公开(公告)号：US20180117218A1

公开(公告)日：2018-05-03

申请号：US15377372

申请日：2016-12-13

Applicant: Korea Institute of Science and Technology

Inventor： Dong Keun HAN ,  Yoon Ki JOUNG ,  Eugene LIH ,  Yun Ah KIM

IPC: A61L27/58 ,  A61L27/56 ,  A61L27/10 ,  A61L27/54 ,  A61L27/34 ,  A61L27/18 ,  A61L27/36 ,  A61L27/26 ,  C12N5/00

CPC classification number: A61L27/58 ,  A61K9/0024 ,  A61L27/10 ,  A61L27/18 ,  A61L27/26 ,  A61L27/34 ,  A61L27/3633 ,  A61L27/54 ,  A61L27/56 ,  A61L2300/252 ,  A61L2300/412 ,  A61L2300/414 ,  A61L2400/18 ,  C12N5/0068 ,  C12N2533/90

Abstract: Provided is an organic/inorganic hybrid-porous biodegradable polymer scaffold, which includes basic ceramic nanoparticles, an animal tissue or cell-derived bioactive first extracellular matrix material, and a biodegradable polymer and in which inner walls of pores are coated with a second extracellular matrix material.

公开(公告)号：US20170087280A1

公开(公告)日：2017-03-30

申请号：US15041239

申请日：2016-02-11

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Dongkeun HAN ,  Yoonki JOUNG ,  Jonghee KANG ,  Eugene LIH ,  Seongmin KIM

IPC: A61L31/16 ,  A61L31/10 ,  A61K31/137 ,  A61K31/436 ,  A61K33/08 ,  A61K31/616 ,  A61K31/4375 ,  A61K31/385 ,  C07K16/28 ,  A61K31/727 ,  A61K35/644 ,  A61K31/337 ,  A61K31/192 ,  A61K31/4365 ,  A61K31/196 ,  A61K31/519 ,  A61K33/06 ,  A61K31/565 ,  A61K38/07 ,  A61K33/00 ,  A61K31/343 ,  A61L31/14 ,  A61L31/02

CPC classification number: A61L31/16 ,  A61K31/137 ,  A61K31/192 ,  A61K31/196 ,  A61K31/337 ,  A61K31/343 ,  A61K31/365 ,  A61K31/385 ,  A61K31/436 ,  A61K31/4365 ,  A61K31/4375 ,  A61K31/519 ,  A61K31/565 ,  A61K31/616 ,  A61K31/727 ,  A61K33/00 ,  A61K33/06 ,  A61K33/08 ,  A61K33/14 ,  A61K33/16 ,  A61K35/644 ,  A61K38/07 ,  A61K39/3955 ,  A61K45/06 ,  A61L31/022 ,  A61L31/10 ,  A61L31/148 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2300/42 ,  A61L2420/08 ,  C07K16/2848 ,  C07K2317/24 ,  C07K2317/55 ,  A61K2300/00

Abstract: The present invention relates to a spatiotemporally multicontrollable intelligent drug-eluting adjustable stent, and a manufacturing method thereof, and includes a stent, a nano-coupling layer formed on the inner and outer surfaces of the stent and including a bioactive material into which a catechol group-containing adhesive derivative is introduced, and a second coating layer formed on the upper portion of the first coating layer and on the nano-coupling layer at the inner portion of the stent, and including an antithrombotic agent and an anti-inflammatory agent.