公开(公告)号：US09586936B2

公开(公告)日：2017-03-07

申请号：US14947204

申请日：2015-11-20

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Tae Bo Sim ,  Ho Jong Yoon ,  Ji Hye Yoon ,  Woo Young Hur ,  Eun Joo Roh ,  Yeon Ui Kwak

IPC: A61K31/506 ,  C07D403/04 ,  C07D401/14 ,  C07D471/04 ,  C07D487/04

CPC classification number: C07D403/04 ,  C07D401/14 ,  C07D471/04 ,  C07D487/04

Abstract: A heteroarylamine compound includes protein kinase inhibition activity, a pharmaceutically acceptable salt thereof and a pharmaceutical composition for preventing and treating a disease caused by abnormal cell growth, which contains the compound as an active ingredient.

Abstract translation: 杂芳基胺化合物包括蛋白激酶抑制活性，其药学上可接受的盐和用于预防和治疗由异常细胞生长引起的疾病的药物组合物，其含有该化合物作为活性成分。

公开(公告)号：US10683282B2

公开(公告)日：2020-06-16

申请号：US16362571

申请日：2019-03-22

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： So Ha Lee ,  Kyung Ho Yoo ,  Eun Joo Roh ,  Tae Bo Sim ,  Tae Young Kim ,  Jae Ho Kim

IPC: C07D405/14 ,  C07D405/12 ,  C07D403/12 ,  C07D401/12 ,  C07D239/48 ,  A61P35/00 ,  A61P25/28 ,  A61P37/02 ,  A61P29/00

Abstract: Disclosed are a novel pyrimidine derivative compound, a pharmaceutically acceptable salt thereof, a method for preparing the compound and a pharmaceutical use of the compound as an anticancer agent or a therapeutic agent for degenerative brain diseases. Specifically, the novel pyrimidine derivative compound has excellent inhibitory activities against kinase enzymes such as ARK5/NUAK1, ACK1, FLT3, JAK1, JAK2 and JAK2 (V617F) and thus is useful for treating and preventing leukemia, ovarian cancer, breast cancer, non-small cell carcinoma, colorectal cancer, glioma, and brain protein abnormalities such as Alzheimer's disease, progressive supranuclear palsy and frontotemporal dementia, that is, degenerative diseases caused by Tau deposition.

公开(公告)号：US10647685B2

公开(公告)日：2020-05-12

申请号：US16015596

申请日：2018-06-22

Applicant: Korea Institute of Science and Technology

Inventor： Eun Joo Roh ,  Karam Mohamed Hasan Fara Ahmed ,  So Ra Paik ,  Woo Young Hur ,  Elkamhawy Ahmed

IPC: C07D239/48 ,  A61P1/00 ,  A61P19/02 ,  C07D413/12

Abstract: The present invention relates to a 6-phenoxypyrimidine derivative, a method for preparing the compound and a pharmaceutical composition containing the compound as an active ingredient. Because the 6-phenoxypyrimidine compound represented by Chemical Formula 1 according to the present invention has an activity of inhibiting the production of nitric oxide (NO) as an inflammation-related factor, it is useful in treating and preventing inflammatory diseases including immunological diseases.

公开(公告)号：US10035795B1

公开(公告)日：2018-07-31

申请号：US15480839

申请日：2017-04-06

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Eun Joo Roh ,  Bo Ra Mi Jeon ,  Chang Joon Lee ,  Jin Pyo Hong ,  Joo Yeon Jeong ,  Sang Soo Kang

IPC: C07D417/06 ,  C07D279/28

CPC classification number: C07D417/06 ,  C07D279/28

Abstract: The present invention provides a phenothiazine derivative or a pharmaceutically acceptable salt thereof, a method of preparing a compound selected therefrom and a pharmaceutical composition containing the compound as an active ingredient. The phenothiazine derivative according to the present invention has an effect of inhibiting calmodulin (CaM; calcium-modulated protein) and thus helps cell death by maintaining the intracellular level of calcium in lung cancer cells at high concentration. Accordingly, the phenothiazine derivative according to the present invention can be usefully used to prevent or treat malignant tumors such as lung cancer.

公开(公告)号：US09834537B2

公开(公告)日：2017-12-05

申请号：US14092151

申请日：2013-11-27

Applicant: Korea Institute of Science and Technology

Inventor： Eun Joo Roh ,  Changjoon Justin Lee ,  Soo Jin Oh ,  Seok Jin Hwang ,  Jong Hoon Jung

IPC: C07C229/56 ,  C07D333/10 ,  C07D333/40 ,  C07C229/58

CPC classification number: C07D333/40 ,  C07C229/56 ,  C07C229/58

Abstract: Disclosed is a novel compound to function as a calcium-dependent chloride channel blocking agent.

公开(公告)号：US08871950B1

公开(公告)日：2014-10-28

申请号：US14065793

申请日：2013-10-29

Applicant: Korea Institute of Science and Technology

Inventor： Tae Bo Sim ,  Ho Jong Yoon ,  Eun Joo Roh

IPC: C07D203/10 ,  C07C229/08 ,  C07C227/02

CPC classification number: C07C227/02 ,  C07B2200/07 ,  C07C213/08 ,  C07C217/28 ,  C07C229/22 ,  C07D203/10

Abstract: The present invention relates to a method for preparing (+)-polyoxamic acid and a novel intermediate compound synthesized during preparation thereof.The preparation method according to the present invention allows preparation of (+)-polyoxamic acid with high optical purity in high yield. In particular, the preparation method is useful for mass production because the process is simple.

Abstract translation: 本发明涉及一种制备（+） - 聚氧杂恶唑酸的方法及其制备过程中合成的新型中间体化合物。 根据本发明的制备方法允许以高产率制备具有高光学纯度的（+） - 多异羟肟酸。 特别是，由于该方法简单，所以制备方法对于批量生产是有用的。