公开(公告)号：US10155767B2

公开(公告)日：2018-12-18

申请号：US15672987

申请日：2017-08-09

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Tae Bo Sim ,  Han Na Cho ,  Eun Hye Ju ,  Woo Young Hur ,  Ho Jong Yoon ,  Chi Man Song

IPC: C07D487/04

Abstract: The present invention provides a therapeutic agent of acute myeloid leukemia containing a 1,3,7-trisubstituted 3,4-dihydropyrimido[4,5-d]pyrimidine-2(1H)-one compound as an active ingredient, which has proliferation inhibitory activity for a human acute myeloid leukemia cell line OCI-AML3 having a NRAS mutant gene while having low inhibitory activity for wild type NRAS and has activity of inhibiting GCK and ACK1 protein kinases at the same time.

公开(公告)号：US10647685B2

公开(公告)日：2020-05-12

申请号：US16015596

申请日：2018-06-22

Applicant: Korea Institute of Science and Technology

Inventor： Eun Joo Roh ,  Karam Mohamed Hasan Fara Ahmed ,  So Ra Paik ,  Woo Young Hur ,  Elkamhawy Ahmed

IPC: C07D239/48 ,  A61P1/00 ,  A61P19/02 ,  C07D413/12

Abstract: The present invention relates to a 6-phenoxypyrimidine derivative, a method for preparing the compound and a pharmaceutical composition containing the compound as an active ingredient. Because the 6-phenoxypyrimidine compound represented by Chemical Formula 1 according to the present invention has an activity of inhibiting the production of nitric oxide (NO) as an inflammation-related factor, it is useful in treating and preventing inflammatory diseases including immunological diseases.

公开(公告)号：US20190047993A1

公开(公告)日：2019-02-14

申请号：US15998791

申请日：2018-08-16

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  DAEGU-GYEONGBUK MEDICAL INNOVATION FOUNDATION

Inventor： Tae Bo Sim ,  Woo Young Hur ,  Chi Man Song ,  Ho Jong Yoon ,  Seung Hye Choi ,  Han Na Cho ,  Hwan Geun Choi ,  Nam Doo Kim ,  Jung Beom Son ,  Eun Hwa Ko ,  Hyun Kyoung Kim ,  Joong Heui Cho ,  Seock Yong Kang ,  So Young Kim ,  Yi Kyung Ko ,  Seung Yeon Lee ,  Suk Kyoon Yoon ,  Jae Hyun Bae

IPC: C07D409/12 ,  A61P35/02 ,  C07D409/14

CPC classification number: C07D409/12 ,  A61K31/381 ,  A61K31/4436 ,  A61P35/02 ,  C07D333/10 ,  C07D409/14 ,  Y02P20/55

Abstract: The present invention relates to a novel 2,3,5-substituted thiophene compound having inhibitory activity against kinases, an anticancer agent including the compound as an active ingredient, and a method for preparing the compound.

公开(公告)号：US10059717B2

公开(公告)日：2018-08-28

申请号：US15674023

申请日：2017-08-10

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Tae Bo Sim ,  Woo Young Hur ,  Ho Jong Yoon ,  Chi Man Song ,  Eun Hye Ju ,  Han na Cho ,  Hwan Geun Choi

IPC: C07D487/04 ,  C07D403/14 ,  C07D401/14 ,  A61K31/4985 ,  A61P35/00 ,  A61P35/02

CPC classification number: C07D487/04 ,  C07D401/14 ,  C07D403/14

Abstract: The present invention provides a pharmaceutical composition, as an effective ingredient, a urea compound having a protein kinase inhibitory activity and containing a 3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one skeleton, and a pharmaceutically acceptable salt thereof.

公开(公告)号：US10442796B2

公开(公告)日：2019-10-15

申请号：US15998791

申请日：2018-08-16

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  DAEGU-GYEONGBUK MEDICAL INNOVATION FOUNDATION

Inventor： Tae Bo Sim ,  Woo Young Hur ,  Chi Man Song ,  Ho Jong Yoon ,  Seung Hye Choi ,  Han Na Cho ,  Hwan Geun Choi ,  Nam Doo Kim ,  Jung Beom Son ,  Eun Hwa Ko ,  Hyun Kyoung Kim ,  Joong Heui Cho ,  Seock Yong Kang ,  So Young Kim ,  Yi Kyung Ko ,  Seung Yeon Lee ,  Suk Kyoon Yoon ,  Jae Hyun Bae

IPC: C07D409/12 ,  A61P35/02 ,  A61K31/381 ,  A61K31/4436 ,  C07D333/10 ,  C07D409/14

Abstract: The present invention relates to a novel 2,3,5-substituted thiophene compound having inhibitory activity against kinases, an anticancer agent including the compound as an active ingredient, and a method for preparing the compound.

公开(公告)号：US10130631B2

公开(公告)日：2018-11-20

申请号：US15677742

申请日：2017-08-15

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Tae Bo Sim ,  Ho Jong Yoon ,  Woo Young Hur ,  Yun Ju Nam ,  Hwan Geun Choi

IPC: A61K31/506 ,  A61K31/519 ,  A61K31/5377

Abstract: The present invention relates to a therapeutic agent for chronic myelogenous leukemia with reduced drug-resistance and side-effects containing a 1,6-disubstituted indole compound.

公开(公告)号：US09586936B2

公开(公告)日：2017-03-07

申请号：US14947204

申请日：2015-11-20

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Tae Bo Sim ,  Ho Jong Yoon ,  Ji Hye Yoon ,  Woo Young Hur ,  Eun Joo Roh ,  Yeon Ui Kwak

IPC: A61K31/506 ,  C07D403/04 ,  C07D401/14 ,  C07D471/04 ,  C07D487/04

CPC classification number: C07D403/04 ,  C07D401/14 ,  C07D471/04 ,  C07D487/04

Abstract: A heteroarylamine compound includes protein kinase inhibition activity, a pharmaceutically acceptable salt thereof and a pharmaceutical composition for preventing and treating a disease caused by abnormal cell growth, which contains the compound as an active ingredient.

Abstract translation: 杂芳基胺化合物包括蛋白激酶抑制活性，其药学上可接受的盐和用于预防和治疗由异常细胞生长引起的疾病的药物组合物，其含有该化合物作为活性成分。