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    Preparation of functional gel particles with a dual crosslink network
    1.
    发明申请
    Preparation of functional gel particles with a dual crosslink network 有权
    用双交联网络制备功能性凝胶颗粒

    公开(公告)号：US20100143286A1

    公开(公告)日：2010-06-10

    申请号：US12311673

    申请日：2007-10-09

    申请人： Krzystof Matyjaszewski ,  Ke Min ,  Jung Kwon Oh ,  James Spanswick ,  Nicolay V. Tsarevsky

    发明人： Krzystof Matyjaszewski ,  Ke Min ,  Jung Kwon Oh ,  James Spanswick ,  Nicolay V. Tsarevsky

    IPC分类号： A61K31/74 ,  C08K11/00 ,  A61K8/72

    CPC分类号： C08F293/005 ,  C08F283/00 ,  C08F290/00 ,  C08F290/06 ,  C08F291/00

    摘要： Functional gel particle formed from a crosslinked polymeric network including a fraction of stable crosslinks and a second fraction of cleavable crosslinks are disclosed. Functional compounds may be chemically or physically encapsulated within and/or released from the gel particle by selective cleavage of the cleavable crosslinks. The functional compounds may be delivered and released to a pre-selected target site. Peripheral or other accessible functionality on the surface of the gel particle allows attachment of a surface reactive agent, thereby modifying one or more surface properties of the gel particle. Processes of preparing the gel particles and processes of delivering the functional compounds to a target site are also disclosed.

    摘要翻译： 公开了由交联的聚合物网络形成的功能性凝胶颗粒，其包括稳定的交联部分和可切割交联的第二部分。 官能化合物可以通过选择性裂解可切割交联而化学或物理地包封在凝胶颗粒内和/或从凝胶颗粒释放。 功能性化合物可以被递送并释放到预先选择的靶位点。 在凝胶颗粒表面上的周边或其他可接近的功能允许附着表面活性剂，从而改变凝胶颗粒的一个或多个表面性质。 还公开了制备凝胶颗粒的方法和将功能性化合物递送至靶位点的方法。

    Preparation of functional gel particles with a dual crosslink network
    2.
    发明授权
    Preparation of functional gel particles with a dual crosslink network 有权
    用双交联网络制备功能性凝胶颗粒

    公开(公告)号：US08367051B2

    公开(公告)日：2013-02-05

    申请号：US12311673

    申请日：2007-10-09

    申请人： Krzysztof Matyjaszewski ,  Ke Min ,  Jung Kwon Oh ,  James Spanswick ,  Nicolay V. Tsarevsky

    发明人： Krzysztof Matyjaszewski ,  Ke Min ,  Jung Kwon Oh ,  James Spanswick ,  Nicolay V. Tsarevsky

    IPC分类号： A61K9/14 ,  A61K31/74

    CPC分类号： C08F293/005 ,  C08F283/00 ,  C08F290/00 ,  C08F290/06 ,  C08F291/00

    摘要： Functional gel particle formed from a crosslinked polymeric network including a fraction of stable crosslinks and a second fraction of cleavable crosslinks are disclosed. Functional compounds may be chemically or physically encapsulated within and/or released from the gel particle by selective cleavage of the cleavable crosslinks. The functional compounds may be delivered and released to a pre-selected target site. Peripheral or other accessible functionality on the surface of the gel particle allows attachment of a surface reactive agent, thereby modifying one or more surface properties of the gel particle. Processes of preparing the gel particles and processes of delivering the functional compounds to a target site are also disclosed.

    摘要翻译： 公开了由交联的聚合物网络形成的功能性凝胶颗粒，其包括稳定的交联部分和可切割交联的第二部分。 官能化合物可以通过选择性裂解可切割交联而化学或物理地包封在凝胶颗粒内和/或从凝胶颗粒释放。 功能性化合物可以被递送并释放到预先选择的靶位点。 在凝胶颗粒表面上的周边或其他可接近的功能允许附着表面活性剂，从而改变凝胶颗粒的一个或多个表面性质。 还公开了制备凝胶颗粒的方法和将功能性化合物递送至靶位点的方法。