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1.发明授权Targeting antigens to the MHC class I processing pathway with an anthrax toxin fusion protein 失效将抗原用炭疽毒素融合蛋白靶向MHC I类加工途径公开(公告)号：US06592872B1
公开(公告)日：2003-07-15
申请号：US08937276
申请日：1997-09-15
IPC分类号： A61K3907
CPC分类号： C07K14/005 , A61K39/00 , C07K14/32 , C07K2319/00 , C12N2740/16122 , Y02A50/412 , Y02A50/423 , Y10S514/885 , Y10S530/806 , Y10S530/825
摘要： The present invention provides a vaccine for inducing an immune response in mammal to a specific antigen, where the vaccine comprises a unit dose of a binary, cytotoxic T lymphocyte vaccine comprising an anthrax protective antigen and a full length protein antigen bound to a nontoxic anthrax protective antigen binding protein comprising at least about the first 250 amino acid residues of the lethal factor of Bacillus anthracis and less than all of the amino acid residues of the lethal factor. The present invention also provides a method of immunizing a mammal against an antigen using the vaccine, and a method of inducing antigen-presenting mammalian cells to present specific antigens via the MHC class I processing pathway.
摘要翻译： 本发明提供了用于在哺乳动物中诱导特异性抗原的免疫应答的疫苗，其中疫苗包含单位剂量的二元细胞毒性T淋巴细胞疫苗，其包含炭疽保护性抗原和与无毒性炭疽保护性结合的全长蛋白质抗原 抗原结合蛋白，其包含至少约大约碳芽孢杆菌致死因子的250个氨基酸残基并且小于致死因子的全部氨基酸残基。 本发明还提供了使用该疫苗免疫哺乳动物抗原的方法，以及通过MHC I类加工途径诱导抗原呈递哺乳动物细胞呈递特异性抗原的方法。
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2.发明授权公开(公告)号：US07097965B2
公开(公告)日：2006-08-29
申请号：US10446890
申请日：2003-05-27
CPC分类号： C07K14/005 , A61K39/00 , C07K14/32 , C07K2319/00 , C12N2740/16122 , Y02A50/412 , Y02A50/423 , Y10S514/885 , Y10S530/806 , Y10S530/825
摘要： The present invention provides a vaccine for inducing an immune response in mammal to a specific antigen, where the vaccine comprises a unit dose of a binary toxin protective antigen and the antigen, which is bound to a binary toxin protective antigen binding protein. In one embodiment the vaccine is comprised of an anthrax protective antigen and the antigen bound to anthrax protective antigen binding protein. The present invention also provides a method of immunizing a mammal against an antigen using the vaccine, and a method of inducing antigen-presenting mammalian cells to present specific antigens via the MHC class I processing pathway.
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3.发明授权Peptides containing a fusion joint of a chimeric protein encoded by DNA spanning a tumor-associated chromosomal translocation and their use as immunogens 失效含有由跨越肿瘤相关染色体易位的DNA编码的嵌合蛋白的融合接头的肽及其作为免疫原的用途
公开(公告)号：US5997869A
公开(公告)日：1999-12-07
申请号：US528129
申请日：1995-09-14
IPC分类号： A61K39/00 , A61K39/02 , A61K39/12 , A61K39/21 , A61K39/385 , A61P35/00 , C07K14/47 , C07K14/82 , C12N5/02 , C12N5/08 , A61K38/00 , A61K38/04
CPC分类号： A61K39/02 , A61K39/0011 , A61K39/12 , A61K39/385 , C07K14/4746 , C07K14/82 , A61K2039/5154 , A61K2039/5158 , A61K2039/572 , A61K2039/605 , C12N2740/16134 , C12N2770/24222
摘要： A method of immunizing a mammal against a tumor cell by exposing splenic or peripheral blood mononuclear cells to a peptide that encompasses a fusion joint of a fusion protein encoded by DNA spanning a human chromosomal translocation associated with Ewing's sarcoma (t(11;22)(q24;q12)) or alveolar rhabdomyosarcoma (t(2:13)(q35;q14)) is provided.
摘要翻译： 通过将脾或外周血单核细胞暴露于包含跨越与尤文氏肉瘤相关的人染色体易位的DNA编码的融合蛋白的融合接头的肽（t（11; 22）（ q24; q12））或肺泡横纹肌肉瘤（t（2:13）（q35; q14））。
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4.发明申请Toll Like Receptor 3 Antagonists, Methods and Uses 审中-公开Toll Like Receptor 3 Antagonists，Methods and Uses公开(公告)号：US20120189643A1
公开(公告)日：2012-07-26
申请号：US13412259
申请日：2012-03-05
申请人： Jill M. Carton , Shizhong Chen , Mark Cunningham , Anuk Das , Karen Duffy , Jill M. Giles-Komar , Theresa J. Goletz , David M. Knight , Roberta Lamb , Mouhamadou L. Mbow , Kristen Picha , Gopalan Raghunathan , Lani San Mateo , Robert T. Sarisky , Vedrana Stojanovic-Susulic , Nicole Stowell , Raymond Sweet , Shanrong Zhao
发明人： Jill M. Carton , Shizhong Chen , Mark Cunningham , Anuk Das , Karen Duffy , Jill M. Giles-Komar , Theresa J. Goletz , David M. Knight , Roberta Lamb , Mouhamadou L. Mbow , Kristen Picha , Gopalan Raghunathan , Lani San Mateo , Robert T. Sarisky , Vedrana Stojanovic-Susulic , Nicole Stowell , Raymond Sweet , Shanrong Zhao
IPC分类号： A61K39/395 , C12N15/13 , C12N15/63 , C12N1/21 , A61P3/10 , C12P21/00 , C12N5/16 , A61P29/00 , A61P1/00 , A61P11/00 , C07K16/28 , C12N5/10
CPC分类号： C07K16/2866 , A61K2039/505 , C07K16/2896 , C07K2317/24 , C07K2317/74 , C07K2317/76
摘要： Toll Like Receptor 3 (TLR3) antagonists, polynucleotides encoding TLR3 antagonists or fragments thereof, and methods of making and using the foregoing are disclosed.
摘要翻译： Toll样受体3（TLR3）拮抗剂，编码TLR3拮抗剂或其片段的多核苷酸，以及制备和使用前述物质的方法。
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公开(公告)号：US08153583B2
公开(公告)日：2012-04-10
申请号：US11291140
申请日：2005-11-30
申请人： Jill M. Carton , Shizhong Chen , Mark Cunningham , Anuk Das , Karen Duffy , Jill M. Giles-Komar , Theresa J. Goletz , David M. Knight , Roberta Lamb , Mouhamadou L. Mbow , Kristen Picha , Gopalan Raghunathan , Lani San Mateo , Robert T. Sarisky , Vedrana Stojanovic-Susulic , Nicole Stowell , Raymond Sweet , Shanrong Zhao
发明人： Jill M. Carton , Shizhong Chen , Mark Cunningham , Anuk Das , Karen Duffy , Jill M. Giles-Komar , Theresa J. Goletz , David M. Knight , Roberta Lamb , Mouhamadou L. Mbow , Kristen Picha , Gopalan Raghunathan , Lani San Mateo , Robert T. Sarisky , Vedrana Stojanovic-Susulic , Nicole Stowell , Raymond Sweet , Shanrong Zhao
CPC分类号： C07K16/2896 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92
摘要： Toll Like Receptor 3 (TLR3) antagonists, polynucleotides encoding TLR3 antagonists, and methods of making and using the foregoing are disclosed.
摘要翻译： 公开了Toll样受体3（TLR3）拮抗剂，编码TLR3拮抗剂的多核苷酸，以及制备和使用前述物质的方法。
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