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公开(公告)号：US10231999B2
公开(公告)日：2019-03-19
申请号：US15506216
申请日：2015-08-13
Inventor： Sang Chul Lee , Baek Soo Han , Kwang-Hee Bae , Hyejin Kim , Won Kon Kim , Kyoung Jin Oh
Abstract: The present invention relates to a method for producing cholinergic neurons comprising obtaining neural progenitor cells from stem cells so as to continuously produce cholinergic neural cells with high purity and the same traits, followed by differentiating the neural progenitor cells into the cholinergic neurons, and cholinergic neurons produced therefrom. Since the method of preparing the cholinergic neurons provided in the present invention enables not only production of the cholinergic neurons with high purity, but also rapid production of the cholinergic neurons with the same traits, it can be widely used for effectively treating degenerative cranial nerve diseases such as Alzheimer's disease.
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公开(公告)号：US10760051B2
公开(公告)日：2020-09-01
申请号：US15506626
申请日：2015-08-13
Inventor： Baek Soo Han , Sang Chul Lee , Kwang-Hee Bae , Cheonok Lee , Won Kon Kim , Kyoung Jin Oh
IPC: C12N5/079
Abstract: The present invention relates to a method for producing astrocytes comprising obtaining neural progenitor cells from stem cells so as to continuously produce astrocytes with high purity and same traits, followed by two steps of differentiating the neural progenitor cells into the astrocytes, and astrocytes produced therefrom. Since the method of preparing the astrocytes provided in the present invention enables not only production of the astrocytes with high purity and faster production of the astrocytes with same characteristics, but also rapid differentiation of the astrocytes using the neural progenitor cells when necessary, it can be widely used for effectively treating a patient with a disease which requires transplantation of the astrocytes.
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公开(公告)号：US20170267971A1
公开(公告)日：2017-09-21
申请号：US15506626
申请日：2015-08-13
Inventor： Baek Soo Han , Sang Chul Lee , Kwang-Hee Bae , Cheonok Lee , Won Kon Kim , Kyoung Jin Oh
IPC: C12N5/079
Abstract: The present invention relates to a method for producing astrocytes comprising obtaining neural progenitor cells from stem cells so as to continuously produce astrocytes with high purity and same traits, followed by two steps of differentiating the neural progenitor cells into the astrocytes, and astrocytes produced therefrom. Since the method of preparing the astrocytes provided in the present invention enables not only production of the astrocytes with high purity and faster production of the astrocytes with same characteristics, but also rapid differentiation of the astrocytes using the neural progenitor cells when necessary, it can be widely used for effectively treating a patient with a disease which requires transplantation of the astrocytes.
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公开(公告)号：US20170266235A1
公开(公告)日：2017-09-21
申请号：US15506216
申请日：2015-08-13
Inventor： Sang Chul Lee , Baek Soo Han , Kwang-Hee Bae , Hyejin Kim , Won Kon Kim , Kyoung Jin Oh
IPC: A61K35/30 , C12N5/0793 , C12N5/10 , A61K38/17 , C12N5/074
CPC classification number: A61K35/30 , A61K38/1787 , A61K45/00 , A61K48/00 , C12N5/00 , C12N5/0607 , C12N5/0619 , C12N5/10 , C12N2502/08
Abstract: The present invention relates to a method for producing cholinergic neurons comprising obtaining neural progenitor cells from stem cells so as to continuously produce cholinergic neural cells with high purity and the same traits, followed by differentiating the neural progenitor cells into the cholinergic neurons, and cholinergic neurons produced therefrom. Since the method of preparing the cholinergic neurons provided in the present invention enables not only production of the cholinergic neurons with high purity, but also rapid production of the cholinergic neurons with the same traits, it can be widely used for effectively treating degenerative cranial nerve diseases such as Alzheimer's disease.
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