公开(公告)号：US09611229B2

公开(公告)日：2017-04-04

申请号：US14759280

申请日：2014-01-07

Applicant: LABORATORIOS DEL DR. ESTEVE S.A.

Inventor： Antoni Torrens-Jover ,  Ute Christmann ,  Josè-Luis Diaz-Fernández ,  Carmen Almansa-Rosales

IPC: C07D249/04 ,  C07D249/06 ,  C07D295/185 ,  C07F7/10 ,  C07D401/12

CPC classification number: C07D249/04 ,  C07D249/06 ,  C07D295/185 ,  C07D401/12 ,  C07F7/10

Abstract: The present invention relates to new 1,2,3-triazole-amine derivatives, having affinity for sigma receptors, especially sigma-1 receptor, as well as to the process for the preparation thereof, to compositions comprising them, and to their use as medicaments for the treatment of sigma receptor related diseases and disorders.

公开(公告)号：US10071968B2

公开(公告)日：2018-09-11

申请号：US15531810

申请日：2015-12-15

Applicant: LABORATORIOS DEL DR. ESTEVE S.A.

Inventor： Antoni Torrens-Jover ,  Josep Mas-Prio ,  Carmen Almansa-Rosales ,  Monica Garcia-Lopez

IPC: C07D231/12 ,  C07D401/06 ,  C07D409/06 ,  C07D417/06 ,  C07D401/12

CPC classification number: C07D231/12 ,  C07D401/12 ,  C07D409/06 ,  C07D417/06

Abstract: The present invention relates to compounds having dual pharmacological activity towards both the sigma (σ) receptor, and the μ-opiod receptor and more particularly to methyl-1H-pyrazole alkylamine compounds having this pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.

公开(公告)号：US09464069B2

公开(公告)日：2016-10-11

申请号：US14907899

申请日：2014-07-29

Applicant: LABORATORIOS DEL DR. ESTEVE S.A.

Inventor： Antoni Torrens-Jover ,  Rosa Ortuño-Mingarro ,  Àlex Pericas-Cano ,  Èric Ferrer-Mallofrè

IPC: C07C211/17 ,  C07D401/12 ,  C07D207/06 ,  C07D295/03 ,  C07D211/14 ,  C07D231/22

CPC classification number: C07D401/12 ,  C07C211/17 ,  C07C217/44 ,  C07C2601/04 ,  C07D207/06 ,  C07D211/14 ,  C07D231/22 ,  C07D295/03 ,  C07D295/096

Abstract: The invention refers to compounds of general formula (I) wherein the variables take various meanings, pharmaceutical compositions containing them and their use in medicine, particularly in pain therapy.

公开(公告)号：US20180251430A1

公开(公告)日：2018-09-06

申请号：US15757177

申请日：2016-09-01

Applicant: LABORATORIOS DEL DR. ESTEVE, S.A.

Inventor： Antoni Torrens-Jover ,  Carmen Almansa Rosales

IPC: C07D231/12

CPC classification number: C07D231/12 ,  C07B2200/13 ,  C07D403/12

Abstract: The present invention relates to 1-(4-(2-((1-(3,4-difluorophenyl)-1 H-pyrazol-3-yl)methoxy)ethyl)piperazin-1-yl)ethanone salts, specifically to the hydrochloride and to the maleate, to pharmaceutical compositions comprising them, and to their use in therapy and/or prophylaxis of sigma receptor associated diseases.