利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

8 条记录 (耗时 0.027 秒)

    Compositions of novel opioid compounds and method of use thereof
    1.
    发明申请
    Compositions of novel opioid compounds and method of use thereof 有权
    新型阿片类化合物的组合物及其使用方法

    公开(公告)号：US20070043028A1

    公开(公告)日：2007-02-22

    申请号：US11404632

    申请日：2006-04-14

    申请人： Shyi-Tai Jan ,  Kwen-Jen Chang ,  Kestutis Biciunas ,  Xin Ma

    发明人： Shyi-Tai Jan ,  Kwen-Jen Chang ,  Kestutis Biciunas ,  Xin Ma

    IPC分类号： A61K31/551 ,  A61K31/497 ,  A61K31/496 ,  A61K31/495 ,  C07D403/02

    CPC分类号： C07D405/12 ,  C07D241/04 ,  C07D401/10 ,  C07D403/10 ,  C07D403/12 ,  C07D403/14 ,  C07D405/06 ,  C07D405/14 ,  C07D491/10

    摘要： Diarylmethylpiperazine compounds are described, which are useful as mu and/or delta receptor opioid compounds, without central side effects. Pharmaceutical compositions containing such compounds are variously useful for peripheral or non-centrally mediated indications, including peripherally mediated and neuropathic pain, urogenital tract disorders, overactive bladder, urinary incontinence, sexual disorders, premature ejaculation, cough, lung edema, cardiac disorders, cardioprotection, gastrointestinal disorders, diarrhea, irritable bowl syndrome, functional distention, immuno-modulation and anti-tumor activity.

    摘要翻译： 描述了二芳基甲基哌嗪化合物，其可用作mu和/或δ受体阿片样物质，没有中枢副作用。 包含这些化合物的药物组合物可用于外周或非中枢介导的适应症，包括周围介导的和神经性疼痛，泌尿生殖道疾病，膀胱过度活动症，尿失禁，性功能障碍，早泄，咳嗽，肺水肿，心脏病，心脏保护， 胃肠道疾病，腹泻，肠易激综合征，功能扩张，免疫调节和抗肿瘤活性。

    Compositions of novel opioid compounds and method of use thereof
    4.
    发明授权
    Compositions of novel opioid compounds and method of use thereof 有权
    新型阿片类化合物的组合物及其使用方法

    公开(公告)号：US07683168B2

    公开(公告)日：2010-03-23

    申请号：US11404632

    申请日：2006-04-14

    申请人： Shyi-Tai Jan ,  Kwen-Jen Chang ,  Kestutis P. Biciunas ,  Xin Ma

    发明人： Shyi-Tai Jan ,  Kwen-Jen Chang ,  Kestutis P. Biciunas ,  Xin Ma

    IPC分类号： C07D245/02

    CPC分类号： C07D405/12 ,  C07D241/04 ,  C07D401/10 ,  C07D403/10 ,  C07D403/12 ,  C07D403/14 ,  C07D405/06 ,  C07D405/14 ,  C07D491/10

    摘要： Diarylmethylpiperazine compounds are described, which are useful as mu and/or delta receptor opioid compounds, without central side effects. Pharmaceutical compositions containing such compounds are variously useful for peripheral or non-centrally mediated indications, including peripherally mediated and neuropathic pain, urogenital tract disorders, overactive bladder, urinary incontinence, sexual disorders, premature ejaculation, cough, lung edema, cardiac disorders, cardioprotection, gastro-intestinal disorders, diarrhea, irritable bowl syndrome, functional distention, immuno-modulation and anti-tumor activity.

    摘要翻译： 描述了二芳基甲基哌嗪化合物，其可用作mu和/或δ受体阿片样物质，没有中枢副作用。 包含这些化合物的药物组合物可用于外周或非中枢介导的适应症，包括周围介导的和神经性疼痛，泌尿生殖道疾病，膀胱过度活动症，尿失禁，性功能障碍，早泄，咳嗽，肺水肿，心脏病，心脏保护， 胃肠道疾病，腹泻，肠易激综合征，功能扩张，免疫调节和抗肿瘤活性。

    One pot synthesis of 5′-hydroxy phosphorylated nucleoside derivatives, and compounds formed thereby
    8.
    发明授权
    One pot synthesis of 5′-hydroxy phosphorylated nucleoside derivatives, and compounds formed thereby 失效
    一锅合成5'-羟基磷酸化核苷衍生物，由此形成化合物

    公开(公告)号：US06465641B1

    公开(公告)日：2002-10-15

    申请号：US09957365

    申请日：2001-09-19

    申请人： Shyi-Tai Jan ,  Fatih M. Uckun

    发明人： Shyi-Tai Jan ,  Fatih M. Uckun

    IPC分类号： C07H1904

    CPC分类号： C07H19/10 ,  C07H19/073

    摘要： A method for the preparation of 5′-hydroxy phosphorylated nucleoside derivatives in a single reaction vessel is provided. The method includes contacting phosphorous oxychloride with a halophenyl moiety followed by contacting the resulting halophenylphosphorodichloridate with a carboxy-protected amino acid and finally contacting the resulting halophenyl carboxy-protected amino acid phosphorochloridate with a nucleoside.

    摘要翻译： 提供了在单个反应容器中制备5'-羟基磷酸化核苷衍生物的方法。 该方法包括使三氯氧化磷与卤代苯基部分接触，接着将所得的卤代苯基二氯代二氯甲烷与羧基保护的氨基酸接触，最后使得到的卤代苯基羧基保护的氨基酸氯代磷酸酯与核苷接触。