公开(公告)号：US20250134794A1

公开(公告)日：2025-05-01

申请号：US18932836

申请日：2024-10-31

Applicant: L'OREAL

Inventor： Rebecca BARRESI ,  I-chien LIAO ,  Charbel BOUEZ

IPC: A61K8/64 ,  A61K9/00 ,  A61K38/08 ,  A61Q19/02

Abstract: Bioactive walnut peptides and use of the bioactive walnut peptides for topical application to the skin are described. The bioactive walnut peptides, which may be incorporated into a pharmaceutical or cosmetic compositions, are useful for treating, preventing, and improving damage to skin and combating or preventing physiological changes associated with skin aging.

公开(公告)号：US20230190608A1

公开(公告)日：2023-06-22

申请号：US18087192

申请日：2022-12-22

Applicant: L'Oreal

Inventor： I-Chien LIAO ,  Charbel BOUEZ ,  Ying CHEN ,  Qian ZHENG ,  Julien LABOUREAU ,  Ronni Lynn WEINKAUF

IPC: A61K8/44 ,  A61K8/67 ,  A61K8/365 ,  A61Q19/08

CPC classification number: A61K8/44 ,  A61K8/671 ,  A61K8/365 ,  A61Q19/08

Abstract: The disclosure relates to compositions, methods, and kits for improving the appearance of the skin by applying acetyl trifluoromethylphenyl valylglycine, at least one retinoid, and optionally at least one additional skin peeling agent to the skin.

公开(公告)号：US20230133445A1

公开(公告)日：2023-05-04

申请号：US17976631

申请日：2022-10-28

Applicant: L'Oreal

Inventor： I-Chien LIAO ,  Rebecca BARRESI ,  Charbel BOUEZ ,  Qian ZHENG ,  Patricia BRIEVA ,  Stephen Matthew LYNCH

IPC: A61K8/42 ,  A61K8/365

Abstract: The disclosure relates to compositions, methods, regimens, and kits for improving the appearance of the skin by applying acetyl trifluoromethylphenyl valylglycine and at least one peeling agent to the skin.

公开(公告)号：US20210270813A1

公开(公告)日：2021-09-02

申请号：US17255614

申请日：2018-06-28

Applicant: L'OREAL

Inventor： Rodrigo DE VECCHI ,  Lionel BRETON ,  Charbel BOUEZ ,  Vanja DAKIC

IPC: G01N33/50 ,  C12N5/00 ,  C12N5/0793 ,  C12N5/071

Abstract: The present invention relates to a kit comprising a co-culture microdevice containing peripheral sensory neurons (PSN) and human epidermal keratinocytes (HEK) in a cell culture adapted for both cell types. It is also described a method for screening an active compound using the kit according to the present invention, as well as the use thereof for in vitro dmg tests and for producing a cosmetic product for various dermatological applications, such as atopic dermatitis, sensitive skin, photoaging, wound healing and epidermal thickness in aged skin.