公开(公告)号：US08367051B2

公开(公告)日：2013-02-05

申请号：US12311673

申请日：2007-10-09

申请人： Krzysztof Matyjaszewski ,  Ke Min ,  Jung Kwon Oh ,  James Spanswick ,  Nicolay V. Tsarevsky

发明人： Krzysztof Matyjaszewski ,  Ke Min ,  Jung Kwon Oh ,  James Spanswick ,  Nicolay V. Tsarevsky

IPC分类号： A61K9/14 ,  A61K31/74

CPC分类号： C08F293/005 ,  C08F283/00 ,  C08F290/00 ,  C08F290/06 ,  C08F291/00

摘要： Functional gel particle formed from a crosslinked polymeric network including a fraction of stable crosslinks and a second fraction of cleavable crosslinks are disclosed. Functional compounds may be chemically or physically encapsulated within and/or released from the gel particle by selective cleavage of the cleavable crosslinks. The functional compounds may be delivered and released to a pre-selected target site. Peripheral or other accessible functionality on the surface of the gel particle allows attachment of a surface reactive agent, thereby modifying one or more surface properties of the gel particle. Processes of preparing the gel particles and processes of delivering the functional compounds to a target site are also disclosed.

摘要翻译： 公开了由交联的聚合物网络形成的功能性凝胶颗粒，其包括稳定的交联部分和可切割交联的第二部分。 官能化合物可以通过选择性裂解可切割交联而化学或物理地包封在凝胶颗粒内和/或从凝胶颗粒释放。 功能性化合物可以被递送并释放到预先选择的靶位点。 在凝胶颗粒表面上的周边或其他可接近的功能允许附着表面活性剂，从而改变凝胶颗粒的一个或多个表面性质。 还公开了制备凝胶颗粒的方法和将功能性化合物递送至靶位点的方法。

公开(公告)号：US08404788B2

公开(公告)日：2013-03-26

申请号：US13026919

申请日：2011-02-14

申请人： Krzysztof Matyjaszewski ,  Lindsay Bombalski ,  Wojciech Jakubowski ,  Ke Min ,  Nicolay V. Tsarevsky ,  James Spanswick

发明人： Krzysztof Matyjaszewski ,  Lindsay Bombalski ,  Wojciech Jakubowski ,  Ke Min ,  Nicolay V. Tsarevsky ,  James Spanswick

IPC分类号： C08F4/40

CPC分类号： C08F265/04 ,  C08F4/40 ,  C08F220/18 ,  C08F265/00 ,  C08F291/00 ,  C08F293/00 ,  C08F293/005 ,  C08F2438/01

摘要： Embodiments of the polymerization process of the present invention are directed to polymerizing free radically polymerizable monomers in the presence of a polymerization medium initially comprising at least one transition metal catalyst and an atom transfer radical polymerization initiator. The polymerization medium may additionally comprise a reducing agent. The reducing agent may be added initially or during the polymerization process in a continuous or intermittent manner. The polymerization process may further comprises reacting the reducing agent with at least one of the transition metal catalyst in an oxidized state and a compound comprising a radically transferable atom or group to form a compound that does not participate significantly in control of the polymerization process. Embodiments of the present invention comprise reacting a reducing agent with at least one of catalyst in an oxidized state and a compound comprising a radically transferable atom or group to initiate and/or maintain catalytic activity throughout the polymerization process.

摘要翻译： 本发明的聚合方法的实施方案涉及在最初包含至少一种过渡金属催化剂和原子转移自由基聚合引发剂的聚合介质的存在下使可自由基聚合的单体聚合。 聚合介质可另外包含还原剂。 还原剂可以以连续或间歇的方式最初或在聚合过程中加入。 聚合方法可以进一步包括使还原剂与氧化态的至少一种过渡金属催化剂和包含可自由基转移的原子或基团的化合物反应，以形成不显着控制聚合过程的化合物。 本发明的实施方案包括使还原剂与氧化状态的催化剂和包含可自由基转移的原子或基团的化合物中的至少一种反应，以在整个聚合过程中引发和/或维持催化活性。

公开(公告)号：US07893174B2

公开(公告)日：2011-02-22

申请号：US10591426

申请日：2005-03-07

申请人： Krzysztof Matyjaszewski ,  Lindsay Bombalski ,  Wojciech Jakubowski ,  Ke Min ,  James Spanswick ,  Nicolay V. Tsarevsky

发明人： Krzysztof Matyjaszewski ,  Lindsay Bombalski ,  Wojciech Jakubowski ,  Ke Min ,  James Spanswick ,  Nicolay V. Tsarevsky

IPC分类号： C08F4/40

CPC分类号： C08F265/04 ,  C08F4/40 ,  C08F220/18 ,  C08F265/00 ,  C08F291/00 ,  C08F293/00 ,  C08F293/005 ,  C08F2438/01

摘要： Embodiments of the polymerization process of the present invention are directed to polymerizing free radically polymerizable monomers in the presence of a polymerization medium initially comprising at least one transition metal catalyst and an atom transfer radical polymerization initiator. The polymerization medium may additionally comprise a reducing agent. The reducing agent may be added initially or during the polymerization process in a continuous or intermittent manner. The polymerization process may further comprise reacting the reducing agent with at least one of the transition metal catalyst in an oxidized state and a compound comprising a radically transferable atom or group to form a compound that does not participate significantly in control of the polymerization process. Embodiments of the present invention comprise reacting a reducing agent with at least one of catalyst in an oxidized state and a compound comprising a radically transferable atom or group to initiate and/or maintain catalytic activity throughout the polymerization process.

摘要翻译： 本发明的聚合方法的实施方案涉及在最初包含至少一种过渡金属催化剂和原子转移自由基聚合引发剂的聚合介质的存在下使可自由基聚合的单体聚合。 聚合介质可另外包含还原剂。 还原剂可以以连续或间歇的方式最初或在聚合过程中加入。 聚合方法还可包括使还原剂与氧化态的至少一种过渡金属催化剂和包含可自由基转移的原子或基团的化合物反应，以形成不显着控制聚合方法的化合物。 本发明的实施方案包括使还原剂与氧化状态的催化剂和包含可自由基转移的原子或基团的化合物中的至少一种反应，以在整个聚合过程中引发和/或维持催化活性。

公开(公告)号：US20110218306A1

公开(公告)日：2011-09-08

申请号：US13026919

申请日：2011-02-14

申请人： Krzysztof Matyjaszewski ,  Lindsay Bombalski ,  Wojciech Jakubowski ,  Ke Min ,  James Spanswick ,  Nicolay V. Tsarevsky

发明人： Krzysztof Matyjaszewski ,  Lindsay Bombalski ,  Wojciech Jakubowski ,  Ke Min ,  James Spanswick ,  Nicolay V. Tsarevsky

IPC分类号： C08F120/06 ,  C08F112/08 ,  C08F118/02 ,  C08G63/08

CPC分类号： C08F265/04 ,  C08F4/40 ,  C08F220/18 ,  C08F265/00 ,  C08F291/00 ,  C08F293/00 ,  C08F293/005 ,  C08F2438/01

摘要： Embodiments of the polymerization process of the present invention are directed to polymerizing free radically polymerizable monomers in the presence of a polymerization medium initially comprising at least one transition metal catalyst and an atom transfer radical polymerization initiator. The polymerization medium may additionally comprise a reducing agent. The reducing agent may be added initially or during the polymerization process in a continuous or intermittent manner. The polymerization process may further comprises reacting the reducing agent with at least one of the transition metal catalyst in an oxidized state and a compound comprising a radically transferable atom or group to form a compound that does not participate significantly in control of the polymerization process. Embodiments of the present invention comprise reacting a reducing agent with at least one of catalyst in an oxidized state and a compound comprising a radically transferable atom or group to initiate and/or maintain catalytic activity throughout the polymerization process.

摘要翻译： 本发明的聚合方法的实施方案涉及在最初包含至少一种过渡金属催化剂和原子转移自由基聚合引发剂的聚合介质的存在下使可自由基聚合的单体聚合。 聚合介质可另外包含还原剂。 还原剂可以以连续或间歇的方式最初或在聚合过程中加入。 聚合方法可以进一步包括使还原剂与氧化态的至少一种过渡金属催化剂和包含可自由基转移的原子或基团的化合物反应，以形成不显着控制聚合过程的化合物。 本发明的实施方案包括使还原剂与氧化状态的催化剂和包含可自由基转移的原子或基团的化合物中的至少一种反应，以在整个聚合过程中引发和/或维持催化活性。

公开(公告)号：US20100143286A1

公开(公告)日：2010-06-10

申请号：US12311673

申请日：2007-10-09

申请人： Krzystof Matyjaszewski ,  Ke Min ,  Jung Kwon Oh ,  James Spanswick ,  Nicolay V. Tsarevsky

发明人： Krzystof Matyjaszewski ,  Ke Min ,  Jung Kwon Oh ,  James Spanswick ,  Nicolay V. Tsarevsky

IPC分类号： A61K31/74 ,  C08K11/00 ,  A61K8/72

CPC分类号： C08F293/005 ,  C08F283/00 ,  C08F290/00 ,  C08F290/06 ,  C08F291/00

摘要： Functional gel particle formed from a crosslinked polymeric network including a fraction of stable crosslinks and a second fraction of cleavable crosslinks are disclosed. Functional compounds may be chemically or physically encapsulated within and/or released from the gel particle by selective cleavage of the cleavable crosslinks. The functional compounds may be delivered and released to a pre-selected target site. Peripheral or other accessible functionality on the surface of the gel particle allows attachment of a surface reactive agent, thereby modifying one or more surface properties of the gel particle. Processes of preparing the gel particles and processes of delivering the functional compounds to a target site are also disclosed.

摘要翻译： 公开了由交联的聚合物网络形成的功能性凝胶颗粒，其包括稳定的交联部分和可切割交联的第二部分。 官能化合物可以通过选择性裂解可切割交联而化学或物理地包封在凝胶颗粒内和/或从凝胶颗粒释放。 功能性化合物可以被递送并释放到预先选择的靶位点。 在凝胶颗粒表面上的周边或其他可接近的功能允许附着表面活性剂，从而改变凝胶颗粒的一个或多个表面性质。 还公开了制备凝胶颗粒的方法和将功能性化合物递送至靶位点的方法。

公开(公告)号：US20100273906A1

公开(公告)日：2010-10-28

申请号：US12451581

申请日：2008-05-23

申请人： Krzysztof Matyjaszewski ,  Ke Min ,  James Spanswick

发明人： Krzysztof Matyjaszewski ,  Ke Min ,  James Spanswick

IPC分类号： C08J9/00 ,  C08F36/20

CPC分类号： C08F12/08 ,  C08F2/14 ,  C08F2/38 ,  C08F212/36 ,  C08F2438/01

摘要： The present disclosure describes a two-step batch dispersion polymerization process for the preparation of substantially uniformed-sized functional (co)polymer particles. The first step of the process includes polymerizing at least one first radically (co)polymerizable monomer by a free radical polymerization process to form a (co)polymer in a stable colloidal dispersion and the second step includes polymerizing the at first radically (co)polymerizable monomer or an additional radically (co)polymerizable monomer in the stable colloidal dispersion by a living/controlled radical (co)polymerization process.

摘要翻译： 本公开描述了用于制备基本上均匀尺寸的功能（共）聚合物颗粒的两步间歇分散聚合方法。 该方法的第一步包括通过自由基聚合方法聚合至少一种第一自由基（共）可聚合单体，以在稳定的胶态分散体中形成（共）聚合物，第二步包括首先从根本上聚合（共）可聚合 单体或通过活/受控自由基（共）聚合方法在稳定的胶体分散体中的另外的自由基（共）可聚合单体。

公开(公告)号：US20070276101A1

公开(公告)日：2007-11-29

申请号：US10591426

申请日：2005-03-07

申请人： Krzysztof Matyjaszewski ,  Lindsay Bombalski ,  Wojciech Jakubowski ,  Ke Min ,  James Spanswick ,  Nicolay Tsarevsky

发明人： Krzysztof Matyjaszewski ,  Lindsay Bombalski ,  Wojciech Jakubowski ,  Ke Min ,  James Spanswick ,  Nicolay Tsarevsky

IPC分类号： C08F251/00 ,  C08F4/06 ,  C08F8/00

CPC分类号： C08F265/04 ,  C08F4/40 ,  C08F220/18 ,  C08F265/00 ,  C08F291/00 ,  C08F293/00 ,  C08F293/005 ,  C08F2438/01

摘要： Embodiments of the polymerization process of the present invention are directed to polymerizing free radically polymerizable monomers in the presence of a polymerization medium initially comprising at least one transition metal catalyst and an atom transfer radical polymerization initiator. The polymerization medium may additionally comprise a reducing agent. The reducing agent may be added initially or during the polymerization process in a continuous or intermittent manner. The polymerization process may further comprise reacting the reducing agent with at least one of the transition metal catalyst in an oxidized state and a compound comprising a radically transferable atom or group to form a compound that does not participate significantly in control of the polymerization process. Embodiments of the present invention comprise reacting a reducing agent with at least one of catalyst in an oxidized state and a compound comprising a radically transferable atom or group to initiate and/or maintain catalytic activity throughout the polymerization process.

摘要翻译： 本发明的聚合方法的实施方案涉及在最初包含至少一种过渡金属催化剂和原子转移自由基聚合引发剂的聚合介质的存在下使可自由基聚合的单体聚合。 聚合介质可另外包含还原剂。 还原剂可以以连续或间歇的方式最初或在聚合过程中加入。 聚合方法还可包括使还原剂与氧化态的至少一种过渡金属催化剂和包含可自由基转移的原子或基团的化合物反应，以形成不显着控制聚合方法的化合物。 本发明的实施方案包括使还原剂与氧化状态的催化剂和包含可自由基转移的原子或基团的化合物中的至少一种反应，以在整个聚合过程中引发和/或维持催化活性。

公开(公告)号：US08252880B2

公开(公告)日：2012-08-28

申请号：US12451581

申请日：2008-05-23

申请人： Krzysztof Matyjaszewski ,  Ke Min ,  James Spanswick

发明人： Krzysztof Matyjaszewski ,  Ke Min ,  James Spanswick

IPC分类号： C08F4/00 ,  C08F2/00 ,  C08F4/28 ,  C08F210/00 ,  C08F36/00

CPC分类号： C08F12/08 ,  C08F2/14 ,  C08F2/38 ,  C08F212/36 ,  C08F2438/01

摘要： The present disclosure describes a two-step batch dispersion polymerization process for the preparation of substantially uniformed-sized functional (co)polymer particles. The first step of the process includes polymerizing at least one first radically (co)polymerizable monomer by a free radical polymerization process to form a (co)polymer in a stable colloidal dispersion and the second step includes polymerizing the at first radically (co)polymerizable monomer or an additional radically (co)polymerizable monomer in the stable colloidal dispersion by a living/controlled radical (co)polymerization process.

摘要翻译： 本公开描述了用于制备基本上均匀尺寸的功能（共）聚合物颗粒的两步间歇分散聚合方法。 该方法的第一步包括通过自由基聚合方法聚合至少一种第一自由基（共）可聚合单体，以在稳定的胶态分散体中形成（共）聚合物，第二步包括首先从根本上聚合（共）可聚合 单体或通过活/受控自由基（共）聚合方法在稳定的胶体分散体中的另外的自由基（共）可聚合单体。

公开(公告)号：US20090176951A1

公开(公告)日：2009-07-09

申请号：US11990836

申请日：2006-08-23

申请人： Krzysztof Matyjaszewski ,  Ke Min

发明人： Krzysztof Matyjaszewski ,  Ke Min

IPC分类号： C08F2/22

CPC分类号： C08F4/40 ,  C08F2/22 ,  C08F212/08 ,  C08F293/00 ,  C08F293/005 ,  C08F2438/01 ,  C08F220/12

摘要： The invention is directed to a microemulsion polymerization comprising adding a polymerization catalyst precursor, such as a transition metal complex in the higher of two accessible oxidation states, an ATRP initiator, and an organic solvent to an aqueous solution to form an emulsion. Radically polymerizable monomers and a reducing agent may then be added to the emulsion. The reducing agent converts the catalyst precursor to a catalyst for polymerization of the first monomer from the initiator. In certain embodiments the organic solvent may comprise radically polymerizable monomers. The aqueous solution may comprise a surfactant. Further embodiments are directed to an ah initio polymerization process comprising adding a polymerization catalyst precursor; an ATRP initiator, and an organic solvent to an aqueous solution to form an emulsion, wherein the organic solvent comprises second radically polymerizable monomers, adding a reducing agent to convert the catalyst precursor to a catalyst for polymerization of the first radically polymerizable monomer from the initiator; and adding first radically polymerizable monomers to the emulsion.

摘要翻译： 本发明涉及一种微乳液聚合方法，其中包括将聚合催化剂前体，例如两种可接近的氧化态中较高的过渡金属络合物，ATRP引发剂和有机溶剂加入到水溶液中以形成乳液。 然后将可自由基聚合的单体和还原剂加入到乳液中。 还原剂将催化剂前体转化为第一单体从引发剂聚合的催化剂。 在某些实施方案中，有机溶剂可以包含可自由基聚合的单体。 水溶液可以包含表面活性剂。 进一步的实施方案涉及一种开始聚合方法，包括加入聚合催化剂前体; ATRP引发剂和有机溶剂加入到水溶液中以形成乳液，其中有机溶剂包括第二自由基聚合单体，加入还原剂以将催化剂前体转化为用于从引发剂聚合第一可自由基聚合单体的催化剂 ; 并将第一可自由基聚合的单体加入到乳液中。

公开(公告)号：US08273823B2

公开(公告)日：2012-09-25

申请号：US11990836

申请日：2006-08-23

申请人： Krzysztof Matyjaszewski ,  Ke Min

发明人： Krzysztof Matyjaszewski ,  Ke Min

IPC分类号： C08F2/32 ,  C08F297/00 ,  C08F2/22 ,  C08F4/10

CPC分类号： C08F4/40 ,  C08F2/22 ,  C08F212/08 ,  C08F293/00 ,  C08F293/005 ,  C08F2438/01 ,  C08F220/12

摘要： The invention is directed to a microemulsion polymerization comprising adding a polymerization catalyst precursor, such as a transition metal complex in the higher of two accessible oxidation states, an ATRP initiator, and an organic solvent to an aqueous solution to form an emulsion. Radically polymerizable monomers and a reducing agent may then be added to the emulsion. The reducing agent converts the catalyst precursor to a catalyst for polymerization of the first monomer from the initiator. In certain embodiments the organic solvent may comprise radically polymerizable monomers. The aqueous solution may comprise a surfactant. Further embodiments are directed to an ah initio polymerization process comprising adding a polymerization catalyst precursor; an ATRP initiator, and an organic solvent to an aqueous solution to form an emulsion, wherein the organic solvent comprises second radically polymerizable monomers, adding a reducing agent to convert the catalyst precursor to a catalyst for polymerization of the first radically polymerizable monomer from the initiator; and adding first radically polymerizable monomers to the emulsion.

摘要翻译： 本发明涉及一种微乳液聚合方法，其中包括将聚合催化剂前体，例如两种可接近的氧化态中较高的过渡金属络合物，ATRP引发剂和有机溶剂加入到水溶液中以形成乳液。 然后将可自由基聚合的单体和还原剂加入到乳液中。 还原剂将催化剂前体转化为第一单体从引发剂聚合的催化剂。 在某些实施方案中，有机溶剂可以包含可自由基聚合的单体。 水溶液可以包含表面活性剂。 进一步的实施方案涉及一种开始聚合方法，包括加入聚合催化剂前体; ATRP引发剂和有机溶剂加入到水溶液中以形成乳液，其中有机溶剂包括第二自由基聚合单体，加入还原剂以将催化剂前体转化为用于从引发剂聚合第一可自由基聚合单体的催化剂 ; 并将第一可自由基聚合的单体加入到乳液中。