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    FLUOROGENIC AND CHROMOGENIC SUBSTRATE
    3.
    发明申请
    FLUOROGENIC AND CHROMOGENIC SUBSTRATE 有权
    荧光和发色基质

    公开(公告)号：US20160266045A1

    公开(公告)日：2016-09-15

    申请号：US15068373

    申请日：2016-03-11

    Applicant: LI-COR, Inc.

    Inventor： Ying Wang ,  Xinshe Xu ,  Nisha Padhye

    IPC: G01N21/78 ,  G01N33/58 ,  G01N21/76 ,  C12Q1/28

    CPC classification number: G01N21/78 ,  C12Q1/28 ,  G01N21/76 ,  G01N33/582

    Abstract: The present invention provides near-infrared fluorogenic and/or chromogenic formulations, methods, systems and kits. Upon contacting an azine with an oxidant and a peroxidase, the azine is converted to an azine derivative which is both visibly colored and fluorescent. This invention also provides high sensitive methods to detect biological molecules, showing better sensitivity than chemiluminescence methods. Advantageously, the formulation and reaction is free of luminol or luminol derivatives.

    Abstract translation: 本发明提供近红外荧光和/或显色制剂，方法，系统和试剂盒。 当将吖嗪与氧化剂和过氧化物酶接触时，吖嗪被转化成浑浊的吖嗪衍生物，它们都是明显的和荧光的。 本发明还提供了检测生物分子的高灵敏度方法，显示出比化学发光方法更好的灵敏度。 有利地，制剂和反应没有鲁米诺或鲁米诺衍生物。

    Hemicyanine dyes
    4.
    发明授权
    Hemicyanine dyes 有权

    公开(公告)号：US11186719B2

    公开(公告)日：2021-11-30

    申请号：US16404993

    申请日：2019-05-07

    Applicant: LI-COR, Inc.

    Inventor： Silvano Sanchini ,  Rose Skopp ,  Vassil Elitzin ,  Nisha Padhye ,  Teresa Urlacher

    IPC: C09B23/01 ,  G01N33/58 ,  C07D209/14 ,  C07D403/12

    Abstract: The present disclosure embodies compounds of Formula I, methods of use thereof, and kits thereof: that are useful in connection with the detection of analytes of all types (e.g., biological molecules such as proteins, organic molecules, natural or synthetic molecules). The disclosure is particularly applicable to detection of proteins and nucleic acids using all types of membrane-based assays by techniques such as Western blotting, Dot blotting, Southern blotting, and Northern blotting.

    HEMICYANINE DYES
    8.
    发明申请
    HEMICYANINE DYES 审中-公开

    公开(公告)号：US20190338131A1

    公开(公告)日：2019-11-07

    申请号：US16404993

    申请日：2019-05-07

    Applicant: LI-COR, Inc.

    Inventor： Silvano Sanchini ,  Rose Skopp ,  Vassil Elitzin ,  Nisha Padhye ,  Teresa Urlacher

    IPC: C09B23/01 ,  G01N33/58

    Abstract: The present disclosure embodies compounds, methods, and kits that are useful in connection with the detection of analytes of all types (e.g., biological molecules such as proteins, organic molecules, natural or synthetic molecules). The disclosure is particularly applicable to detection of proteins and nucleic acids using all types of membrane-based assays by techniques such as Western blotting, Dot blotting, Southern blotting, and Northern blotting.

    Multifunctional protein molecular weight ladders
    9.
    发明授权
    Multifunctional protein molecular weight ladders 有权

    公开(公告)号：US10365290B2

    公开(公告)日：2019-07-30

    申请号：US15491905

    申请日：2017-04-19

    Applicant: LI-COR, Inc.

    Inventor： Nisha Padhye ,  Rose Skopp ,  Ying Wang

    IPC: C07K7/06 ,  G01N33/58 ,  G01N33/96 ,  C07K14/795 ,  C12Q1/28

    Abstract: Multifunctional molecular weight protein ladders and methods of making thereof are disclosed herein that are useful for determining the molecular weight of a test protein and/or the relative mass or amount of the test protein in a protein separation assay, such as gel electrophoresis or western blotting. Also included are compounds of Formula I (e.g., mono acetylated MP-11 NHS ester) that may be used to label purified proteins of the protein ladder. The MP-11 label protein ladder can be detected on a blotting membrane by exposing the microperoxidase to a suitable substrate, such as a chromogenic substrate or a chemiluminescent substrate.

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