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公开(公告)号：US20200248165A1
公开(公告)日：2020-08-06
申请号：US16785232
申请日：2020-02-07
Applicant: Lallemand Hungary Liquidity Management LLC
Inventor： Allan Froehlich , Brooks Henningsen
Abstract: There is provided chimeric polypeptides capable of converting xylose to xylulose, engineered host cells that express the chimeric polypeptides, methods of creating chimeric polypeptides, and methods of fermenting cellulosic biomass to produce biofuels, including ethanol.
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公开(公告)号：US20190106464A1
公开(公告)日：2019-04-11
申请号：US16085959
申请日：2017-03-17
Applicant: Lallemand Hungary Liquidity Management LLC
Inventor： Michelle Oeser , Brooks Henningsen , Janet Fisher , Charles F. Rice , Allan Froehlich , Aaron Argyros , Rintze M. Zelle
IPC: C07K14/395 , C12N15/52 , C12N1/22 , C12N15/113 , C12P7/06 , C12N15/81
Abstract: The present disclosure relates to the modulation in the RAS/cAMP/PKA signaling pathway for maintaining the propagation efficiency and increasing fermentation efficiency of yeast cells. The present disclosure provides yeast cells having or engineered to exhibit a modulation in signaling in a RAS/cAMP/PKA pathway, depending on conditions. For example the yeast cells can be selected or genetically modified to express a mutated Ras1 protein, a mutated Ras2 protein, a mutated Ira1 protein and/or a mutated Ira2 protein, optionally in combination with specific promoters. Also provided herewith are methods for propagating the yeast cells as well as using the yeast cells to generate a fermented product (such as ethanol).
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公开(公告)号：US11999987B2
公开(公告)日：2024-06-04
申请号：US17206943
申请日：2021-03-19
Applicant: Lallemand Hungary Liquidity Management LLC
Inventor： James L. Steele , Brooks Henningsen , Jeffery R. Broadbent , Ekkarat Phrommao , Fernanda Cristina Firmino
IPC: C12P39/00 , C07K14/335 , C12N1/20 , C12P7/06
CPC classification number: C12P39/00 , C07K14/335 , C12N1/20 , C12P7/06 , C12Y101/01001 , C12Y401/01001
Abstract: The present disclosure concerns a co-culture of bacterial cells for making a fermented product from a biomass. The co-culture comprising a first recombinant lactic acid bacteria (LAB) cell expressing at least one bacteriocin and a second recombinant lactic acid bacteria (LAB) cell capable of converting, at least in part, the biomass into the fermented product. The second recombinant LAB cell is immune to the bacteriocin produced by the first recombinant LAB cell. The co-culture can be used, optionally in combination with a yeast host cell, to make a fermented product. The present disclosure also provides processes for making the fermented product by using the co-culture as wells kits and media comprising the co-culture.
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公开(公告)号：US20220007683A1
公开(公告)日：2022-01-13
申请号：US17372332
申请日：2021-07-09
Applicant: Lallemand Hungary Liquidity Management LLC
Inventor： James L. Steele , Brooks Henningsen , Jeffery R. Broadbent , Ekkarat Phrommao , Fernanda Cristina Firmino
IPC: A23K10/38 , A23K10/18 , A23K10/12 , A23K20/147 , C12N1/18
Abstract: Fermentation by-products can be used in feed to provide nutrients to animals. The present disclosure concerns a process for modulating the nutritional content in a whole stillage. The process includes fermenting a biomass in the presence of a recombinant lactic acid bacteria (LAB) cell and a yeast with a biomass and recuperating the whole stillage once the fermentation has been completed. The recombinant LAB is capable of expressing one or more first heterologous enzyme for converting the biomass into the fermentation product.
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公开(公告)号：US20210155944A1
公开(公告)日：2021-05-27
申请号：US16648625
申请日：2018-09-18
Applicant: Lallemand Hungary Liquidity Management LLC
Inventor： Brooks Henningsen , Sean Covalla , Rintze Zelle , Allan Froehlich
IPC: C12N15/81 , C12N9/92 , C12N9/12 , C12N9/90 , C12N9/10 , C12N9/04 , C07K14/395 , C12N9/00 , C12P7/06
Abstract: Acetate is a potent microbial inhibitor which can affect the performance of yeast in ethanolic fermentation. The present disclosure provides a recombinant microbial host cell having (i) a first genetic modification for increasing the activity of one or more proteins that function in a first metabolic pathway to convert acetate into an alcohol in the microbial host cell; (ii) a second genetic modification for increasing the activity of one or more proteins that function in a second metabolic pathway to import glycerol in the recombinant microbial host cell (iii) a third genetic modification for increasing the activity of one or more proteins that function in a third metabolic pathway to convert a C5 carbohydrate into ethanol in the microbial host cell. The recombinant microbial host cell comprises and natively expresses native proteins that function in a fourth native metabolic pathway to produce glycerol in the microbial host cell.
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Patent Agency Ranking
公开(公告)号：US20200087672A1
公开(公告)日：2020-03-19
申请号：US16493245
申请日：2018-03-13
Applicant: Lallemand Hungary Liquidity Management LLC
Inventor： Aaron Argyros , Michelle Oeser , Erin Wiswall , Janet Fisher , Johannes Van Eijk , J. Kevin Kraus , Kevin Wenger , Brooks Henningsen , Ryan Skinner
IPC: C12N15/81 , A21D8/04 , A23K10/18 , A23K20/189 , A23L33/14 , C12N1/18 , C12N9/16 , C12N9/30 , C12N9/34
Abstract: The present disclosure concerns recombinant yeast host cells expressing cell-associated heterologous food and/or feed enzymes which are expressed during the propagation phase of the recombinant yeast hosts cells. The recombinant yeast host cells can be used in a subsequent production process to make food and/or feed products, for example, baked products.
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7.发明申请公开(公告)号：US20160040152A1
公开(公告)日：2016-02-11
申请号：US14820695
申请日：2015-08-07
Applicant: LALLEMAND HUNGARY LIQUIDITY MANAGEMENT LLC
Inventor： Allan Froehlich , Brooks Henningsen
Abstract: There is provided chimeric polypeptides capable of converting xylose to xylulose, engineered host cells that express the chimeric polypeptides, methods of creating chimeric polypeptides, and methods of fermenting cellulosic biomass to produce biofuels, including ethanol.
Abstract translation: 提供了能够将木糖转化为木酮糖的嵌合多肽，表达嵌合多肽的工程化宿主细胞，产生嵌合多肽的方法，以及发酵纤维素生物质生产生物燃料（包括乙醇）的方法。
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公开(公告)号：US11667680B2
公开(公告)日：2023-06-06
申请号：US16085959
申请日：2017-03-17
Applicant: Lallemand Hungary Liquidity Management LLC
Inventor： Michelle Oeser , Brooks Henningsen , Janet Fisher , Charles F. Rice , Allan Froehlich , Aaron Argyros , Rintze M. Zelle
IPC: C07K14/395 , C12N1/22 , C12P7/06 , C12N15/113 , C12N15/52 , C12N15/81
CPC classification number: C07K14/395 , C12N1/22 , C12N15/113 , C12N15/52 , C12N15/815 , C12P7/06 , C12P7/065 , Y02E50/10
Abstract: The present disclosure relates to the modulation in the RAS/cAMP/PKA signaling pathway for maintaining the propagation efficiency and increasing fermentation efficiency of yeast cells. The present disclosure provides yeast cells having or engineered to exhibit a modulation in signaling in a RAS/cAMP/PKA pathway, depending on conditions. For example the yeast cells can be selected or genetically modified to express a mutated Ras1 protein, a mutated Ras2 protein, a mutated Ira1 protein and/or a mutated Ira2 protein, optionally in combination with specific promoters. Also provided herewith are methods for propagating the yeast cells as well as using the yeast cells to generate a fermented product (such as ethanol).
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公开(公告)号：US20220010340A1
公开(公告)日：2022-01-13
申请号：US17372291
申请日：2021-07-09
Applicant: Lallemand Hungary Liquidity Management LLC
Inventor： James L. Steele , Brooks Henningsen , Jeffery R. Broadbent , Ekkarat Phrommao , Fernanda Cristina Firmino
Abstract: The present disclosure concerns a recombinant bacterial host cell capable of providing a nitrogen source to a yeast during fermentation to make ethanol. The recombinant bacterial host cell is capable of converting a biomass into ethanol. The recombinant bacterial host cell has at least one first genetic modification. The at least one genetic modifications confers to the recombinant bacterial host cell the ability to increase, when compared to a corresponding control bacterial cell lacking the at least one first genetic modification, the proteolytic activity associated with the recombinant bacterial host cell. The at least one genetic modification also confers the recombinant bacterial host cell the ability to provide a nitrogen source to a yeast capable of converting the biomass into ethanol, wherein the nitrogen source comprises a peptide, an amino acid and/or ammonia.
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公开(公告)号：US20180251750A1
公开(公告)日：2018-09-06
申请号：US15884449
申请日：2018-01-31
Applicant: LALLEMAND HUNGARY LIQUIDITY MANAGEMENT LLC
Inventor： Allan Froehlich , Brooks Henningsen , Sean Covalla , Rintze M. Zelle
IPC: C12N9/92 , C07K14/395 , C12P7/06
CPC classification number: C12N9/92 , C07K14/395 , C12P7/06 , C12Y503/01005 , Y02E50/17
Abstract: There is provided an engineered host cells comprising (a) one or more mutations in one or more endogenous genes encoding a protein associated with iron metabolism; and (b) at least one gene encoding a polypeptide having xylose isomerase activity, and methods of their use thereof.
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