Gene encoding protein from merozoite of Babesia caballi, recombinant protein obtained with said gene and use thereof
    10.
    发明授权
    Gene encoding protein from merozoite of Babesia caballi, recombinant protein obtained with said gene and use thereof 失效
    来自Babesia caballi的裂殖子的基因编码蛋白,用该基因获得的重组蛋白及其用途

    公开(公告)号:US07326543B2

    公开(公告)日:2008-02-05

    申请号:US10863338

    申请日:2004-06-09

    摘要: The present invention provides a gene encoding a protein from merozoite of Babesia caballi, a recombinant protein of Babesia caballi, and an antibody capable specifically binding to a 48 kDa protein of rhoptry of Babesia caballi merozoite. In accordance with the present invention, it is possible to stably prepare the 48 kDa protein of rhoptry of Babesia caballi and the gene encoding said protein in a large amount with the recombinant DNA technique. The present invention also provides a method for diagnosing equine babesiasis which comprises either specifically detecting anti-Babesia caballi antibody present in equine blood by using the recombinant protein of present invention as an antigen or detecting the presence of Babesia caballi merozoite in equine blood by using the antibody of the present invention.

    摘要翻译: 本发明提供了编码来自巴贝虫(Babesia caballi)的重组蛋白的巴贝虫(Babesia caballi)的裂殖子的蛋白质和能够特异性结合巴贝虫裂殖子的48kDa蛋白质的抗体的基因。 根据本发明,可以通过重组DNA技术稳定地制备巴贝氏菌的48kDa蛋白质和大量编码所述蛋白质的基因。 本发明还提供了一种用于诊断马贝氏病的方法,其特征在于,通过使用本发明的重组蛋白作为抗原或者通过使用本发明的马血中的巴贝虫突变体的存在来特异性检测马血中存在的抗巴贝虫抗体 本发明的抗体。