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    Neurobiological method for measuring human intelligence and system for the same
    9.
    发明授权
    Neurobiological method for measuring human intelligence and system for the same 有权
    用于测量人体智力和系统的神经生物学方法

    公开(公告)号：US08301223B2

    公开(公告)日：2012-10-30

    申请号：US12376799

    申请日：2007-08-09

    申请人： Kun Ho Lee ,  Yu Yong Choi ,  Kyung Jin Kim ,  Jong Min Lee

    发明人： Kun Ho Lee ,  Yu Yong Choi ,  Kyung Jin Kim ,  Jong Min Lee

    IPC分类号： A61B5/05

    CPC分类号： A61B5/16 ,  G01R33/4806 ,  G06F19/00

    摘要： A method for measuring human intelligence using a neurobiogical model is provided. The method enables neurometric IQ to be measured by processing MRI and fMRI images of a subject to determine cortical thicknesses and brain activation level, determining structural IQ (sIQ) and functional IQ (fIQ) from the determined cortical thicknesses and brain activation level, and using the structural IQ (sIQ) and the functional IQ (fIQ) as predictors to measure the neurometric IQ of the subject. With this, individual differences in general cognitive ability can be easily assessed. It suggests that general cognitive ability can be explained by two different neural bases or traits: facilitation of neural circuits and accumulation of crystallized knowledge.

    摘要翻译： 提供了一种使用神经生物学模型测量人类智力的方法。 该方法通过处理受试者的MRI和fMRI图像来测量神经测量IQ，以确定皮层厚度和脑激活水平，从确定的皮层厚度和脑激活水平确定结构性IQ（sIQ）和功能IQ（fIQ），并使用 结构性IQ（sIQ）和功能IQ（fIQ）作为测量受试者的神经测量IQ的预测因子。 因此，可以容易地评估个体差异的一般认知能力。 这表明一般认知能力可以通过两种不同的神经基础或特征来解释：促进神经回路和结晶化知识的积累。

    METHODS OF TREATING DISEASES WITH ANTI-VEGF ANTIBODIES
    10.
    发明申请
    METHODS OF TREATING DISEASES WITH ANTI-VEGF ANTIBODIES 审中-公开
    用抗VEGF抗体治疗疾病的方法

    公开(公告)号：US20100330096A1

    公开(公告)日：2010-12-30

    申请号：US12876800

    申请日：2010-09-07

    申请人： Kyung Jin Kim

    发明人： Kyung Jin Kim

    IPC分类号： A61K39/395 ,  A61P9/00

    CPC分类号： C07K16/22 ,  A61K38/00 ,  A61K47/6425 ,  A61K47/6811 ,  A61K47/6843 ,  A61K2039/505 ,  C07K14/52 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/30

    摘要： The present invention provides monoclonal antibodies, and portions thereof, which are capable of specifically binding to human vascular endothelial cell growth factor (hVEGF) or hVEGF-related protein. The invention also provides hybridoma cell lines that produce such monoclonal antibodies. The monoclonal antibodies of the invention are useful as therapeutic agents either by themselves or in conjunction with cytotoxic or other chemotherapeutic agents, to treat diseases that are characterized by excessive vascular endothelial cell proliferation. The monoclonal antibodies of the invention also are useful in diagnostic and analytical methods for determining the presence of hVEGF or hVEGF related-protein in a test sample.

    摘要翻译： 本发明提供能够特异性结合人血管内皮细胞生长因子（hVEGF）或hVEGF相关蛋白的单克隆抗体及其部分。 本发明还提供了产生这种单克隆抗体的杂交瘤细胞系。 本发明的单克隆抗体本身或与细胞毒性或其它化学治疗剂联用可用作治疗剂，以治疗以过量血管内皮细胞增殖为特征的疾病。 本发明的单克隆抗体也可用于测定样品中hVEGF或hVEGF相关蛋白的存在的诊断和分析方法。