公开(公告)号：US20170266235A1

公开(公告)日：2017-09-21

申请号：US15506216

申请日：2015-08-13

Applicant: Korea Research Institute of Bioscience and Biotechnology

Inventor： Sang Chul Lee ,  Baek Soo Han ,  Kwang-Hee Bae ,  Hyejin Kim ,  Won Kon Kim ,  Kyoung Jin Oh

IPC: A61K35/30 ,  C12N5/0793 ,  C12N5/10 ,  A61K38/17 ,  C12N5/074

CPC classification number: A61K35/30 ,  A61K38/1787 ,  A61K45/00 ,  A61K48/00 ,  C12N5/00 ,  C12N5/0607 ,  C12N5/0619 ,  C12N5/10 ,  C12N2502/08

Abstract: The present invention relates to a method for producing cholinergic neurons comprising obtaining neural progenitor cells from stem cells so as to continuously produce cholinergic neural cells with high purity and the same traits, followed by differentiating the neural progenitor cells into the cholinergic neurons, and cholinergic neurons produced therefrom. Since the method of preparing the cholinergic neurons provided in the present invention enables not only production of the cholinergic neurons with high purity, but also rapid production of the cholinergic neurons with the same traits, it can be widely used for effectively treating degenerative cranial nerve diseases such as Alzheimer's disease.

公开(公告)号：US10231999B2

公开(公告)日：2019-03-19

申请号：US15506216

申请日：2015-08-13

Applicant: Korea Research Institute of Bioscience and Biotechnology

Inventor： Sang Chul Lee ,  Baek Soo Han ,  Kwang-Hee Bae ,  Hyejin Kim ,  Won Kon Kim ,  Kyoung Jin Oh

IPC: A61K35/30 ,  C12N5/0793 ,  C12N5/10 ,  A61K38/17 ,  C12N5/074 ,  A61K45/00 ,  A61K48/00 ,  C12N5/00

Abstract: The present invention relates to a method for producing cholinergic neurons comprising obtaining neural progenitor cells from stem cells so as to continuously produce cholinergic neural cells with high purity and the same traits, followed by differentiating the neural progenitor cells into the cholinergic neurons, and cholinergic neurons produced therefrom. Since the method of preparing the cholinergic neurons provided in the present invention enables not only production of the cholinergic neurons with high purity, but also rapid production of the cholinergic neurons with the same traits, it can be widely used for effectively treating degenerative cranial nerve diseases such as Alzheimer's disease.