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    METHOD OF MANUFACTURING COATING AGENT FOR DRUG RELEASING STENT AND COATING AGENT FOR DRUG RELEASING STENT MANUFACTURED THEREBY
    5.
    发明申请
    METHOD OF MANUFACTURING COATING AGENT FOR DRUG RELEASING STENT AND COATING AGENT FOR DRUG RELEASING STENT MANUFACTURED THEREBY 审中-公开
    制造用于药物释放的涂层剂的方法和用于药物释放的涂层剂

    公开(公告)号：US20120316127A1

    公开(公告)日：2012-12-13

    申请号：US13491145

    申请日：2012-06-07

    申请人： Kyong-Min SHIN ,  Kun Na

    发明人： Kyong-Min SHIN ,  Kun Na

    IPC分类号： A61K31/7068 ,  A61P35/00 ,  B05D5/00

    CPC分类号： A61L31/16 ,  A61L31/10 ,  A61L2300/416 ,  A61L2300/608 ,  A61L2420/02 ,  C08L75/04 ,  C08L27/18

    摘要： This invention relates to a method of manufacturing a coating agent for a drug releasing stent and to a coating agent for a drug releasing stent manufactured thereby. This method includes (1) dissolving polyurethane in tetrahydrofuran, (2) dissolving pluronic F-127 in tetrahydrofuran, (3) dissolving a gemcitabine compound in ethanol, (4) mixing these three solutions obtained in (1) to (3) thus preparing a solution mixture, (5) applying the solution mixture obtained in (4) on a stent coated with a Teflon film, (6) drying the stent of (5) for a predetermined period of time and then immersing the stent in a polyurethane solution in tetrahydrofuran, and (7) removing the stent immersed in (6) from the polyurethane solution and then drying the stent, so that the rate of release of an anti-cancer drug applied on the stent can be continuously and maximally improved thereby maximizing anti-cancer efficacy.

    摘要翻译： 本发明涉及一种制造药物释放支架用涂布剂的方法及其制造的药物释放支架用涂布剂。 该方法包括（1）将聚氨酯溶于四氢呋喃中，（2）将普鲁尼克F-127溶解在四氢呋喃中，（3）将吉西他滨化合物溶于乙醇中，（4）将（1）至（3）中得到的三种溶液混合， 溶液混合物，（5）将（4）中得到的溶液混合物涂布在涂有特氟龙膜的支架上，（6）将（5）的支架干燥规定时间，然后将支架浸渍在聚氨酯溶液 在四氢呋喃中，和（7）从聚氨酯溶液中取出浸没在（6）中的支架，然后干燥支架，使得施加在支架上的抗癌药物的释放速率可以连续和最大程度地提高，从而最大化抗 - 功效

    TEMPERATURE-SENSITIVE CARRIER FOR CARRYING A PHYSIOLOGICALLY ACTIVE SUBSTANCE AND PREPARATION METHOD THEREOF
    6.
    发明申请
    TEMPERATURE-SENSITIVE CARRIER FOR CARRYING A PHYSIOLOGICALLY ACTIVE SUBSTANCE AND PREPARATION METHOD THEREOF 审中-公开
    用于携带生理活性物质的温度敏感载体及其制备方法

    公开(公告)号：US20130095186A1

    公开(公告)日：2013-04-18

    申请号：US13319306

    申请日：2011-06-29

    申请人： Kun Na ,  Young Seok Jung

    发明人： Kun Na ,  Young Seok Jung

    IPC分类号： A61K9/48 ,  A61K38/47

    CPC分类号： A61K9/4816 ,  A61K38/47 ,  A61K41/0028 ,  A61K47/36 ,  A61K47/593 ,  A61K47/61 ,  A61L27/26 ,  A61L27/48 ,  A61L27/54 ,  A61L2300/252 ,  A61L2300/258 ,  A61L2300/62 ,  C08L67/04 ,  C08L5/08

    摘要： The present invention relates to a temperature-sensitive carrier for carrying a physiologically active substance and a preparation method thereof. Specifically, the temperature-sensitive carrier according to the present invention comprises an amphiphilic biodegradable block copolymer containing polysaccharide or polysaccharide and succinic anhydride as a hydrophilic block and polylactide as a non-ionic block. A hydrophilic polymer-polylactide copolymer according to the present invention forms a stable complex with a physiologically active substance such as protein, polynucleotide and the like in vivo via ionic bonding and temperature-sensitive hydrophobic bonding. Therefore, a copolymer according to the present invention can facilitate in vivo delivery of a physiologically active substance and used as an in vivo drug delivery system.

    摘要翻译： 本发明涉及一种携带生理活性物质的感温载体及其制备方法。 具体而言，本发明的感温载体包含含有多糖或多糖的两亲性生物可降解嵌段共聚物和作为亲水性嵌段的琥珀酸酐和作为非离子嵌段的聚交酯。 根据本发明的亲水性聚合物 - 聚丙交酯共聚物通过离子键合和温度敏感性疏水键合在体内与生理活性物质如蛋白质，多核苷酸等形成稳定的复合物。 因此，根据本发明的共聚物可以促进生理活性物质的体内递送并用作体内药物递送系统。

    Tumor environment-induced ligand-expressing nanocarrier system
    7.
    发明授权
    Tumor environment-induced ligand-expressing nanocarrier system 有权

    公开(公告)号：US07371781B2

    公开(公告)日：2008-05-13

    申请号：US10948078

    申请日：2004-09-22

    申请人： You Han Bae ,  Kun Na ,  Eun Seong Lee

    发明人： You Han Bae ,  Kun Na ,  Eun Seong Lee

    IPC分类号： A61K47/00

    CPC分类号： A61K9/1075

    摘要： Drug delivery compositions for specific delivery of a drug to a tumor are described. These compositions include a core for sequestering the drug and a shell to which a ligand is attached for delivery of a drug to target cells. Since normal cells may also be targeted by the ligand, the compositions embed the ligand in the shell until the localized conditions surrounding the tumor cause the ligand to be displayed on the surface of the shell. One composition exhibits shrinkage of the shell at tumor pH, whereas another composition exhibits extension of the ligand at tumor pH. Still another composition causes the ligand to be exhibited at an elevated temperature.

    PH-sensitive polymeric micelles for drug delivery
    8.
    发明申请
    PH-sensitive polymeric micelles for drug delivery 有权
    PH敏感聚合物胶束用于药物递送

    公开(公告)号：US20050070721A1

    公开(公告)日：2005-03-31

    申请号：US10640739

    申请日：2003-05-19

    申请人： You Bae ,  Kun Na ,  Eun Lee

    发明人： You Bae ,  Kun Na ,  Eun Lee

    IPC分类号： A01N43/64 ,  A61K9/00 ,  A61K9/107 ,  A61K9/127 ,  A61K31/41 ,  C07D233/54 ,  C07D233/61 ,  C07D413/06 ,  C08F8/30

    CPC分类号： C07D233/64 ,  A61K9/0019 ,  A61K9/1075 ,  C07D413/06 ,  C08F8/30

    摘要： Mixed micelles containing poly(L-histidine)-poly(ethylene glycol) block copolymer and poly(L-lactic acid)-poly(ethylene glycol) block copolymer are a pH-sensitive drug carrier that release the drug in an acidic microenvironment, but not in the blood. Since the microenvironment of solid tumors is acidic, these mixed micelles are useful for treating cancer, including those cancers exhibiting multidrug resistance. Targeting ligands, such as folate, can also be attached to the mixed micelles for enhancing drug delivery into cells. Methods of making poly(L-histidine), synthetic intermediates, and block copolymers are also described.

    摘要翻译： 含有聚（L-组氨酸） - 聚（乙二醇）嵌段共聚物和聚（L-乳酸） - 聚（乙二醇）嵌段共聚物的混合胶束是在酸性微环境中释放药物的pH敏感药物载体，但是 不在血中 由于实体瘤的微环境是酸性的，所以这些混合胶束可用于治疗癌症，包括那些显示出多药耐药性的癌症。 靶向配体如叶酸也可以连接到混合的胶束上，以增强药物递送到细胞中。 还描述了制备聚（L-组氨酸），合成中间体和嵌段共聚物的方法。

    pH-sensitive polymeric micelles for drug delivery
    9.
    发明授权
    pH-sensitive polymeric micelles for drug delivery 有权
    用于药物递送的pH敏感聚合物胶束

    公开(公告)号：US07229973B2

    公开(公告)日：2007-06-12

    申请号：US10640739

    申请日：2003-05-19

    申请人： You Han Bae ,  Kun Na ,  Eun Seung Lee

    发明人： You Han Bae ,  Kun Na ,  Eun Seung Lee

    IPC分类号： A61K31/704

    CPC分类号： C07D233/64 ,  A61K9/0019 ,  A61K9/1075 ,  C07D413/06 ,  C08F8/30

    摘要： Mixed micelles containing poly(L-histidine)-poly(ethylene glycol) block copolymer and poly(L-lactic acid)-poly(ethylene glycol) block copolymer are a pH-sensitive drug carrier that release the drug in an acidic microenvironment, but not in the blood. Since the microenvironment of solid tumors is acidic, these mixed micelles are useful for treating cancer, including those cancers exhibiting multidrug resistance. Targeting ligands, such as folate, can also be attached to the mixed micelles for enhancing drug delivery into cells. Methods of making poly(L-histidine), synthetic intermediates, and block copolymers are also described.

    摘要翻译： 含有聚（L-组氨酸） - 聚（乙二醇）嵌段共聚物和聚（L-乳酸） - 聚（乙二醇）嵌段共聚物的混合胶束是在酸性微环境中释放药物的pH敏感药物载体，但是 不在血中 由于实体瘤的微环境是酸性的，所以这些混合胶束可用于治疗癌症，包括那些显示出多药耐药性的癌症。 靶向配体如叶酸也可以连接到混合的胶束上，以增强药物递送到细胞中。 还描述了制备聚（L-组氨酸），合成中间体和嵌段共聚物的方法。

    PH-sensitive polymeric micelles for drug delivery
    10.
    发明申请
    PH-sensitive polymeric micelles for drug delivery 失效
    PH敏感聚合物胶束用于药物递送

    公开(公告)号：US20050186263A1

    公开(公告)日：2005-08-25

    申请号：US10846487

    申请日：2004-05-14

    申请人： You Bae ,  Kun Na ,  Eun Lee

    发明人： You Bae ,  Kun Na ,  Eun Lee

    IPC分类号： A01N43/64 ,  A61K9/00 ,  A61K9/107 ,  A61K9/127 ,  A61K31/41 ,  C07D233/54 ,  C07D233/61 ,  C07D413/06 ,  C08F8/30

    CPC分类号： A61K9/1075 ,  A61K9/0019 ,  A61K31/704 ,  C07D233/64 ,  C07D413/06 ,  C08F8/30

    摘要： Mixed micelles containing poly(L-histidine)-poly(ethylene glycol) block copolymer and poly(L-lactic acid)-poly(ethylene glycol) block copolymer are a pH-sensitive drug carrier that release the drug in an acidic microenvironment, but not in the blood. Since the microenvironment of solid tumors is acidic, these mixed micelles are useful for treating cancer, including those cancers exhibiting multidrug resistance. Targeting ligands, such as folate, can also be attached to the mixed micelles for enhancing drug delivery into cells. Methods of treating a warm-blooded animal with such a drug are disclosed.

    摘要翻译： 含有聚（L-组氨酸） - 聚（乙二醇）嵌段共聚物和聚（L-乳酸） - 聚（乙二醇）嵌段共聚物的混合胶束是在酸性微环境中释放药物的pH敏感药物载体，但是 不在血中 由于实体瘤的微环境是酸性的，所以这些混合胶束可用于治疗癌症，包括那些显示出多药耐药性的癌症。 靶向配体如叶酸也可以连接到混合的胶束上，以增强药物递送到细胞中。 公开了用这种药物治疗温血动物的方法。