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    USE OF PARTICULATE CONTRAST AGENTS IN DIAGNOSTIC IMAGING FOR STUDYING PHYSIOLOGICAL PARAMATERS
    3.
    发明申请
    USE OF PARTICULATE CONTRAST AGENTS IN DIAGNOSTIC IMAGING FOR STUDYING PHYSIOLOGICAL PARAMATERS 审中-公开
    用于研究生理参数的诊断成像中的粒子对比剂

    公开(公告)号：US20090191131A1

    公开(公告)日：2009-07-30

    申请号：US12354275

    申请日：2009-01-15

    申请人： Sigrid Lise Fossheim ,  Jo Klaveness ,  Atle Bjornerud ,  Pal Rongved ,  Klaes Golman ,  Roald Skurtveit

    发明人： Sigrid Lise Fossheim ,  Jo Klaveness ,  Atle Bjornerud ,  Pal Rongved ,  Klaes Golman ,  Roald Skurtveit

    IPC分类号： A61K49/18 ,  A61K49/12

    CPC分类号： A61B5/01 ,  A61B5/055 ,  A61B5/416 ,  A61B5/4519 ,  A61B8/481 ,  A61K49/1812 ,  A61K49/223

    摘要： The present invention relates to a method of imaging of an animate human or non-human animal body, which method comprises: administering parenterally to said body a particulate material comprising a matrix or membrane material and at least one contrast generating species, which matrix or membrane material is responsive to a pre-selected physiological parameter whereby to alter the contrast efficacy of said species in response to a change in the value of said parameter; generating image data of at least part of said body in which said species is present; and generating therefrom a signal indicative of the value or variation of said parameter in said part of said body. The invention also relates to contrast media for imaging a physiological parameter.

    摘要翻译： 本发明涉及一种对人或非动物体动物进行成像的方法，该方法包括：向所述身体肠胃外给予包含基质或膜材料和至少一种对比生成物质的颗粒材料，所述物质或基质或膜 材料响应于预先选择的生理参数，从而响应于所述参数的值的变化来改变所述物种的对比效能; 生成存在所述物种的所述身体的至少一部分的图像数据; 以及由此生成指示所述身体的所述部分中的所述参数的值或变化的信号。 本发明还涉及用于对生理参数进行成像的造影剂。

    Tumor grading from blood volume maps
    4.
    发明申请
    Tumor grading from blood volume maps 有权
    肿瘤分级从血容量图

    公开(公告)号：US20080221441A1

    公开(公告)日：2008-09-11

    申请号：US11715529

    申请日：2007-03-08

    申请人： Atle Bjornerud ,  Kyrre Eeg Emblem

    发明人： Atle Bjornerud ,  Kyrre Eeg Emblem

    IPC分类号： A61B6/03

    CPC分类号： G06T7/0012 ,  A61B6/501 ,  A61B6/507 ,  G06T7/11 ,  G06T2207/10072 ,  G06T2207/30016 ,  G06T2207/30096

    摘要： An embodiment of the invention is to make possible a non-invasive grading of a tumor based on parameters determined from a frequency distribution (histogram) of values in a map representing cerebral blood volume (CBV) or cellular metabolism in the tumour. The method is especially applicable to brain tumors such as gliomas where histological grading is difficult. The invention provides a precise and consistent grading since it relies on values selected from the whole tumor (not just from hot spots); since it takes the diversity or heterogeneity of the vascularization into account by analyzing the frequency distribution (not just a mean value); and since it involves and allows for a more automated procedure wherein any subjective contributions from human operators is not critical to the resulting grading. CBV maps may be obtained by perfusion imaging using MRI or CT scanning. Cellular metabolism maps may be obtained from a glucose metabolism map obtained by positron emission tomography (PET).

    摘要翻译： 本发明的一个实施方案是基于根据表示肿瘤中的脑血容量（CBV）或细胞代谢的图中的值的频率分布（直方图）确定的参数，使肿瘤的非侵入性分级成为可能。 该方法特别适用于组织学分级困难的脑瘤如胶质瘤。 本发明提供精确和一致的分级，因为它依赖于从整个肿瘤中选择的值（不仅来自热点）; 因为通过分析频率分布（不仅仅是平均值）来考虑血管形成的多样性或异质性; 并且因为它涉及并允许更自动化的过程，其中来自人类操作者的任何主观贡献对于最终的分级不是关键的。 可以通过使用MRI或CT扫描的灌注成像获得CBV图。 可以从通过正电子发射断层摄影（PET）获得的葡萄糖代谢图获得细胞代谢图。