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1.发明授权Method of treating inflammation with antibodies to neutrophil chemotactic factor 失效用嗜中性粒细胞趋化因子抗体治疗炎症的方法
公开(公告)号：US5925352A
公开(公告)日：1999-07-20
申请号：US935560
申请日：1997-09-23
申请人： Kouji Matsushima , Teizo Yoshimura , Edward J. Leonard , Joost Oppenheim , Ettore Appella , Stephen D. Showalter
发明人： Kouji Matsushima , Teizo Yoshimura , Edward J. Leonard , Joost Oppenheim , Ettore Appella , Stephen D. Showalter
IPC分类号： G01N33/53 , A61K38/00 , A61K39/395 , A61P29/00 , C07K14/52 , C07K14/54 , C07K16/00 , C07K16/24 , C12N5/10 , C12N15/09 , C12N15/12 , C12N15/19 , C12P21/08 , C12Q1/68 , C12R1/91 , G01N33/577
CPC分类号： C07K14/5421 , C07K16/244 , A61K38/00 , Y10S435/81 , Y10S514/885 , Y10S930/12
摘要： An isloated, synthetic preparation of a novel neutrophil-specific chemotactic factor (NCF), monoclonal antibodies having specific binding affinity for NCF and a clone containing the complete cDNA coding sequence for NCF are disclosed.
摘要翻译： 公开了一种新型嗜中性粒细胞特异性趋化因子（NCF）的合成制剂，对NCF具有特异性结合亲和力的单克隆抗体和含有NCF完整cDNA编码序列的克隆。
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公开(公告)号：US5698196A
公开(公告)日：1997-12-16
申请号：US467612
申请日：1995-06-06
申请人： Kouji Matsushima , Teizo Yoshimura , Edward J. Leonard , Joost Oppenheim , Ettore Appella , Stephen D. Showalter
发明人： Kouji Matsushima , Teizo Yoshimura , Edward J. Leonard , Joost Oppenheim , Ettore Appella , Stephen D. Showalter
IPC分类号： G01N33/53 , A61K38/00 , A61K39/395 , A61P29/00 , C07K14/52 , C07K14/54 , C07K16/00 , C07K16/24 , C12N5/10 , C12N15/09 , C12N15/12 , C12N15/19 , C12P21/08 , C12Q1/68 , C12R1/91 , G01N33/577 , C12N5/16
CPC分类号： C07K14/5421 , C07K16/244 , A61K38/00 , Y10S435/81 , Y10S514/885 , Y10S930/12
摘要： The present invention relates to an isolated, synthetic preparation of a novel neutrophil-specific chemotactic factor (NCF), monoclonal antibodies having specific binding affinity for NCF and a clone containing the complete coding sequence for NCF.
摘要翻译： 本发明涉及一种新型嗜中性粒细胞特异性趋化因子（NCF）的分离合成制剂，对NCF具有特异性结合亲和力的单克隆抗体和含有NCF完整编码序列的克隆。
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3.发明授权Neutrophil chemotactic factor cloned cDNA and monoclonal antibodies thereto 有权嗜中性粒细胞趋化因子克隆了cDNA及其单克隆抗体公开(公告)号：US06475741B1
公开(公告)日：2002-11-05
申请号：US10037218
申请日：2001-11-09
申请人： Kouji Matsushima , Teizo Yoshimura , Edward J. Leonard , Joost Oppenheim , Ettore Appella , Stephen D. Showalter
发明人： Kouji Matsushima , Teizo Yoshimura , Edward J. Leonard , Joost Oppenheim , Ettore Appella , Stephen D. Showalter
IPC分类号： C12Q168
CPC分类号： C07K14/5421 , A61K38/00 , C07K16/244 , Y10S435/81 , Y10S514/885 , Y10S930/12
摘要： An isolated, synthetic preparation of a novel neutrophil-specific chemotactic factor (NCF), monoclonal antibodies having specific binding affinity for NCF and a clone containing the complete cDNA coding sequence for NCF are disclosed.
摘要翻译： 公开了一种新型嗜中性粒细胞特异性趋化因子（NCF）的分离合成制剂，对NCF具有特异性结合亲和力的单克隆抗体和含NCF完整cDNA编码序列的克隆。
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公开(公告)号：US06376659B1
公开(公告)日：2002-04-23
申请号：US08818631
申请日：1997-03-14
申请人： Kouji Matsushima , Teizo Yoshimura , Edward J. Leonard , Joost Oppenheim , Ettore Appella , Stephen D. Showalter
发明人： Kouji Matsushima , Teizo Yoshimura , Edward J. Leonard , Joost Oppenheim , Ettore Appella , Stephen D. Showalter
IPC分类号： C12N1519
CPC分类号： C07K14/5421 , A61K38/00 , C07K16/244 , Y10S435/81 , Y10S514/885 , Y10S930/12
摘要： An isolated, synthetic preparation of a novel neutrophil-specific chemotactic factor (NCF), monoclonal antibodies having specific binding affinity of NCF and a clone containing the complete cDNA coding sequence for NCF are disclosed.
摘要翻译： 公开了一种新型嗜中性粒细胞特异性趋化因子（NCF）的分离合成制剂，具有NCF特异性结合亲和力的单克隆抗体和含有NCF完整cDNA编码序列的克隆。
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公开(公告)号：US5652338A
公开(公告)日：1997-07-29
申请号：US169033
申请日：1988-03-16
申请人： Kouji Matsushima , Teizo Yoshimura , Edward J. Leonard , Joost Oppenheim , Ettore Appella , Stephen D. Showalter
发明人： Kouji Matsushima , Teizo Yoshimura , Edward J. Leonard , Joost Oppenheim , Ettore Appella , Stephen D. Showalter
IPC分类号： G01N33/53 , A61K38/00 , A61K39/395 , A61P29/00 , C07K14/52 , C07K14/54 , C07K16/00 , C07K16/24 , C12N5/10 , C12N15/09 , C12N15/12 , C12N15/19 , C12P21/08 , C12Q1/68 , C12R1/91 , G01N33/577
CPC分类号： C07K14/5421 , C07K16/244 , A61K38/00 , Y10S435/81 , Y10S514/885 , Y10S930/12
摘要： An isolated, synthetic preparation of a novel neutrophil-specific chemotactic factor (NCF), monoclonal antibodies having specific binding affinity for NCF and a clone containing the complete cDNA coding sequence for NCF are disclosed.
摘要翻译： 公开了一种新型嗜中性粒细胞特异性趋化因子（NCF）的分离合成制剂，对NCF具有特异性结合亲和力的单克隆抗体和含NCF完整cDNA编码序列的克隆。
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6.发明授权Human derived monocyte attracting purified peptide products useful in a method of treating infection and neoplasms in a human body 失效人源性单核细胞吸引用于治疗人体感染和赘生物的方法中的纯化肽产物
公开(公告)号：US6090795A
公开(公告)日：2000-07-18
申请号：US686264
申请日：1991-04-15
CPC分类号： C07K14/523 , A61K38/00
摘要： Pure peptide products, derived from either human glioma cell line U-105MG or human peripheral blood mononuclear leukocytes are provided; the products have a molecular mass of about 8,400 daltons, and the products exhibit optimal monocyte chemotactic activity at a concentration of 1 nM. Methods of treating infection and neoplasms in a human body with the peptide products are additionally provided, as well as pharmaceutical compositions for the peptide products.
摘要翻译： 提供衍生自人神经胶质瘤细胞系U-105MG或人外周血单核白细胞的纯肽产物; 产物具有约8400道尔顿的分子量，并且产物在1nM的浓度下表现出最佳的单核细胞趋化活性。 还提供了利用肽产物治疗人体感染和肿瘤的方法以及肽产品的药物组合物。
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7.发明授权Human derived monocyte attracting purified protein product useful in a method of treating infection and neoplasms in a human body 失效人源性单核细胞吸引纯化的蛋白质产物，可用于治疗人体感染和赘生物的方法
公开(公告)号：US5714578A
公开(公告)日：1998-02-03
申请号：US466280
申请日：1995-06-06
CPC分类号： C07K14/523 , A61K38/00
摘要： Pure peptide products, derived from either human glioma cell line U-105MG or human peripheral blood mononuclear leukocytes are provided; the products have a molecular mass of about 8,400 daltons, and the products exhibit optimal monocyte chemotactic activity at a concentration of 1 nM. Methods of treating infection and neoplasms in a human body with such peptides and monocyte chemoattractant products are additionally provided, as well as pharmaceutical compositions for the same.
摘要翻译： 提供衍生自人神经胶质瘤细胞系U-105MG或人外周血单核白细胞的纯肽产物; 产物具有约8400道尔顿的分子量，并且产物在1nM的浓度下表现出最佳的单核细胞趋化活性。 此外还提供了用这种肽和单核细胞趋化剂产物治疗人体感染和肿瘤的方法，以及用于其的药物组合物。
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8.发明授权Process for preparing human derived monocyte attracting purified peptide products useful in a method of treating infection and neoplasms in a human body 失效用于制备人源性单核细胞的方法，其吸引用于治疗人体感染和赘生物的方法中的纯化肽产物
公开(公告)号：US5532144A
公开(公告)日：1996-07-02
申请号：US449552
申请日：1995-05-24
CPC分类号： C07K14/523 , A61K38/00
摘要： Pure peptide products, derived from either human glioma cell line U-105MG or human peripheral blood mononuclear leukocytes are provided; the products have a molecular mass of about 8,400 daltons, and the products exhibit optimal monocyte chemotactic activity at a concentration of 1 nM. Methods of treating infection and neoplasms in a human body with the peptide products are additionally provided, as well as pharmaceutical compositions for the peptide products.
摘要翻译： 提供衍生自人神经胶质瘤细胞系U-105MG或人外周血单核白细胞的纯肽产物; 产物具有约8400道尔顿的分子量，并且产物在1nM的浓度下表现出最佳的单核细胞趋化活性。 还提供了利用肽产物治疗人体感染和肿瘤的方法以及肽产品的药物组合物。
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9.发明授权Human derived monocyte attracting purified protein product useful in a method of treating infection and neoplasms in a human body, and the cloning of full length cDNA thereof 有权人源性单核细胞吸引用于治疗人体感染和赘生物的方法的纯化蛋白质产物，以及克隆其全长cDNA公开(公告)号：US07319091B2
公开(公告)日：2008-01-15
申请号：US11055587
申请日：2005-02-08
IPC分类号： C07K14/00
CPC分类号： C07K14/523 , A61K38/00
摘要： Pure peptide products, derived from either human glioma cell line U-105MG or human peripheral blood mononuclear leukocytes are provided; the products have a molecular mass of about 8,400 daltons, and the products exhibit optimal monocyte chemotactic activity at a concentration of 1 nM. The cloning of full length cDNA for the peptide products is also provided, as well as recombinant methods for the production of monocyte chemoattractant products. Methods of treating infection and neoplasms in a human body with such peptides and monocyte chemoattractant products are additionally provided, as well as pharmaceutical compositions for the same.
摘要翻译： 提供衍生自人神经胶质瘤细胞系U-105MG或人外周血单核白细胞的纯肽产物; 产物具有约8400道尔顿的分子量，并且产物在1nM的浓度下表现出最佳的单核细胞趋化活性。 还提供了用于肽产物的全长cDNA的克隆，以及用于生产单核细胞趋化因子产物的重组方法。 此外还提供了用这种肽和单核细胞趋化剂产物治疗人体感染和肿瘤的方法，以及用于其的药物组合物。
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10.发明授权Human derived monocyte attracting purified protein product useful in a method of treating infection and neoplasms in a human body, and the cloning of full length cDNA thereof 失效人源性单核细胞吸引用于治疗人体感染和赘生物的方法的纯化蛋白质产物，以及克隆其全长cDNA公开(公告)号：US06869924B1
公开(公告)日：2005-03-22
申请号：US07330446
申请日：1989-03-30
CPC分类号： C07K14/523 , A61K38/00
摘要： Pure peptide products, derived from either human glioma cell line U-105MG or human peripheral blood mononuclear leukocytes are provided; the products have a molecular mass of about 8,400 daltons, and the products exhibit optimal monocyte chemotactic activity at a concentration of 1 nM. The cloning of full length cDNA for the peptide products is also provided, as well as recombinant methods for the production of monocyte chemoattractant products. Methods of treating infection and neoplasms in a human body with such peptides and monocyte chemoattractant products are additionally provided, as well as pharmaceutical compositions for the same.
摘要翻译： 提供衍生自人神经胶质瘤细胞系U-105MG或人外周血单核白细胞的纯肽产物; 产物具有约8400道尔顿的分子量，并且产物在1nM的浓度下表现出最佳的单核细胞趋化活性。 还提供了用于肽产物的全长cDNA的克隆，以及用于生产单核细胞趋化因子产物的重组方法。 另外提供了用这种肽和单核细胞趋化物质产物治疗人体感染和肿瘤的方法，以及用于其的药物组合物。
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