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    Method for screening peptides for use in immunotherapy
    1.
    发明授权
    Method for screening peptides for use in immunotherapy 有权
    筛选用于免疫治疗的肽的方法

    公开(公告)号：US07425606B2

    公开(公告)日：2008-09-16

    申请号：US10333430

    申请日：2001-07-20

    申请人： Kostas Kosmatopoulos ,  Sophie Tourdot ,  Antonio Scardino ,  Alexandre David Gross

    发明人： Kostas Kosmatopoulos ,  Sophie Tourdot ,  Antonio Scardino ,  Alexandre David Gross

    IPC分类号： C07K2/00

    CPC分类号： C07K14/005 ,  C07K14/71 ,  C12N9/1241 ,  C12N2740/16222 ,  G01N33/56977

    摘要： Identifying subdominant/cryptic epitopes (I) that are presented by a HLA (human leukocyte antigen) Class I molecule, is new. Identifying subdominant/cryptic epitopes (I) that are presented by a HLA (human leukocyte antigen) Class I molecule comprising selecting at least one peptide (II) of 8-11 amino acids (aa), potentially representing an epitope for Class I presentation, from a protein against which a cytotoxic T cell (CTL) response is to be raised. (II) corresponds to a non-immunogenic peptide with low affinity for Class I molecules. Variants (IIa) of (II) are prepared in which the N-terminal aa is replaced by Tyr and their immunogenicity detected by identifying those that generate a CTL response against target cells expressing the parent protein. Peptide sequences from which active (IIa) are derived are then identified. Independent claims are also included for the following: (1) immunogenic peptide epitopes (IIa) derived from (I) identified this way; and (2) nucleic acid (III) that encodes chimeric polypeptides (IV) containing one or more, same or different, copies of (IIa).

    摘要翻译： 鉴定由HLA（人白细胞抗原）I类分子呈递的亚显性/隐性表位（I）是新的。 鉴定由HLA（人白细胞抗原）I类分子呈递的亚显性/隐性表位（I），包括选择至少一种8-11个氨基酸（aa）的肽（II），潜在地代表I型呈递的表位， 来自提高细胞毒性T细胞（CTL）应答的蛋白质。 （II）对应于对I类分子具有低亲和力的非免疫原性肽。 制备（II）的变体（IIa），其中N末端aa被Tyr取代，并且通过鉴定对表达亲本蛋白的靶细胞产生CTL应答的那些检测其免疫原性。 然后鉴定衍生活性（IIa）的肽序列。 还包括以下独立权利要求：（1）以这种方式鉴定的衍生自（I）的免疫原性肽表位（IIa） 和（2）编码含有一个或多个，相同或不同的（IIa）拷贝的嵌合多肽（IV）的核酸（III）。

    Method for screening peptides for use in immunotherapy
    2.
    发明授权
    Method for screening peptides for use in immunotherapy 有权
    筛选用于免疫治疗的肽的方法

    公开(公告)号：US07976843B2

    公开(公告)日：2011-07-12

    申请号：US12186856

    申请日：2008-08-06

    申请人： Kostas Kosmatopoulos ,  Sophie Tourdot ,  Antonio Scardino ,  David Alexandre Gross

    发明人： Kostas Kosmatopoulos ,  Sophie Tourdot ,  Antonio Scardino ,  David Alexandre Gross

    IPC分类号： A61K39/00 ,  C07K2/00

    CPC分类号： C07K14/005 ,  C07K14/71 ,  C12N9/1241 ,  C12N2740/16222 ,  G01N33/56977

    摘要： Identifying subdominant/cryptic epitopes (I) that are presented by a HLA (human leukocyte antigen) Class I molecule, is new. Identifying subdominant/cryptic epitopes (I) that are presented by a HLA (human leukocyte antigen) Class I molecule comprising selecting at least one peptide (II) of 8-11 amino acids (aa), potentially representing an epitope for Class I presentation, from a protein against which a cytotoxic T cell (CTL) response is to be raised. (II) corresponds to a non-immunogenic peptide with low affinity for Class I molecules. Variants (IIa) of (II) are prepared in which the N-terminal aa is replaced by Tyr and their immunogenicity detected by identifying those that generate a CTL response against target cells expressing the parent protein. Peptide sequences from which active (IIa) are derived are then identified. Independent claims are also included for the following: (1) immunogenic peptide epitopes (IIa) derived from (I) identified this way; and (2) nucleic acid (III) that encodes chimeric polypeptides (IV) containing one or more, same or different, copies of (IIa).

    摘要翻译： 鉴定由HLA（人白细胞抗原）I类分子呈递的亚显性/隐性表位（I）是新的。 鉴定由HLA（人白细胞抗原）I类分子呈递的亚显性/隐性表位（I），包括选择至少一种8-11个氨基酸（aa）的肽（II），潜在地代表I型呈递的表位， 来自提高细胞毒性T细胞（CTL）应答的蛋白质。 （II）对应于对I类分子具有低亲和力的非免疫原性肽。 制备（II）的变体（IIa），其中N末端aa被Tyr取代，并且通过鉴定对表达亲本蛋白的靶细胞产生CTL应答的那些检测其免疫原性。 然后鉴定衍生活性（IIa）的肽序列。 还包括以下独立权利要求：（1）以这种方式鉴定的衍生自（I）的免疫原性肽表位（IIa） 和（2）编码含有一个或多个，相同或不同的（IIa）拷贝的嵌合多肽（IV）的核酸（III）。

    METHOD FOR SCREENING PEPTIDES FOR USE IN IMMUNOTHERAPY
    3.
    发明申请
    METHOD FOR SCREENING PEPTIDES FOR USE IN IMMUNOTHERAPY 有权
    筛选用于免疫缺陷病毒的方法

    公开(公告)号：US20090269363A1

    公开(公告)日：2009-10-29

    申请号：US12186856

    申请日：2008-08-06

    申请人： Kostas Kosmatopoulos ,  Sophie Tourdot ,  Antonio Scardino ,  David Alexandre Gross

    发明人： Kostas Kosmatopoulos ,  Sophie Tourdot ,  Antonio Scardino ,  David Alexandre Gross

    IPC分类号： A61K39/00 ,  G01N33/567 ,  A61K38/00 ,  C07H21/02 ,  A61K31/7088 ,  A61P37/04

    CPC分类号： C07K14/005 ,  C07K14/71 ,  C12N9/1241 ,  C12N2740/16222 ,  G01N33/56977

    摘要： Identifying subdominant/cryptic epitopes (I) that are presented by a HLA (human leukocyte antigen) Class I molecule, is new. Identifying subdominant/cryptic epitopes (I) that are presented by a HLA (human leukocyte antigen) Class I molecule comprising selecting at least one peptide (II) of 8-11 amino acids (aa), potentially representing an epitope for Class I presentation, from a protein against which a cytotoxic T cell (CTL) response is to be raised. (II) corresponds to a non-immunogenic peptide with low affinity for Class I molecules. Variants (IIa) of (II) are prepared in which the N-terminal aa is replaced by Tyr and their immunogenicity detected by identifying those that generate a CTL response against target cells expressing the parent protein. Peptide sequences from which active (IIa) are derived are then identified. Independent claims are also included for the following: (1) immunogenic peptide epitopes (IIa) derived from (I) identified this way; and (2) nucleic acid (III) that encodes chimeric polypeptides (IV) containing one or more, same or different, copies of (IIa).

    摘要翻译： 鉴定由HLA（人白细胞抗原）I类分子呈递的亚显性/隐性表位（I）是新的。 鉴定由HLA（人白细胞抗原）I类分子呈递的亚显性/隐性表位（I），包括选择至少一种8-11个氨基酸（aa）的肽（II），潜在地代表I型呈递的表位， 来自提高细胞毒性T细胞（CTL）应答的蛋白质。 （II）对应于对I类分子具有低亲和力的非免疫原性肽。 制备（II）的变体（IIa），其中N末端aa被Tyr取代，并且通过鉴定对表达亲本蛋白的靶细胞产生CTL应答的那些检测其免疫原性。 然后鉴定衍生活性（IIa）的肽序列。 还包括以下独立权利要求：（1）以这种方式鉴定的衍生自（I）的免疫原性肽表位（IIa） 和（2）编码含有一个或多个，相同或不同的（IIa）拷贝的嵌合多肽（IV）的核酸（III）。

    Peptide epitopes common to antigens of the same multigene family
    4.
    发明授权
    Peptide epitopes common to antigens of the same multigene family 有权
    同一多基因家族抗原共同的肽表位

    公开(公告)号：US07419669B2

    公开(公告)日：2008-09-02

    申请号：US10508548

    申请日：2003-03-27

    申请人： Kostas Kosmatopoulos ,  Stephanie Graff-Dubois

    发明人： Kostas Kosmatopoulos ,  Stephanie Graff-Dubois

    IPC分类号： A61K39/00

    CPC分类号： C07K14/4748 ,  C07K14/71 ,  G01N33/57492 ,  G01N33/6878

    摘要： The invention relates to the production of peptide epitopes common to a plurality of antigens of the same multigene family, said epitopes containing at least one common pentapeptide sequence preceded by three amino acids at the N-terminal end and optionally followed by one or two amino acids at the C-terminal end. The invention also relates to polynucleotides coding for said epitopes. Said peptides and polynucleotides can be especially used in anti-tumour immunotherapy.

    摘要翻译： 本发明涉及对同一多基因家族的多种抗原共有的肽表位的生产，所述表位含有至少一个常见的五肽序列，其前三个氨基酸位于N-末端，并且任选地含有一个或两个氨基酸 在C末端。 本发明还涉及编码所述表位的多核苷酸。 所述肽和多核苷酸可以特别用于抗肿瘤免疫治疗。

    Peptide epitopes common to antigens of the same multigene family
    7.
    发明申请
    Peptide epitopes common to antigens of the same multigene family 有权
    同一多基因家族抗原共同的肽表位

    公开(公告)号：US20060263381A1

    公开(公告)日：2006-11-23

    申请号：US10508548

    申请日：2003-03-27

    申请人： Kostas Kosmatopoulos ,  Stephanie Graff-Dubois

    发明人： Kostas Kosmatopoulos ,  Stephanie Graff-Dubois

    IPC分类号： A61K48/00 ,  C07K14/82 ,  C07K14/74 ,  A61K39/00 ,  C07H21/04

    CPC分类号： C07K14/4748 ,  C07K14/71 ,  G01N33/57492 ,  G01N33/6878

    摘要： The invention relates to the production of peptide epitopes common to a plurality of antigens of the same multigene family, said epitopes containing at least one common pentapeptide sequence preceded by three amino acids at the N-terminal end and optionally followed by one or two amino acids at the C-terminal end. The invention also relates to polynucleotides coding for said epitopes. Said peptides and polynucleotides can be especially used in anti-tumour immunotherapy.

    摘要翻译： 本发明涉及对同一多基因家族的多种抗原共有的肽表位的生产，所述表位含有至少一个常见的五肽序列，其前三个氨基酸位于N-末端，并且任选地含有一个或两个氨基酸 在C末端。 本发明还涉及编码所述表位的多核苷酸。 所述肽和多核苷酸可以特别用于抗肿瘤免疫治疗。