公开(公告)号：US20230159891A1

公开(公告)日：2023-05-25

申请号：US17915940

申请日：2021-03-30

申请人： Kyoto University ,  TAKEDA PHARMACEUTICAL COMPANY LIMITED

发明人： Shin KANEKO ,  Shoichi IRIGUCHI

IPC分类号： C12N5/0783 ,  A61K35/17

CPC分类号： C12N5/0636 ,  A61K35/17 ,  C12N2506/45 ,  C12N2500/02 ,  C12N2501/155 ,  C12N2501/115 ,  C12N2501/165 ,  C12N2501/2303 ,  C12N2501/2306 ,  C12N2501/2307

摘要： The following are disclosed: a method for producing a T cell progenitor, including step (1) of culturing CD34+ cell in a medium containing an aryl hydrocarbon receptor antagonist, a medium for T cell progenitor differentiation containing an aryl hydrocarbon receptor antagonist, and a T cell progenitor inducer containing an aryl hydrocarbon receptor antagonist.

公开(公告)号：US20220099670A1

公开(公告)日：2022-03-31

申请号：US17427222

申请日：2021-01-31

申请人： Kyoto University ,  TAKEDA PHARMACEUTICAL COMPANY LIMITED

发明人： Shin KANEKO ,  Shoichi IRIGUCHI ,  Keiko SEKIYA ,  Yoshiaki KASSAI

IPC分类号： G01N33/567 ,  C12N5/00 ,  C12N5/0784 ,  G01N33/50

摘要： Disclosed is a method for detecting regulatory dendritic cells, the method comprising step a: detecting the presence or absence of one or more types of molecules on a cell surface in a cell population that comprises regulatory dendritic cells; and step b: identifying regulatory dendritic cells on the basis of the presence or absence of the one or more types of molecules. Also disclosed is a method for producing a cell population enriched for regulatory dendritic cells, the method comprising step 1: detecting the presence or absence of one or more types of molecules on a cell surface in a cell population that comprises regulatory dendritic cells; and step 2: obtaining a cell population enriched for regulatory dendritic cells on the basis of the presence or absence of the one or more types of molecules. Further disclosed is a cell population enriched for regulatory dendritic cells obtained by the method.

公开(公告)号：US20190330596A1

公开(公告)日：2019-10-31

申请号：US16312789

申请日：2017-06-21

申请人： KYOTO UNIVERSITY

发明人： Shin KANEKO ,  Yutaka YASUI ,  Shoichi IRIGUCHI ,  Tatsuki UEDA

IPC分类号： C12N5/074 ,  C12N5/10 ,  C12N15/85 ,  C12N5/0783 ,  C07K14/725 ,  C07D401/04

摘要： A method for producing CD4/CD8 double-positive T cells, comprising the steps of: (1) culturing pluripotent stem cells in a medium to induce hematopoietic progenitor cells; and (2) culturing the hematopoietic progenitor cells obtained in the step (1) in a medium containing a p38 inhibitor and/or SDF-1 to induce CD4/CD8 double-positive T cells.