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公开(公告)号：US09470691B2
公开(公告)日：2016-10-18
申请号：US14192827
申请日：2014-02-27
Applicant: LI-COR, INC.
Inventor： Kousik Kundu , Nisha Padhye , William Volcheck
CPC classification number: C09B23/164 , C07D209/08 , C09B23/0008 , C09B23/0025 , C09B23/0066 , C09B23/083 , C09B23/086 , C09B23/107 , G01N33/574 , G01N33/582
Abstract: The present invention provides novel compounds and methods for hydrocyanines derived from near-infrared cyanine dyes, as reactive oxygen species probes in imaging. In certain embodiments, the present invention provides reduced dyes as substrates for ELISA and Western blots.
Abstract translation: 本发明提供了新型化合物和衍生自近红外花青染料的氢氰酸的新型化合物和方法，作为成像中的活性氧探针。 在某些实施方案中，本发明提供还原染料作为用于ELISA和Western印迹的底物。
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Patent Agency Ranking
公开(公告)号：US20130280172A1
公开(公告)日：2013-10-24
申请号：US13836202
申请日：2013-03-15
Applicant: LI-COR, INC.
Inventor： Xinshe Xu , Daniel R. Draney , Mark Cradduck , Lael Cheung , Kousik Kundu , William M. Volcheck
IPC: A61K49/00
CPC classification number: A61K49/0058 , A61K49/0032 , A61K49/0052 , C07D471/04 , C07F9/6561 , C07K19/00 , C08B37/0072 , C09B23/0008 , C09B23/0016 , C09B23/0025 , C09B23/0066 , C09B23/083 , C09B23/086 , C09B69/00 , G01N33/574 , G01N33/58 , G01N33/582
Abstract: Compounds and methods are disclosed that are useful for noninvasive imaging in the near-infrared spectral range. The cyanine compounds of Formula I are presented: wherein Q is a portion of a polymethine bridge: Also included are bioconjugates of the compounds of Formula I, methods of labeling biomolecules with the compounds, and methods of imaging.
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公开(公告)号：US10100198B2
公开(公告)日：2018-10-16
申请号：US15258283
申请日：2016-09-07
Applicant: LI-COR, Inc.
Inventor： Kousik Kundu , Nisha Padhye , William Volcheck
IPC: A61B10/00 , A61B5/00 , A61B8/00 , C09B23/16 , G01N33/58 , C07D209/08 , C09B23/01 , C09B23/08 , C09B23/10 , G01N33/574
Abstract: The present invention provides novel compounds and methods for hydrocyanines derived from near-infrared cyanine dyes, as reactive oxygen species probes in imaging. In certain embodiments, the present invention provides reduced dyes as substrates for ELISA and Western blots.
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公开(公告)号：US20170130050A1
公开(公告)日：2017-05-11
申请号：US15258283
申请日：2016-09-07
Applicant: LI-COR, Inc.
Inventor： Kousik Kundu , Nisha Padhye , William Volcheck
IPC: C09B23/16 , G01N33/574 , C09B23/10 , G01N33/58
CPC classification number: C09B23/164 , C07D209/08 , C09B23/0008 , C09B23/0025 , C09B23/0066 , C09B23/083 , C09B23/086 , C09B23/107 , G01N33/574 , G01N33/582
Abstract: The present invention provides novel compounds and methods for hydrocyanines derived from near-infrared cyanine dyes, as reactive oxygen species probes in imaging. In certain embodiments, the present invention provides reduced dyes as substrates for ELISA and Western blots.
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公开(公告)号：US09089603B2
公开(公告)日：2015-07-28
申请号：US13836202
申请日：2013-03-15
Applicant: LI-COR, INC.
Inventor： Xinshe Xu , Daniel R. Draney , Mark Cradduck , Lael Cheung , Kousik Kundu , William M. Volcheck
IPC: C07D471/04 , A61K49/00 , C09B23/01 , C09B23/08 , C09B69/00 , G01N33/574 , G01N33/58 , C07F9/6561 , C07K19/00 , C08B37/08
CPC classification number: A61K49/0058 , A61K49/0032 , A61K49/0052 , C07D471/04 , C07F9/6561 , C07K19/00 , C08B37/0072 , C09B23/0008 , C09B23/0016 , C09B23/0025 , C09B23/0066 , C09B23/083 , C09B23/086 , C09B69/00 , G01N33/574 , G01N33/58 , G01N33/582
Abstract: Compounds and methods are disclosed that are useful for noninvasive imaging in the near-infrared spectral range. The cyanine compounds of Formula I are presented: wherein Q is a portion of a polymethine bridge: Also included are bioconjugates of the compounds of Formula I, methods of labeling biomolecules with the compounds, and methods of imaging.
Abstract translation: 公开了可用于近红外光谱范围内的无创成像的化合物和方法。 呈现式I的花青化合物：其中Q是聚甲炔桥的一部分：还包括式I化合物的生物缀合物，用化合物标记生物分子的方法和成像方法。
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公开(公告)号：US20140213473A1
公开(公告)日：2014-07-31
申请号：US14192827
申请日：2014-02-27
Applicant: LI-COR, INC.
Inventor： Kousik Kundu , Nisha Padhye , William Volcheck
IPC: G01N33/58
CPC classification number: C09B23/164 , C07D209/08 , C09B23/0008 , C09B23/0025 , C09B23/0066 , C09B23/083 , C09B23/086 , C09B23/107 , G01N33/574 , G01N33/582
Abstract: The present invention provides novel compounds and methods for hydrocyanines derived from near-infrared cyanine dyes, as reactive oxygen species probes in imaging. In certain embodiments, the present invention provides reduced dyes as substrates for ELISA and Western blots.
Abstract translation: 本发明提供了新型化合物和衍生自近红外花青染料的氢氰酸的新型化合物和方法，作为成像中的活性氧探针。 在某些实施方案中，本发明提供还原染料作为用于ELISA和Western印迹的底物。
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