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公开(公告)号：US10053443B2
公开(公告)日：2018-08-21
申请号：US15449465
申请日：2017-03-03
申请人： KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY , DONGGUK UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
发明人： Kyeong Lee , Sei-Ryang Oh , Kyung Seop Ahn , Ok-Kyoung Kwon , Doo-Young Kim , Hyung Won Ryu , Jung Hee Kim , Xuezhen Xu
IPC分类号： A61K31/343 , C07D307/86 , A23L33/10
CPC分类号： C07D307/86 , A23L33/10 , A23V2002/00 , A61K31/05 , A61K31/343 , C07D307/78 , C07D307/79 , C07D307/80 , C07D307/81
摘要： The present invention relates to a novel 2-phenylbenzofuran derivative or a pharmaceutically acceptable salt thereof, a production method for the same, and a pharmaceutical composition for preventing or treating an inflammatory disease comprising the same as an active ingredient, and the novel 2-phenylbenzofuran derivative or the pharmaceutically acceptable salt thereof according to the present invention is outstandingly effective in suppressing NO, IL-6, and TNF-alpha induced by macrophages, and therefore can advantageously be used in a pharmaceutical composition for preventing or treating an inflammatory disease.
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公开(公告)号：US10376553B2
公开(公告)日：2019-08-13
申请号：US15573207
申请日：2016-05-13
发明人： Sei-Ryang Oh , Kyung Seop Ahn , Su Ui Lee , Hyung Won Ryu , Doo-Young Kim , Hyeong Kyu Lee , Ok-Kyoung Kwon , Jung Hee Kim , Hyun-Jun Lee , In-Sik Shin
IPC分类号： A61K36/575 , A61P11/00 , A61K31/34 , A61K31/36 , A61P9/00 , A61P35/00 , A61K31/357 , A61K9/00 , A61K47/38
摘要： A pharmaceutical composition includes any of an extract of Magnoliae flos, a fraction or an active fraction obtained by fractionation thereof with an organic solvent, and a compound separated therefrom as an active ingredient. The extract of Magnoliae flos, the fraction or the active fraction obtained by fractionation thereof with an organic solvent, or the compound separated therefrom inhibits the expression of MUC5AC induced by TNF-α and the promoter activity in human lung cancer mucosal cells (H292), reduces the number of inflammatory cells in the bronchoalveolar lavage fluid of the chronic obstructive pulmonary disease mouse model, inhibits the production of reactive oxygen species, and reduces the cytokines; and therefore are effective in preventing or treating chronic obstructive pulmonary disease.
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公开(公告)号：US20210052536A1
公开(公告)日：2021-02-25
申请号：US17010806
申请日：2020-09-02
发明人： Sei-Ryang Oh , Ok-Kyoung Kwon , Chan Mi Chun , Su Ui Lee , Kyung Seop Ahn , In Sik Shin , Seung Hyung Kim , Hye Kyung Kim , JongKoo Kang , Yong-Hae Han , Tae-Suk Lee , Ki Young Sohn
IPC分类号： A61K31/231
摘要： The present invention relates to a pharmaceutical composition containing a monoacetyldiacylglycerol compound as an active ingredient for preventing or treating chronic obstructive pulmonary diseases, and a functional health food composition for treating or preventing chronic obstructive pulmonary diseases. The monoacetyldiacylglycerol compound of the present invention inhibits the IL-4 expression in EL-4 cells and inhibits the infiltration of inflammatory cells into the bronchial tube in an animal model. In addition, the compounds of the present invention have an excellent effect of inhibiting the expression of CXCL-1, TNF-α, or MIP-2, thereby overcoming side effects of the currently used therapeutic agents for chronic obstructive pulmonary diseases, having no toxicity, and exhibiting a superior therapeutic effect, and thus can be useful as a composition for preventing, treating, and alleviating chronic obstructive pulmonary diseases.
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公开(公告)号：US10172816B2
公开(公告)日：2019-01-08
申请号：US15384302
申请日：2016-12-19
发明人： Yongnam Lee , Ji-seok Yoo , Dae-hee Shin , Byung-hwan Ryoo , Kyung Seop Ahn , Sei Ryang Oh , Hyeong Kyu Lee , In Sik Shin , Doo Young Kim , Ok-Kyoung Kwon , Hyuk Hwan Song , Seung Hyung Kim , SuUi Lee
IPC分类号： A61K31/192 , A61K31/7048 , A61K36/80 , A61K31/194 , A23L33/105
摘要： A composition comprising a purified extract isolated from Pseudolysimachion rotundum var. subintegrum containing abundant amount of active ingredient or the compounds isolated therefrom as an active ingredient for treating a chronic obstructive pulmonary disease and the use thereof. Inventive purified extract and compounds showed potent anti-COPD activity without beta-2-receptor agonistic response through various in vivo tests as well as in vitro test. Therefore, it can be used as the therapeutics or functional health food for treating and preventing chronic obstructive pulmonary disease (COPD).
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公开(公告)号：US09655871B2
公开(公告)日：2017-05-23
申请号：US14780503
申请日：2014-04-09
发明人： Yongnam Lee , Ji-seok Yoo , Dae-hee Shin , Byung-hwan Ryoo , Kyung Seop Ahn , Sei Ryang Oh , Hyeong Kyu Lee , In Sik Shin , Doo Young Kim , Ok-Kyoung Kwon , Hyuk Hwan Song , Seung Hyung Kim , SuUi Lee
IPC分类号： A61K31/192 , A61K31/7048 , A61K36/80 , A61K31/194 , A23L33/105
CPC分类号： A61K31/192 , A23L33/105 , A61K31/194 , A61K31/7048 , A61K36/80 , A61K2236/00
摘要： A composition comprising a purified extract isolated from Pseudolysimachion rotundum var. subintegrum containing abundant amount of active ingredient or the compounds isolated therefrom as an active ingredient for treating a chronic obstructive pulmonary disease and the use thereof. Inventive purified extract and compounds showed potent anti-COPD activity without beta-2-receptor agonistic response through various in vivo tests as well as in vitro test. Therefore, it can be used as the therapeutics or functional health food for treating and preventing chronic obstructive pulmonary disease (COPD).
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6.发明授权Pharmaceutical composition for treating wounds or revitalizing skin comprising Euphorbia kansui extracts, fractions thereof or diterpene compounds separated from the fractions as active ingredient 有权用于治疗伤口或活化皮肤的药物组合物，其包含从所述级分分离的大戟属提取物，其级分或二萜化合物作为活性成分公开(公告)号：US09061022B2
公开(公告)日：2015-06-23
申请号：US14559254
申请日：2014-12-03
发明人： Jae Wha Kim , Sei Ryang Oh , Kyung Seop Ahn , Ho Bum Kang , Ok-Kyoung Kwon , Seung Ho Kim , Jang Mi Son , Hyuk Hwan Song , Hee Gu Lee , Byeong Hwa Jeon , Da Jung Ji , Khiev Piseth
IPC分类号： A01N65/00 , A61K36/47 , A61K31/215 , A61K36/00
CPC分类号： A61K36/47 , A23L33/105 , A23V2002/00 , A61K8/97 , A61K31/215 , A61K31/23 , A61K31/231 , A61K36/00 , A61Q19/00 , A61Q19/08 , A23V2200/318 , A23V2250/21
摘要： The present invention relates to a pharmaceutical composition for treating wounds or revitalizing skin comprising the Euphorbia kansui extract, the fractions thereof, or the diterpene compound isolated therefrom as an active ingredient. The Euphorbia kansui extract may act on epithelial cells to induce PKD1 activity required for improving the reproduction capability of differentiated epithelial cells, and thus may induce the phosphorylation of lower ERK1 and the generation of Cycline D, thus exhibiting an excellent ability to activate the reproduction of damaged skin. Therefore, the Euphorbia kansui extract may be used effectively as an active ingredient in a pharmaceutical composition for treating wounds or reproducing skin, a health food for recovering skin damage or reproducing skin, or a functional cosmetic for inducing skin cell activity.
摘要翻译： 本发明涉及一种用于治疗伤口或活化皮肤的药物组合物，其包含从其分离的大戟油提取物，其级分或作为活性成分的二萜化合物。 大戟甘油提取物可以作用于上皮细胞以诱导提高分化的上皮细胞繁殖能力所需的PKD1活性，从而可能诱导较低ERK1的磷酸化和产生Cycline D，从而表现出极好的激活繁殖能力的能力 皮肤受损 因此，大戟科提取物可以有效地用作用于治疗伤口或再生皮肤的药物组合物中的活性成分，用于恢复皮肤损伤或再现皮肤的保健食品或用于诱导皮肤细胞活性的功能性化妆品。
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