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1.发明公开公开(公告)号：US20240207186A1
公开(公告)日：2024-06-27
申请号：US18422810
申请日：2024-01-25
发明人： Kurt I. KAMRUD , Nathaniel S. WANG , Martina FELDERMAN , Bolyn HUBBY , Heather D, GOUVIS , Nicholas O. FISCHER , Matthew A. COLEMAN , Angela Clare EVANS , Wei HE , Amy RASLEY , Craig D. BLANCHETTE
CPC分类号： A61K9/1272 , A61K9/1274 , A61K47/6917 , C12N15/88 , A61K48/0008
摘要： Nanolipoprotein particles comprising at least a scaffold protein component and a membrane lipid component and related complexes, compositions, methods and systems are described, in which the membrane lipid component comprises at least one or more membrane forming lipids and one or more cationic lipids.
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公开(公告)号：US20200046848A1
公开(公告)日：2020-02-13
申请号：US16609420
申请日：2018-05-01
摘要： A telodendrimer-nanolipoprotein particle (t-NLP), comprising one or more membrane forming lipids, one or more telodendrimers, and a scaffold protein and a Chlamydia major outer membrane protein (MOMP) comprising a MOMP hydrophobic region, and related compositions methods and systems.
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公开(公告)号：US20210317234A1
公开(公告)日：2021-10-14
申请号：US17308921
申请日：2021-05-05
发明人： Juntao LUO , Wei HE , Kit S. LAM , Paul HENDERSON , Matthew A. COLEMAN
IPC分类号： C07K17/02 , C07K14/775
摘要： The present invention provides a nanodisc with a membrane scaffold protein. The nanodisc includes a membrane scaffold protein, a telodendrimer and a lipid. The membrane scaffold protein can be apolipoprotein. The telodendrimer has the general formula PEG-L-D-(R)n, wherein D is a dendritic polymer; L is a bond or a linker linked to the focal point group of the dendritic polymer; each PEG is a poly(ethylene glycol) polymer, each R is and end group of the dendritic polymer, or and end group with a covalently bound hydrophobic group, hydrophilic group, amphiphilic compound, or drug; and subscript n is an integer from 2 to 20. Cell free methods of making the nanodiscs are also provided.
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4.发明申请公开(公告)号：US20140369990A1
公开(公告)日：2014-12-18
申请号：US14457035
申请日：2014-08-11
摘要： Targeted antimicrobials are described and related, compositions, methods and systems.
摘要翻译： 有针对性的抗微生物剂被描述和相关，组合物，方法和系统。
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公开(公告)号：US20220283171A1
公开(公告)日：2022-09-08
申请号：US17700145
申请日：2022-03-21
IPC分类号： G01N33/58 , C07K14/705 , C12P21/02 , G01N33/543
摘要： Provided herein are methods and systems for the production of a nanolipoprotein particle (NLP) that includes a scaffold protein a membrane forming lipid and optionally a target protein. At least one of the scaffold protein and target protein can be provided through an IVT system. The membrane forming lipid, scaffold protein and optionally the target protein can be assembled for a time and under conditions that allow obtaining high yield NLPs, NPLs with an increased solubility, an NLP of a controlled size, and/or an NLP having a size predetermined to include a pre-selected target protein.
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公开(公告)号：US20190094230A1
公开(公告)日：2019-03-28
申请号：US16159189
申请日：2018-10-12
IPC分类号： G01N33/58 , C07K14/705 , G01N33/543 , C12P21/02
摘要： Provided herein are methods and systems for the production of a nanolipoprotein particle (NLP) that includes a scaffold protein a membrane forming lipid and optionally a target protein. At least one of the scaffold protein and target protein can be provided through an IVT system. The membrane forming lipid, scaffold protein and optionally the target protein can be assembled for a time and under conditions that allow obtaining high yield NLPs, NPLs with an increased solubility, an NLP of a controlled size, and/or an NLP having a size predetermined to include a pre-selected target protein.
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公开(公告)号：US20230416414A1
公开(公告)日：2023-12-28
申请号：US18334034
申请日：2023-06-13
发明人： Juntao LUO , Wei HE , Kit S. LAM , Paul HENDERSON , Matthew A. COLEMAN
IPC分类号： C07K17/02 , C07K14/775
CPC分类号： C07K17/02 , C07K14/775
摘要： The present invention provides a nanodisc with a membrane scaffold protein. The nanodisc includes a membrane scaffold protein, a telodendrimer and a lipid. The membrane scaffold protein can be apolipoprotein. The telodendrimer has the general formula PEG-L-D-(R)n, wherein D is a dendritic polymer; L is a bond or a linker linked to the focal point group of the dendritic polymer; each PEG is a poly(ethylene glycol) polymer; each R is and end group of the dendritic polymer, or and end group with a covalently bound hydrophobic group, hydrophilic group, amphiphilic compound, or drug; and subscript n is an integer from 2 to 20. Cell free methods of making the nanodiscs are also provided.
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公开(公告)号：US20220211866A1
公开(公告)日：2022-07-07
申请号：US17561625
申请日：2021-12-23
摘要： A telodendrimer-nanolipoprotein particle (t-NLP), comprising one or more membrane forming lipids, one or more telodendrimers, and a scaffold protein and a Chlamydia major outer membrane protein (MOMP) comprising a MOMP hydrophobic region, and related compositions methods and systems.
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公开(公告)号：US20180079829A1
公开(公告)日：2018-03-22
申请号：US15499855
申请日：2017-04-27
发明人： Juntao LUO , Wei HE , Kit S. LAM , Paul HENDERSON , Matthew A. COLEMAN
IPC分类号： C07K17/02 , C07K14/775
CPC分类号： C07K17/02 , C07K14/775
摘要： The present invention provides a nanodisc with a membrane scaffold protein. The nanodisc includes a membrane scaffold protein, a telodendrimer and a lipid. The membrane scaffold protein can be apolipoprotein. The telodendrimer has the general formula PEG-L-D-(R)n, wherein D is a dendritic polymer; L is a bond or a linker linked to the focal point group of the dendritic polymer; each PEG is a polyethylene glycol) polymer; each R is and end group of the dendritic polymer, or and end group with a covalently bound hydrophobic group, hydrophilic group, amphiphilic compound, or drug; and subscript n is an integer from 2 to 20. Cell free methods of making the nanodiscs are also provided.
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10.发明申请METHODS AND SYSTEMS FOR ENGINEERING BACTERIAL SYSTEMS TO SHIELD TOXICITY DURING NON-NATIVE PROTEIN EXPRESSION AND PURIFICATION 审中-公开工程细菌系统对非蛋白质表达和纯化期间的屏蔽毒性的方法和系统公开(公告)号：US20160362697A1
公开(公告)日：2016-12-15
申请号：US15178454
申请日：2016-06-09
IPC分类号： C12N15/70 , C12N9/88 , C12N7/00 , C12N9/02 , C07K14/245 , C07K14/005
CPC分类号： C12N15/70 , C07K14/005 , C12N9/0008 , C12N9/88 , C12N2795/14222 , C12P21/02 , C12Y102/01 , C12Y403/01007
摘要： The invention described herein relates to methods, systems, compositions and cells to provide one or more toxic non-native proteins in a cell, wherein the one or more toxic non-native proteins are contained in at least one empty microcompartment within the cell.
摘要翻译： 本文描述的本发明涉及在细胞中提供一种或多种有毒非天然蛋白质的方法，系统，组合物和细胞，其中所述一种或多种毒性非天然蛋白质包含在细胞内的至少一个空微室中。
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