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公开(公告)号：US09763908B2
公开(公告)日：2017-09-19
申请号：US14915799
申请日：2014-09-03
发明人： Jae Wha Kim , Sei-Ryang Oh , Kyung Seop Ahn , Ho Bum Kang , Jae Mine Yoo , Tae-Suk Lee , JongKoo Kang , Hye Kyung Kim , Jin Soo Yook , Yong-Hae Han , Ki Young Sohn
CPC分类号： A61K31/231 , A23L33/10 , A23V2002/00 , A61K8/37 , A61K9/0014 , A61K9/08 , A61K47/44 , A61K2800/10 , A61Q19/00
摘要： The present invention relates to a pharmaceutical composition, functional health food composition, quasi-drug composition, and cosmetic composition containing a monoacetyldiacylglycerol compound as an active ingredient for preventing, treating or improving atopic dermatitis. The monoacetyldiacylglycerol compound of the present invention has an excellent effect of suppression of IL-4 and IgE secretion, thereby overcoming side effects of an atopic dermatitis treatment agent currently in use, having no toxicity, and exhibiting an excellent treatment effect, and thus can be useful as a composition for preventing, treating, and ameliorating atopic dermatitis.
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公开(公告)号：US20210052536A1
公开(公告)日：2021-02-25
申请号：US17010806
申请日：2020-09-02
发明人： Sei-Ryang Oh , Ok-Kyoung Kwon , Chan Mi Chun , Su Ui Lee , Kyung Seop Ahn , In Sik Shin , Seung Hyung Kim , Hye Kyung Kim , JongKoo Kang , Yong-Hae Han , Tae-Suk Lee , Ki Young Sohn
IPC分类号： A61K31/231
摘要： The present invention relates to a pharmaceutical composition containing a monoacetyldiacylglycerol compound as an active ingredient for preventing or treating chronic obstructive pulmonary diseases, and a functional health food composition for treating or preventing chronic obstructive pulmonary diseases. The monoacetyldiacylglycerol compound of the present invention inhibits the IL-4 expression in EL-4 cells and inhibits the infiltration of inflammatory cells into the bronchial tube in an animal model. In addition, the compounds of the present invention have an excellent effect of inhibiting the expression of CXCL-1, TNF-α, or MIP-2, thereby overcoming side effects of the currently used therapeutic agents for chronic obstructive pulmonary diseases, having no toxicity, and exhibiting a superior therapeutic effect, and thus can be useful as a composition for preventing, treating, and alleviating chronic obstructive pulmonary diseases.
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公开(公告)号：US11192864B2
公开(公告)日：2021-12-07
申请号：US16962287
申请日：2019-01-11
发明人： Jae Yong Lee , Jong Soo Lee , Byung Kyu Kang , Byuong Woo Lee , Sang Oh Lee , Dae Myoung Yun , Jae Hun Bang , Ki Young Sohn
IPC分类号： C07D257/02 , A61K49/10
摘要： Disclosed is a method for producing calcobutrol used as an MRI contrast agent. The method comprises the steps of: obtaining butrol represented by chemical formula 2 in the specification by reacting a gadobutrol represented by chemical formula 1 in the specification and a decomplexing agent; and obtaining a calcobutrol represented by chemical Formula 3 in the specification by reacting butrol with calcium ions.
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公开(公告)号：US10653657B2
公开(公告)日：2020-05-19
申请号：US15775811
申请日：2016-11-14
发明人： Ki Young Sohn , Jae Wha Kim
IPC分类号： A61K31/231 , A61P7/06 , A61P7/00 , A61P13/12 , A61K9/48 , A61K31/739 , A61K31/138 , A61K31/675 , A61K31/7068 , A61K31/15
摘要： The present invention provides methods for treating, controlling or mitigating hemolytic uremic syndrome (HUS), comprising administering a monoacetyldiacylglycerol compound to a patient in need thereof, as well as compositions useful therefor.
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公开(公告)号：US11135193B2
公开(公告)日：2021-10-05
申请号：US16127930
申请日：2018-09-11
发明人： Sei-Ryang Oh , Kyung Seop Ahn , Su Ui Lee , In Sik Shin , Na-Rae Shin , Tae-Suk Lee , JongKoo Kang , Young-Sik Jung , Yong-Hae Han , Ki Young Sohn
IPC分类号： A61K31/231 , A61K35/32 , A23L33/00 , A23K20/00
摘要： The present invention relates to a pharmaceutical composition containing a monoacetyldiacyiglycerol compound as an active ingredient for preventing or treating asthma, and a functional health food composition for preventing or treating asthma. The monoacetyldiacylglycerol compound of the present invention inhibits the expression of IL-4 in EL-4 cells, which are mouse T cell lymphoma cells, reduces hypersensitivity of airway in an asthma-induced animal model, and inhibits the infiltration of inflammatory cells into the bronchial tube. In addition, the compounds of the present invention inhibit the generation of IgE in the serum and bronchoalveolar lavage fluid, have an excellent effect of inhibiting the expression of Th2 cytokines (IL-4, IL-5, and IL-13) in the lung, thereby overcome side effects of the currently used therapeutic agents for asthma, have no toxicity, and exhibit a superior therapeutic effect, and thus can be useful as a composition for preventing, treating, and alleviating asthma.
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6.发明申请公开(公告)号：US20200330421A1
公开(公告)日：2020-10-22
申请号：US16886280
申请日：2020-05-28
发明人： Jae Wha Kim , Sei-Ryang Oh , Kyung Seop Ahn , Ho Bum Kang , Jae Min Shin , Young Eun Ko , Tae Suk Lee , Myung Hwan Kim , Jong Koo Kang , Yong-Hae Han , Ki Young Sohn
IPC分类号： A61K31/231 , A23L33/10 , A61K35/32 , A61K31/23
摘要： The present invention relates to a composition containing a monoacetyldiglyceride compound as an active ingredient, for inhibiting blood cancer or metastasis, and a use thereof. The monoacetyldiglyceride compound according to the present invention has excellent effects of inhibiting the expression of IL-4 and inhibiting the activity of STAT-6, and thereby is capable of overcoming side effects of currently used blood cancer or metastasis inhibiting agents. Also, the monoacetyldiglyceride compound is a non-toxic compound having superior therapeutic effects and thus can be useful as a composition for preventing, treating, or improving blood cancer and metastasis.
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公开(公告)号：US10098864B2
公开(公告)日：2018-10-16
申请号：US14912920
申请日：2014-08-19
发明人： Sei-Ryang Oh , Kyung Seop Ahn , Su Ui Lee , In Sik Shin , Na-Rae Shin , Tae-Suk Lee , JongKoo Kang , Young-Sik Jung , Yong-Hae Han , Ki Young Sohn
IPC分类号： A61K31/231 , A61K35/32 , A23L33/00 , A23K20/00
摘要： The present invention relates to a pharmaceutical composition containing a monoacetyldiacylglycerol compound as an active ingredient for preventing or treating asthma, and a functional health food composition for preventing or treating asthma. The monoacetyldiacylglycerol compound of the present invention inhibits the expression of IL-4 in EL-4 cells, which are mouse T cell lymphoma cells, reduces hypersensitivity of airway in an asthma-induced animal model, and inhibits the infiltration of inflammatory cells into the bronchial tube. In addition, the compounds of the present invention inhibit the generation of IgE in the serum and bronchoalveolar lavage fluid, have an excellent effect of inhibiting the expression of Th2 cytokines (IL-4, IL-5, and IL-13) in the lung, thereby overcome side effects of the currently used therapeutic agents for asthma, have no toxicity, and exhibit a superior therapeutic effect, and thus can be useful as a composition for preventing, treating, and alleviating asthma.
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8.发明申请公开(公告)号：US20210100767A1
公开(公告)日：2021-04-08
申请号：US17114473
申请日：2020-12-07
发明人： Ki Young Sohn , Sun Young Yoon
IPC分类号： A61K31/231 , A61P43/00 , A61K45/06 , A61K38/19
摘要： In one aspect, use of 1-palmitoyl-2-linoleoyl-3-acetylglycerol (PLAG) for treating or preventing acute radiation syndrome is provided.
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公开(公告)号：US10765655B2
公开(公告)日：2020-09-08
申请号：US15857933
申请日：2017-12-29
发明人： Sei-Ryang Oh , Kyung Seop Ahn , Su Ui Lee , In Sik Shin , Ok-Kyoung Kwon , Seung Hyung Kim , Chan Mi Chun , Tae-Suk Lee , Yong-Hae Han , Ki Young Sohn , JongKoo Kang , Hye Kyung Kim
IPC分类号： A61K31/231
摘要： The present invention relates to a pharmaceutical composition containing a monoacetyldiacylglycerol compound as an active ingredient for preventing or treating chronic obstructive pulmonary diseases, and a functional health food composition for treating or preventing chronic obstructive pulmonary diseases. The monoacetyldiacylglycerol compound of the present invention inhibits the IL-4 expression in EL-4 cells and inhibits the infiltration of inflammatory cells into the bronchial tube in an animal model. In addition, the compounds of the present invention have an excellent effect of inhibiting the expression of CXCL-1, TNF-α, or MIP-2, thereby overcoming side effects of the currently used therapeutic agents for chronic obstructive pulmonary diseases, having no toxicity, and exhibiting a superior therapeutic effect, and thus can be useful as a composition for preventing, treating, and alleviating chronic obstructive pulmonary diseases.
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10.发明授权公开(公告)号：US12076307B2
公开(公告)日：2024-09-03
申请号：US16888716
申请日：2020-05-30
发明人： Ki Young Sohn , Sun Young Yoon
IPC分类号： A61K31/231 , A61K38/19 , A61K45/06 , A61P39/00 , A61P43/00
CPC分类号： A61K31/231 , A61K38/193 , A61K45/06 , A61P39/00 , A61P43/00
摘要： In one aspect, use of 1-palmitoyl-2-linoleoyl-3-acetylglycerol (PLAG) for treating or preventing acute radiation syndrome is provided.
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