Koji Ukai ,  Norishige Takami

    IPC分类号： A61K9/48 ,  A61K31/4184 ,  A61K31/4439 ,  A61P1/04 ,  A61K9/14 ,  A61K9/30

    CPC分类号： A61K31/4184 ,  A61K9/5047 ,  A61K9/5078 ,  A61K31/4439

    摘要： It is intended to provide a pharmaceutical composition which contains a proton pump inhibitor and is stable even if it is stored for a long time. It is also intended to provide a pharmaceutical composition which contains a proton pump inhibitor susceptible to acid, and does not dissolve in the stomach but dissolves in the intestine to release a primary drug product promptly. The object could be achieved by the pharmaceutical composition characterized in that a layer containing a proton pump inhibitor and ethyl cellulose, a layer containing an enteric polymer, and if necessary an intermediate layer composed of one or more layers are formed on a pharmacologically inactive core substance. The intermediate layer is composed of a water-insoluble polymer, a water-soluble polymer, a lubricant and the like.

    摘要翻译： 旨在提供含有质子泵抑制剂的药物组合物，即使长时间储存​​也是稳定的。 还提供含有对酸敏感的质子泵抑制剂的药物组合物，并且不溶于胃，但溶解于肠中以迅速释放初级药物。 该目的可以通过药物组合物来实现，其特征在于，在药理学上不活泼的核心物质上形成含有质子泵抑制剂和乙基纤维素的层，含有肠溶性聚合物的层，如果必要的话，由一层或多层构成的中间层 。 中间层由水不溶性聚合物，水溶性聚合物，润滑剂等组成。

    Method of measuring coating quantity and method of predicting dissolution behavior
    4.
    发明授权
    Method of measuring coating quantity and method of predicting dissolution behavior 失效
    测量涂布量的方法和预测溶出行为的方法

    公开(公告)号：US08252362B2

    公开(公告)日：2012-08-28

    申请号：US11794763

    申请日：2006-02-02

    申请人： Makoto Yokoyama ,  Koji Ukai

    发明人： Makoto Yokoyama ,  Koji Ukai

    IPC分类号： C23C14/54

    CPC分类号： A61J3/005 ,  A61K9/282 ,  A61K9/2846 ,  A61K9/2866 ,  G01B11/0625 ,  G01N21/3563 ,  G01N21/359 ,  G01N33/15 ,  Y10T428/2991 ,  Y10T428/31504

    摘要： Evaluation methods that employ the near infrared spectrum have generally had a low specificity and in particular have encountered difficulty in the evaluation of trace components, and the accurate measurement of coating quantity by methods using the near infrared spectrum has been quite problematic. The quantity of coating applied to a coating target, such as granules or uncoated tablets, is measured based on the absorption or scattering of light in the 800 to 1100 nm wavelength region by an additive coated on the coating target. The use of polyethylene glycol or a long-chain hydrocarbyl-containing compound as the additive is preferred.

    摘要翻译： 使用近红外光谱的评价方法通常具有低的特异性，特别是在痕量成分的评价中遇到困难，通过使用近红外光谱的方法的涂布量的精确测量已经成问题。 基于通过涂覆在涂覆目标上的添加剂在800至1100nm波长区域中的光的吸收或散射来测量施加到涂覆靶材（例如颗粒或未包衣片剂）上的涂层的量。 优选使用聚乙二醇或长链烃基化合物作为添加剂。

    Pharmaceutical preparation to be dispersed before administration
    6.
    发明申请
    Pharmaceutical preparation to be dispersed before administration 审中-公开
    给药前待分散的药物制剂

    公开(公告)号：US20060165793A1

    公开(公告)日：2006-07-27

    申请号：US10564402

    申请日：2004-08-04

    申请人： Koji Ukai

    发明人： Koji Ukai

    IPC分类号： A61K31/717 ,  A61K9/26

    CPC分类号： A61K9/0095 ,  A61K9/5078 ,  A61K31/717 ,  A61K45/06

    摘要： The present invention provides a pharmaceutical preparation to be dispersed before administration which has an adequate viscosity and a suitable flowability even when dispersed in a small amount of water and can be easily administered through an NG tube is provided. Specifically, the pharmaceutical preparation to be dispersed before administration contains active granules containing a pharmaceutically active substance having an average particle diameter of 5 mm or less and a thickening agent, and can be administered through an NG tube by dispersing in water before administration.

    摘要翻译： 本发明提供了即使分散在少量的水中也可以容易地通过NG管施用的具有足够的粘度和合适的流动性的在给药前分散的药物制剂。 具体地说，给药前待分散的药物制剂含有含有平均粒径为5mm以下的药物活性物质和增稠剂的活性颗粒，并且可以通过NG管通过在给药前在水中分散来给药。

    Medicinal compositions with relieved bitterness
    7.
    发明授权
    Medicinal compositions with relieved bitterness 有权
    具有缓解苦味的药物组合物

    公开(公告)号：US06576677B1

    公开(公告)日：2003-06-10

    申请号：US09530391

    申请日：2000-04-28

    申请人： Koji Ukai ,  Tsutomu Harada

    发明人： Koji Ukai ,  Tsutomu Harada

    IPC分类号： A61K4732

    CPC分类号： A61K9/0095 ,  A61K47/32 ,  Y10S514/963

    摘要： The present invention provides a composition alleviated in a bitter taste or the like of a medicament. The present invention relates to a composition comprising a basic medicament having an unpleasant taste and polyvinylpyrrolidone and/or copolyvidone; or a method for alleviating an unpleasant taste of a basic medicament having the unpleasant taste by adding polyvinylpyrrolidone and/or copolyvidone. The present invention further provides a composition comprising (1) a basic medicament, (2) polyvinylpyrrolidone and/or copolyvidone, and (3) propylene glycol and/or D-sorbitol; a composition comprising (1) a basic medicament, (2) polyvinylpyrrolidone and/or copolyvidone, and (4) an antioxidant; and a composition comprising (1) a basic medicament, (2) polyvinylpyrrolidone and/or copolyvidone, and (5) a colorant or flavor containing a sulfuric acid or sulfurous acid group.

    摘要翻译： 本发明提供减轻药物的苦味等的组合物。 本发明涉及包含具有不愉快味道的碱性药物和聚乙烯吡咯烷酮和/或共聚维酮的组合物; 或通过加入聚乙烯吡咯烷酮和/或共聚维酮来减轻具有令人不快的味道的碱性药物令人不愉快的味道的方法。 本发明还提供一种组合物，其包含（1）碱性药物，（2）聚乙烯吡咯烷酮和/或共聚维酮，和（3）丙二醇和/或D-山梨糖醇; 一种组合物，其包含（1）碱性药物，（2）聚乙烯吡咯烷酮和/或共聚维酮，和（4）抗氧化剂; 和包含（1）碱性药物，（2）聚乙烯吡咯烷酮和/或共聚维酮的组合物，和（5）含有硫酸或亚硫酸基团的着色剂或香料。

    Method of measuring coating quantity and method of predicting dissolution behavior
    10.
    发明申请
    Method of measuring coating quantity and method of predicting dissolution behavior 失效
    测量涂布量的方法和预测溶出行为的方法

    公开(公告)号：US20090269484A1

    公开(公告)日：2009-10-29

    申请号：US11794763

    申请日：2006-02-02

    申请人： Makoto Yokoyama ,  Koji Ukai

    发明人： Makoto Yokoyama ,  Koji Ukai

    IPC分类号： B05D1/00

    CPC分类号： A61J3/005 ,  A61K9/282 ,  A61K9/2846 ,  A61K9/2866 ,  G01B11/0625 ,  G01N21/3563 ,  G01N21/359 ,  G01N33/15 ,  Y10T428/2991 ,  Y10T428/31504

    摘要： Evaluation methods that employ the near infrared spectrum have generally had a low specificity and in particular have encountered difficulty in the evaluation of trace components, and the accurate measurement of coating quantity by methods using the near infrared spectrum has been quite problematic. The quantity of coating applied to a coating target, such as granules or uncoated tablets, is measured based on the absorption or scattering of light in the 800 to 1100 nm wavelength region by an additive coated on the coating target. The use of polyethylene glycol or a long-chain hydrocarbyl-containing compound as the additive is preferred.

    摘要翻译： 使用近红外光谱的评价方法通常具有低的特异性，特别是在痕量成分的评价中遇到困难，通过使用近红外光谱的方法的涂布量的精确测量已经成问题。 基于通过涂覆在涂覆目标上的添加剂在800至1100nm波长区域中的光的吸收或散射来测量施加到涂覆靶材（例如颗粒或未包衣片剂）上的涂层的量。 优选使用聚乙二醇或长链烃基化合物作为添加剂。