公开(公告)号：US07417060B2

公开(公告)日：2008-08-26

申请号：US11016886

申请日：2004-12-21

申请人： Kouji Hattori ,  Susumu Toda ,  Masashi Imanishi ,  Shinji Ito ,  Kenichi Washizuka ,  Takanobu Araki ,  Minoru Sakurai ,  Daisuke Tanabe

发明人： Kouji Hattori ,  Susumu Toda ,  Masashi Imanishi ,  Shinji Ito ,  Kenichi Washizuka ,  Takanobu Araki ,  Minoru Sakurai ,  Daisuke Tanabe

IPC分类号： A61K31/44 ,  A61K31/195

CPC分类号： C07C229/56 ,  C07C229/38 ,  C07C271/16 ,  C07C311/51 ,  C07C323/63 ,  Y02P20/55

摘要： The present invention relates to a compound formula[I]: wherein X is bond, —CH2—, —O— or —NH—, R1 and R12 are each independently hydrogen, halogen, lower alkyl, etc., R2 is hydrogen or optionally substituted lower alkyl, R3 is hydrogen or an amino protective group, R4, R5 and R6 are each independently hydrogen or optionally substituted lower alkyl, R7 is -Z-R13, in which Z is bond, etc., and R13 is carboxy, lower alkoxycarbonyl, (lower alkylsulfonyl)carbamoyl or lower alkanoylsulfamoyl, R8 is —Y—R9, in which Y is bond, —CH2—, —O—, —S—, etc., and R9 is hydrogen, lower alkyl, cyclo(lower)alkyl, etc., and R11 is hydrogen, lower alkyl, lower alkoxy, etc., or a salt thereof. The compound [I] of the present invention and pharmaceutically acceptable salts thereof are useful for the prophylactic and/or the therapeutic treatment of pollakiurea or urinary incontinence.

摘要翻译： 本发明涉及化合物式[I]：其中X是键，-CH 2 - ， - O-或-NH-，R 1和R 2 > 12个各自独立地为氢，卤素，低级烷基等，R 2为氢或任选取代的低级烷基，R 3为氢或氨基 保护基，R 4，R 5和R 6各自独立地为氢或任选取代的低级烷基，R 7 O 其中Z为键，等等，R 13为羧基，低级烷氧基羰基，（低级烷基磺酰基）氨基甲酰基或低级烷酰基氨磺酰基，R 0为 其中Y为键，-CH 2 - ， - O - ， - S-等，其中R为 - 低级烷基，环（低级）烷基等，R 11是氢，低级烷基，低级烷氧基等，或其盐。 本发明的化合物[I]及其药学上可接受的盐可用于预防和/或治疗呼吸窘迫症或尿失禁。

公开(公告)号：US20050137236A1

公开(公告)日：2005-06-23

申请号：US11016886

申请日：2004-12-21

申请人： Kouji Hattori ,  Susumu Toda ,  Masashi Imanishi ,  Shinji Ito ,  Kenichi Washizuka ,  Takanobu Araki ,  Minoru Sakurai ,  Daisuke Tanabe

发明人： Kouji Hattori ,  Susumu Toda ,  Masashi Imanishi ,  Shinji Ito ,  Kenichi Washizuka ,  Takanobu Araki ,  Minoru Sakurai ,  Daisuke Tanabe

IPC分类号： C07C229/38 ,  C07C229/56 ,  C07C271/16 ,  C07C311/51 ,  C07C323/63 ,  C07D213/38 ,  C07D213/61 ,  A61K31/44 ,  A61K31/195

CPC分类号： C07C229/56 ,  C07C229/38 ,  C07C271/16 ,  C07C311/51 ,  C07C323/63 ,  Y02P20/55

摘要： The present invention relates to a compound formula[I]: wherein X is bond, —CH2—, —O— or —NH—, R1 and R12 are each independently hydrogen, halogen, lower alkyl, etc., R2 is hydrogen or optionally substituted lower alkyl, R3 is hydrogen or an amino protective group, R4, R5 and R6 are each independently hydrogen or optionally substituted lower alkyl, R7 is -Z-R13, in which Z is bond, etc., and R13 is carboxy, lower alkoxycarbonyl, (lower alkylsulfonyl)carbamoyl or lower alkanoylsulfamoyl, R8 is —Y—R9, in which Y is bond, —CH2—, —O—, —S—, etc., and R9 is hydrogen, lower alkyl, cyclo(lower)alkyl, etc., and R11 is hydrogen, lower alkyl, lower alkoxy, etc., or a salt thereof. The compound [I] of the present invention and pharmaceutically acceptable salts thereof are useful for the prophylactic and/or the therapeutic treatment of pollakiurea or urinary incontinence.

摘要翻译： 本发明涉及化合物式[I]：其中X是键，-CH 2 - ， - O-或-NH-，R 1和R 2 > 12个各自独立地为氢，卤素，低级烷基等，R 2为氢或任选取代的低级烷基，R 3为氢或氨基 保护基，R 4，R 5和R 6各自独立地为氢或任选取代的低级烷基，R 7 O 其中Z为键，等等，R 13为羧基，低级烷氧基羰基，（低级烷基磺酰基）氨基甲酰基或低级烷酰基氨磺酰基，R 0为 其中Y为键，-CH 2 - ， - O - ， - S-等，其中R为 - 低级烷基，环（低级）烷基等，R 11是氢，低级烷基，低级烷氧基等，或其盐。 本发明的化合物[I]及其药学上可接受的盐可用于预防和/或治疗呼吸窘迫症或尿失禁。

公开(公告)号：US07928264B2

公开(公告)日：2011-04-19

申请号：US11547847

申请日：2005-09-20

申请人： Kouji Hattori ,  Susumu Toda ,  Kenichi Washizuka ,  Shinji Ito ,  Daisuke Tanabe ,  Takanobu Araki ,  Minoru Sakurai

发明人： Kouji Hattori ,  Susumu Toda ,  Kenichi Washizuka ,  Shinji Ito ,  Daisuke Tanabe ,  Takanobu Araki ,  Minoru Sakurai

IPC分类号： C07C213/00

CPC分类号： C07D213/70 ,  C07C311/51 ,  C07C323/63 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2602/10 ,  C07D209/42 ,  C07D213/38 ,  Y02P20/55

摘要： The present invention relates to a compound of the formula [I]: wherein (a), in which —Y—, R4, R5 and R6 are4 R5 each as defined in the description, etc., R1 is hydrogen, halogen, lower alkyl, hydroxy, etc., R2 is hydrogen, lower alkyl or hydroxy(lower)alkyl, R3 is hydrogen or an amino protective group, 20R7 is hydrogen, lower alkyl, cyclo(lower)alkyl, lower R9 alkenyl, —Z—R9 or (b), in which —Z— is —0—, —S—, R9 —SO— or —SO2—, and each R9 is independently hydrogen, lower alkyl, cyclo(lower)alkyl, etc., and R8 is -D-E-R10, in which -D- is —CONHSO2— or —S02NHCO—, E is bond or lower alkylene, and R10 is halogen, cyano, carboxy, etc., or a prodrug thereof or a salt thereof. The compound [I] of the present invention and pharmaceutically acceptable salts thereof are useful for the prophylactic and/or the therapeutic treatment of ulcer, overactive bladder, and the like.

摘要翻译： 本发明涉及式[I]的化合物：其中（a）其中-Y-，R4，R5和R6各自如说明书中所定义的R 5等，R 1是氢，卤素，低级烷基 ，羟基等，R2是氢，低级烷基或羟基（低级）烷基，R3是氢或氨基保护基，20R7是氢，低级烷基，环（低级）烷基，低级R9链烯基，-Z-R9或 （b）中，-Z-是-O - ， - S - ，R 9 -SO-或-SO 2 - ，各R 9独立地是氢，低级烷基，环（低级）烷基等， DE-R10，其中-D-是-CONHSO2-或-SO 2 NHCO-，E是键或低级亚烷基，R 10是卤素，氰基，羧基等，或其前药或其盐。 本发明的化合物[I]及其药学上可接受的盐可用于溃疡，膀胱过度活动症等的预防和/或治疗性治疗。

公开(公告)号：US20080039506A1

公开(公告)日：2008-02-14

申请号：US11547847

申请日：2005-09-20

申请人： Kouji Hattori ,  Susumu Toda ,  Kenichi Washizuka ,  Shinji Ito ,  Daisuke Tanabe ,  Takanobu Araki ,  Minoru Sakurai

发明人： Kouji Hattori ,  Susumu Toda ,  Kenichi Washizuka ,  Shinji Ito ,  Daisuke Tanabe ,  Takanobu Araki ,  Minoru Sakurai

IPC分类号： A61K31/44 ,  A61K31/164 ,  A61K31/265 ,  A61P1/04 ,  C07C233/00 ,  C07D213/02 ,  C07C271/00 ,  A61P13/10 ,  A61K31/35 ,  A61K31/404

CPC分类号： C07D213/70 ,  C07C311/51 ,  C07C323/63 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2602/10 ,  C07D209/42 ,  C07D213/38 ,  Y02P20/55

摘要： The present invention relates to a compound of the formula [I]: wherein (a), in which —Y—, R4, R5 and R6 are4 R5 each as defined in the description, etc., R1 is hydrogen, halogen, lower alkyl, hydroxy, etc., R2 is hydrogen, lower alkyl or hydroxy(lower)alkyl, R3 is hydrogen or an amino protective group, 20R7 is hydrogen, lower alkyl, cyclo(lower)alkyl, lower R9 alkenyl, -Z-R9 or (b), in which -Z- is -0-, —S—, R9—SO— or —SO2—, and each R9 is independently hydrogen, lower alkyl, cyclo(lower)alkyl, etc., and R8 is -D-E-R , in which -D- is —CONHSO2— or —S02NHCO—, E is bond or lower alkylene, and R10 is halogen, cyano, carboxy, etc., or a prodrug thereof or a salt thereof. The compound [I] of the present invention and pharmaceutically acceptable salts thereof are useful for the prophylactic and/or the therapeutic treatment of ulcer, overactive bladder, and the like.

摘要翻译： 本发明涉及式[I]化合物：其中（a），其中-Y-，R 4，R 5和R 6 每一个如说明书中所定义的，其中R 1是氢，卤素，低级烷基，羟基 等等，R 2是氢，低级烷基或羟基（低级）烷基，R 3是氢或氨基保护基，R 20，R 20， 其中-Z-是-O - ， - S - ， - S（O） - ， - （R） 9个-SO-或-SO 2 - ，每个R 9独立地是氢，低级烷基，环（低级）烷基等，R 其中D是-CONHSO 2 - 或-SO 2 NHCO-，其中D是 - E是键或低级亚烷基，R 10是卤素，氰基，羧基等，或其前药或其盐。 本发明的化合物[I]及其药学上可接受的盐可用于溃疡，膀胱过度活动症等的预防和/或治疗性治疗。

公开(公告)号：US09822867B2

公开(公告)日：2017-11-21

申请号：US12570519

申请日：2009-09-30

申请人： Shinji Ito ,  Masufumi Kugai

发明人： Shinji Ito ,  Masufumi Kugai

IPC分类号： F16H57/02 ,  F16H57/027

CPC分类号： F16H57/027 ,  Y10T74/2188

摘要： A motorcycle wherein only air can be communicated between the inside and the outside of a gear case without increasing the size of the gear case. A gear case includes a gear case body and a gear case cover. The gear case body includes a breather chamber of a labyrinth structure which continues in a circumferential direction of a rear wheel and extends in an upward and downward direction. An upper end of the breather chamber is in communication with a breather path and is open to atmospheric air while a lower end of the breather chamber is in communication with a gear chamber through a slit extending in a widthwise direction of the rear wheel.

公开(公告)号：US09068308B2

公开(公告)日：2015-06-30

申请号：US13883307

申请日：2010-12-09

申请人： Shinji Ito ,  Tatsuo Masuda ,  Yasuji Hashimoto

发明人： Shinji Ito ,  Tatsuo Masuda ,  Yasuji Hashimoto

IPC分类号： A01B43/00 ,  E01H12/00

CPC分类号： E01H12/002

摘要： A beach cleaner for recovering relatively heavy garbage or stones while minimizing the amount of sand entering a garbage recovery unit. The beach cleaner includes a frame formed by a longitudinal member and a lateral member. A towed portion is provided at the front portion of the frame for towing by a tow vehicle. A separator is provided at the lower front portion of the frame to separate and scrape garbage from sandy ground. A recovery unit is provided behind the separator to collect garbage scraped onto the mesh member. At least one separation rod unit is provided having a plurality of longitudinal members and a lateral member for joining the rear ends of the respective longitudinal members. The front end of at least one separation rod unit is secured to the separator so as to be turnable in the up-and-down direction.

摘要翻译： 用于恢复相对较重的垃圾或石头的沙滩清洁剂，同时尽量减少进入垃圾回收装置的沙量。 海滩清洁器包括由纵向构件和横向构件形成的框架。 牵引部分设置在框架的前部，用拖车牵引。 在框架的下前部设有一个分离器，以分离和刮擦沙地的垃圾。 在分离器后面设置一个回收单元，以收集刮到网状构件上的垃圾。 提供至少一个分离杆单元，其具有多个纵向构件和用于连接各个纵向构件的后端的侧向构件。 至少一个分离杆单元的前端固定到分离器上，以便能够在上下方向上转动。

公开(公告)号：US20140030349A1

公开(公告)日：2014-01-30

申请号：US14112424

申请日：2012-04-18

申请人： Shinji Ito ,  Seika Ooiwa

发明人： Shinji Ito ,  Seika Ooiwa

IPC分类号： A61K9/50 ,  A61K47/36 ,  A61K36/22

CPC分类号： A61K9/5042 ,  A61K9/06 ,  A61K9/5036 ,  A61K9/5047 ,  A61K36/22 ,  A61K47/36

摘要： A formulation which comprises coated granules and a water-soluble gel, wherein the coated granules comprise an oil absorbent which comprises cashew nut shell liquid, anacardic acid, cardanol, or cardol, and wherein the coated granules are suspended in the water-soluble gel.

摘要翻译： 一种包含包衣颗粒和水溶性凝胶的制剂，其中所述包衣颗粒包含含有腰果壳液，漆树酸，腰果酚或卡诺酚的吸油剂，其中所述包衣颗粒悬浮在水溶性凝胶中。

公开(公告)号：US08634441B2

公开(公告)日：2014-01-21

申请号：US13421016

申请日：2012-03-15

申请人： Takashi Onose ,  Shinji Ito

发明人： Takashi Onose ,  Shinji Ito

IPC分类号： H01S3/10

CPC分类号： H01S3/0085 ,  H01S3/094061 ,  H01S3/2316 ,  H01S3/2325 ,  H01S3/235 ,  H01S3/2375

摘要： A master oscillator may include: a pumping laser that outputs pumping light; a seed laser that is oscillated by the pumping light; an amplifier that amplifies the pulsed laser light outputted by the seed laser using the pumping light; at least one optical shutter disposed in the optical path between the seed laser and the amplifier; and a controller that causes the pumping laser to oscillate continuously at a predetermined repetition rate and that controls the optical shutter to open and close.

摘要翻译： 主振荡器可以包括：输出泵浦光的泵浦激光器; 通过泵浦光振荡的种子激光器; 放大器，其使用所述泵浦光放大由所述种子激光器输出的脉冲激光; 设置在种子激光器和放大器之间的光路中的至少一个光学快门; 以及使泵浦激光以预定的重复频率连续振荡并且控制光学快门打开和关闭的控制器。

公开(公告)号：US20130233579A1

公开(公告)日：2013-09-12

申请号：US13883307

申请日：2010-12-09

申请人： Shinji Ito ,  Tatsuo Masuda ,  Yasuji Hashimoto

发明人： Shinji Ito ,  Tatsuo Masuda ,  Yasuji Hashimoto

IPC分类号： E01H12/00

CPC分类号： E01H12/002

摘要： A beach cleaner for recovering relatively heavy garbage or stones while minimizing the amount of sand entering a garbage recovery unit. The beach cleaner includes a frame formed by a longitudinal member and a lateral member. A towed portion is provided at the front portion of the frame for towing by a tow vehicle. A separator is provided at the lower front portion of the frame to separate and scrape garbage from sandy ground. A recovery unit is provided behind the separator to collect garbage scraped onto the mesh member. At least one separation rod unit is provided having a plurality of longitudinal members and a lateral member for joining the rear ends of the respective longitudinal members. The front end of at least one separation rod unit is secured to the separator so as to be turnable in the up-and-down direction.

摘要翻译： 用于恢复相对较重的垃圾或石头的沙滩清洁剂，同时尽量减少进入垃圾回收装置的沙量。 海滩清洁器包括由纵向构件和横向构件形成的框架。 牵引部分设置在框架的前部，用拖车牵引。 在框架的下前部设有一个分离器，以分离和刮擦沙地的垃圾。 在分离器后面设置一个回收单元，以收集刮到网状构件上的垃圾。 提供至少一个分离杆单元，其具有多个纵向构件和用于连接各个纵向构件的后端的侧向构件。 至少一个分离杆单元的前端固定到分离器上，以便能够在上下方向上转动。

公开(公告)号：US20130220896A1

公开(公告)日：2013-08-29

申请号：US13884745

申请日：2010-12-22

申请人： Shinji Ito ,  Tatsuo Masuda ,  Yasuji Hashimoto

发明人： Shinji Ito ,  Tatsuo Masuda ,  Yasuji Hashimoto

IPC分类号： E01H12/00

CPC分类号： E01H12/00

摘要： There is provided a work vehicle having a wheel lock mechanism that is compactly disposed while avoiding an effect of surrounding sand. A wheel lock mechanism 201 has a disc portion 202 rotating integrally with a wheel 53 inside a rim portion 56A of the wheel 53, and a slide member 20X that is movable in the axial direction of the wheel 52 so as to be freely engageable with the disc portion 202 inside the rim portion 56A and rotates integrally with the axle 52.

摘要翻译： 提供了一种具有紧凑设置的轮锁机构的作业车辆，同时避免了周围砂的影响。 车轮锁定机构201具有与车轮53的轮辋部56A内的车轮53一体旋转的盘部202，以及能够沿车轮52的轴向移动以能够与车轮53的轴线方向自由接合的滑动构件20X 边缘部分56A内的圆盘部分202和轴52一体地旋转。