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    METHOD FOR PRODUCING T CELLS
    3.
    发明申请
    METHOD FOR PRODUCING T CELLS 有权

    公开(公告)号：US20220411752A1

    公开(公告)日：2022-12-29

    申请号：US17773467

    申请日：2020-10-30

    Applicant: Kyoto University ,  Takeda Pharmaceutical Company Limited

    Inventor： Shin KANEKO ,  Hisashi YANO ,  Tokuyuki SHINOHARA

    IPC: C12N5/0783 ,  C12N15/90

    Abstract: Provided is an excellent method for producing an IL-4 non-secreting and IFN-γ secreting (Th1-type) or IFN-γ non-secreting and IL-4 secreting (Th2-type) CD4 single-positive T cell (CD4SP T cell). The method for producing the Th1-type or Th2-type CD4SP T cell of the present invention comprises a step of inducing a CD4 single-positive T cell from a hematopoietic stem cell (HSC) and/or a hematopoietic progenitor cell (HPC) substantially defective in a factor involved in IL-4 secretion or a factor involved in IFN-γ secretion.

    METHOD FOR DETECTING CELLS
    4.
    发明申请
    METHOD FOR DETECTING CELLS 有权

    公开(公告)号：US20220099670A1

    公开(公告)日：2022-03-31

    申请号：US17427222

    申请日：2021-01-31

    Applicant: Kyoto University ,  TAKEDA PHARMACEUTICAL COMPANY LIMITED

    Inventor： Shin KANEKO ,  Shoichi IRIGUCHI ,  Keiko SEKIYA ,  Yoshiaki KASSAI

    IPC: G01N33/567 ,  C12N5/00 ,  C12N5/0784 ,  G01N33/50

    Abstract: Disclosed is a method for detecting regulatory dendritic cells, the method comprising step a: detecting the presence or absence of one or more types of molecules on a cell surface in a cell population that comprises regulatory dendritic cells; and step b: identifying regulatory dendritic cells on the basis of the presence or absence of the one or more types of molecules. Also disclosed is a method for producing a cell population enriched for regulatory dendritic cells, the method comprising step 1: detecting the presence or absence of one or more types of molecules on a cell surface in a cell population that comprises regulatory dendritic cells; and step 2: obtaining a cell population enriched for regulatory dendritic cells on the basis of the presence or absence of the one or more types of molecules. Further disclosed is a cell population enriched for regulatory dendritic cells obtained by the method.

    T-CELL RECEPTOR MODIFIED OBJECT
    6.
    发明申请
    T-CELL RECEPTOR MODIFIED OBJECT 有权

    公开(公告)号：US20220089672A1

    公开(公告)日：2022-03-24

    申请号：US17416859

    申请日：2019-12-26

    Applicant: Kyoto University ,  Takeda Pharmaceutical Company Limited

    Inventor： Shin KANEKO ,  Yoshiaki KASSAI ,  Akira HAYASHI

    IPC: C07K14/725 ,  C12N15/86

    Abstract: The present invention provides a variant of a T-cell receptor containing a combination of two polypeptides containing a constant region of a T cell receptor chain selected from the group consisting of α chain, β chain, γ chain and δ chain, wherein the polypeptide does not contain a complementarity determining region (CDR) of the T cell receptor chain, a complementarity determining region (CDR) of the α chain, and a complementarity determining region (CDR) of the β chain.

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