公开(公告)号：US20150119579A1

公开(公告)日：2015-04-30

申请号：US14394126

申请日：2013-03-05

申请人： Kureha Corporation

发明人： Takashi Oohashi ,  Nobuyuki Araki ,  Takashi Shimokawara

IPC分类号： C07D249/08

CPC分类号： C07D249/08

摘要： Generation of by-product is reduced by producing a triazolylmethyl cycloalkanol derivative by reacting a cycloalkanone derivative and an alkali metal salt of 1,2,4-triazole in the presence of a sulfur ylide at a reaction temperature of higher than 110° C. and 140° C. or lower.

摘要翻译： 在反应温度高于110℃的硫叶立德的存在下，通过使环烷酮衍生物与1,2,4-三唑的碱金属盐反应制备三唑基甲基环烷醇衍生物，从而减少副产物的产生， 140℃以下。

公开(公告)号：US20140315967A1

公开(公告)日：2014-10-23

申请号：US14359449

申请日：2012-11-16

申请人： Kureha Corporation

发明人： Nobuyuki Araki ,  Taiji Miyake ,  Emiko Obata

IPC分类号： C07D249/08 ,  A01N43/653

CPC分类号： C07D249/08 ,  A01N43/50 ,  A01N43/653

摘要： In order to provide a compound which exhibits a high controlling effect against plant diseases and is able to reduce phytotoxicity, the present invention is a triazole derivative represented by General Formula (I), the azole derivative being a (−)-enantiomer or (+)-enantiomer having an —R1 group, hydroxy group, and substituted or unsubstituted benzyl group bonded to a cyclopentane ring in cis-form.

摘要翻译： 本发明为通式（I）表示的三唑衍生物，为（ - ） - 对映异构体或（+） - 对映异构体的唑类衍生物，为了提供对植物病害具有高控制效果且能够降低植物毒性的化合物， ） - 对映异构体，其具有-R1基团，羟基和与顺式环戊烷环键合的取代或未取代的苄基。

公开(公告)号：US09750254B2

公开(公告)日：2017-09-05

申请号：US15037534

申请日：2014-10-08

申请人： Kureha Corporation

发明人： Taiji Miyake ,  Nobuyuki Araki

IPC分类号： A01N43/653 ,  A01N43/50 ,  C07D249/08 ,  A01N37/50 ,  A01N43/40 ,  A01N43/54 ,  A01N43/88 ,  A01N47/22

CPC分类号： A01N43/653 ,  A01N37/50 ,  A01N43/40 ,  A01N43/50 ,  A01N43/54 ,  A01N43/88 ,  A01N47/22 ,  C07D249/08 ,  A01N47/24

摘要： An agricultural or horticultural chemical according to the present invention is an agricultural or horticultural chemical containing a plurality of active ingredients, the agricultural or horticultural chemical comprises, as one of the active ingredients, an azole derivative represented by general formula (I) below, and can be used as a plant disease controlling agent that can reduce the content of an active ingredient: wherein, R1 represents an alkyl group having from 1 to 6 carbons, R2 represents a hydrogen atom, an alkyl group having from 1 to 3 carbons, an alkenyl group or an alkynyl group having from 2 to 3 carbons, A represents a nitrogen atom or a methine group, Y1 represents a halogen atom, and n represents either 0 or 1.

公开(公告)号：US09162966B2

公开(公告)日：2015-10-20

申请号：US14213240

申请日：2014-03-14

申请人： KUREHA CORPORATION

发明人： Nobuyuki Araki ,  Toru Yamazaki ,  Nobuyuki Kusano ,  Eiyu Imai ,  Hisashi Kanno ,  Masaru Mori ,  Taiji Miyake

IPC分类号： C07C61/06 ,  C07C67/31 ,  C07D405/06 ,  A01N37/10 ,  A01N43/50 ,  A01N43/653 ,  C07C201/12

CPC分类号： C07C67/31 ,  A01N37/10 ,  A01N43/50 ,  A01N43/653 ,  C07C201/12 ,  C07C2601/08 ,  C07D405/06

摘要： A method of producing an azole derivative according to the invention represented by Formula (XI) wherein R1 denotes a C1-C6 alkyl group, a C2-C6 alkenyl group or a C2-C6 alkynyl group; R2 denotes a C1-C4 alkyl group; each Y denotes a halogen atom, a C1-C4 alkyl group, a C1-C4 haloalkyl group, a C1-C4 alkoxy group, a C1-C4 haloalkoxy group, a phenyl group, a cyano group or a nitro group; and m denotes 0 to 5; when m is 2 or more, each Y may be the same or different. As a result, an azole derivative contained as an active ingredient in an agro-horticultural agent having an excellent controlling effect on diseases can be provided.

摘要翻译： 制备式（Ⅺ）表示的本发明唑类衍生物的方法，其中R1表示C1-C6烷基，C2-C6链烯基或C2-C6炔基; R2表示C1-C4烷基; 每个Y表示卤素原子，C1-C4烷基，C1-C4卤代烷基，C1-C4烷氧基，C1-C4卤代烷氧基，苯基，氰基或硝基; m表示0〜5; 当m为2以上时，Y可以相同也可以不同。 结果，可以提供在对疾病具有优异控制作用的农业园艺剂中作为活性成分含有的唑衍生物。

公开(公告)号：US20150051424A1

公开(公告)日：2015-02-19

申请号：US14396231

申请日：2013-03-06

申请人： Kureha Corporation

发明人： Takashi Oohashi ,  Nobuyuki Araki

IPC分类号： C07C315/04

CPC分类号： C07C315/04 ,  C07C381/00

摘要： The present invention relates to a method of producing trimethylsulfoxonium bromide by reacting dimethyl sulfoxide with methyl bromide (MeBr), wherein MeBr is added in a manner that satisfies conditions (1) and (2): (1) MeBr is added at an addition rate that complies with a predetermined feeding profile, (2) MeBr is added upon the temperature in the reaction system reaching a predetermined maximum temperature.

摘要翻译： 本发明涉及通过使二甲基亚砜与甲基溴（MeBr）反应生成三甲基氧化锍溴化物的方法，其中MeBr以满足条件（1）和（2）的方式加入：（1）以添加速率加入MeBr 符合预定的进料曲线，（2）在反应体系中的温度达到预定的最高温度时加入MeBr。

公开(公告)号：US09750255B2

公开(公告)日：2017-09-05

申请号：US15038574

申请日：2014-10-08

申请人： Kureha Corporation

发明人： Taiji Miyake ,  Nobuyuki Araki

IPC分类号： A01N43/653 ,  A01N43/50 ,  A01N43/84

CPC分类号： A01N43/653 ,  A01N43/50 ,  A01N43/84 ,  A01N43/40

摘要： An agricultural or horticultural chemical according to the present invention is an agricultural or horticultural chemical containing a plurality of active ingredients, the agricultural or horticultural chemical comprises, as one of the active ingredients, an azole derivative represented by general formula (I), and can be used as a plant disease controlling agent that can reduce the content of an active ingredient: wherein, R1 represents an alkyl group having from 1 to 6 carbons, R2 represents a hydrogen atom, an alkyl group having from 1 to 3 carbons, an alkenyl group or an alkynyl group having from 2 to 3 carbons, A represents a nitrogen atom or a methine group, Y1 represents a halogen atom, and n represents either 0 or 1.

公开(公告)号：US09145351B2

公开(公告)日：2015-09-29

申请号：US14213043

申请日：2014-03-14

申请人： KUREHA CORPORATION

发明人： Nobuyuki Araki ,  Toru Yamazaki ,  Nobuyuki Kusano ,  Eiyu Imai ,  Hisashi Kanno ,  Masaru Mori ,  Taiji Miyake

IPC分类号： C07C61/06 ,  C07C67/31 ,  C07D405/06 ,  A01N37/10 ,  A01N43/50 ,  A01N43/653 ,  C07C201/12

CPC分类号： C07C67/31 ,  A01N37/10 ,  A01N43/50 ,  A01N43/653 ,  C07C201/12 ,  C07C2601/08 ,  C07D405/06

摘要： An azole derivative according to the invention is represented by Formula (XI) wherein R1 denotes a C1-C6 alkyl group, a C2-C6 alkenyl group or a C2-C6 alkynyl group; R2 denotes a C1-C4 alkyl group; each Y denotes a halogen atom, a C1-C4 alkyl group, a C1-C4 haloalkyl group, a C1-C4 alkoxy group, a C1-C4 haloalkoxy group, a phenyl group, a cyano group or a nitro group; and m denotes 0 to 5; when m is 2 or more, each Y may be the same or different. As a result, an azole derivative contained as an active ingredient in an agro-horticultural agent having an excellent controlling effect on diseases can be provided.

摘要翻译： 根据本发明的唑衍​​生物由式（XI）表示，其中R1表示C1-C6烷基，C2-C6烯基或C2-C6炔基; R2表示C1-C4烷基; 每个Y表示卤素原子，C1-C4烷基，C1-C4卤代烷基，C1-C4烷氧基，C1-C4卤代烷氧基，苯基，氰基或硝基; m表示0〜5; 当m为2以上时，Y可以相同也可以不同。 结果，可以提供在对疾病具有优异控制作用的农业园艺剂中作为活性成分含有的唑衍生物。

公开(公告)号：US09814236B2

公开(公告)日：2017-11-14

申请号：US15035514

申请日：2014-10-08

申请人： Kureha Corporation

发明人： Taiji Miyake ,  Nobuyuki Araki

IPC分类号： A61K31/41 ,  A01N43/653 ,  A01N43/50 ,  A01N37/34 ,  A01N43/40 ,  A01N43/56 ,  A01N47/08

CPC分类号： A01N43/653 ,  A01N37/34 ,  A01N43/40 ,  A01N43/50 ,  A01N43/56 ,  A01N47/08 ,  A01N45/02 ,  A01N47/34

摘要： An agricultural or horticultural chemical according to the present invention is an agricultural or horticultural chemical containing a plurality of active ingredients, the agricultural or horticultural chemical comprises, as one of the active ingredients, an azole derivative represented by general formula (I) below, and can be used as a plant disease controlling agent that can reduce the content of an active ingredient, (In the general formula, R1 represents an alkyl group having from 1 to 6 carbons, R2 represents a hydrogen atom, an alkyl group having from 1 to 3 carbons, an alkenyl group or an alkynyl group having from 2 to 3 carbons, A represents a nitrogen atom or a methine group, Y1 represents a halogen atom, and n represents either 0 or 1).

公开(公告)号：US09440933B2

公开(公告)日：2016-09-13

申请号：US14691279

申请日：2015-04-20

申请人： KUREHA CORPORATION

发明人： Nobuyuki Araki ,  Taiji Miyake ,  Eiyu Imai ,  Emiko Obata

IPC分类号： C07D249/08 ,  C07D249/12 ,  C07D233/56 ,  A01N43/653 ,  C07D233/60 ,  C07D405/06 ,  A01N43/50 ,  A01N43/80 ,  C07D405/04

CPC分类号： C07D249/12 ,  A01N43/50 ,  A01N43/653 ,  A01N43/80 ,  C07D233/56 ,  C07D233/60 ,  C07D249/08 ,  C07D405/04 ,  C07D405/06 ,  A01N25/04 ,  A01N25/28

摘要： Provided is an azole derivative superior in disease-controlling activity contained as an active ingredient in agricultural or horticultural chemical agents.The azole derivative according to the present invention is represented by the following General Formula (I): (in Formula (I), R1 represents an unsubstituted or substituted C1-C6-alkyl group; R2 represents a carbonyl group-containing functional group, wherein the carbon atom in the carbonyl group is bound to the carbon atom in the cyclopentane ring substituted with R1 and to a hydrogen atom, a hydroxyl group, R3, OR3, or NR3R4; R3 and R4 each represent a C1-C6-alkyl group, a C2-C6-alkenyl group, or a C2-C6-alkynyl group; Y represents a halogen atom, a C1-C4-alkyl group, a C1-C4-haloalkyl group, a C1-C4-alkoxy group, a C1-C4-haloalkoxy group, a phenyl group, a cyano group, or a nitro group; m is 0 to 5; and A represents a nitrogen atom or a methine group).

公开(公告)号：US09278941B2

公开(公告)日：2016-03-08

申请号：US14359449

申请日：2012-11-16

申请人： Kureha Corporation

发明人： Nobuyuki Araki ,  Taiji Miyake ,  Emiko Obata

IPC分类号： A01N43/653 ,  C07D249/08 ,  A01N43/50

CPC分类号： C07D249/08 ,  A01N43/50 ,  A01N43/653

摘要： In order to provide a compound which exhibits a high controlling effect against plant diseases and is able to reduce phytotoxicity, the present invention is a triazole derivative represented by General Formula (I), the azole derivative being a (−)-enantiomer or (+)-enantiomer having an —R1 group, hydroxy group, and substituted or unsubstituted benzyl group bonded to a cyclopentane ring in cis-form.

摘要翻译： 本发明为通式（I）表示的三唑衍生物，为（ - ） - 对映异构体或（+） - 对映异构体的唑类衍生物，为了提供对植物病害具有高控制效果且能够降低植物毒性的化合物， ） - 对映异构体，其具有-R1基团，羟基和与顺式环戊烷环键合的取代或未取代的苄基。