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公开(公告)号：US20180079954A1
公开(公告)日：2018-03-22
申请号：US15825339
申请日：2017-11-29
Applicant: LI-COR, INC.
Inventor： Xinshe Xu , Rose Skopp , Mark Cradduck , Nisha Padhye
CPC classification number: C09K11/07 , B43K1/12 , C09K2211/1029 , C09K2211/188 , F21K2/06
Abstract: The present invention provides a chemiluminescent ink formulation, comprising: a phthalocyanine metal catalyst; a visible dye; and a solvent. The formulation is useful in catalyzing a chemiluminescent reaction, by admixing for example, luminol or isoluminol with an oxidizing agent, a base and the chemiluminescent ink formulation to emit light.
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公开(公告)号：US09408924B2
公开(公告)日：2016-08-09
申请号：US14552396
申请日：2014-11-24
Applicant: LI-COR, INC.
Inventor： Xinshe Xu , Daniel R. Draney , Lael Cheung
IPC: C07D401/06 , C07D471/04 , A61K49/00 , C09B23/01 , C09B23/08 , C09B69/00 , G01N33/574 , G01N33/58 , C07F9/6561 , C07K19/00 , C08B37/08
CPC classification number: A61K49/0058 , A61K49/0032 , A61K49/0052 , C07D471/04 , C07F9/6561 , C07K19/00 , C08B37/0072 , C09B23/0008 , C09B23/0016 , C09B23/0025 , C09B23/0066 , C09B23/083 , C09B23/086 , C09B69/00 , G01N33/574 , G01N33/58 , G01N33/582
Abstract: Compounds are disclosed that are useful for noninvasive imaging in the near-infrared spectral range. Bioconjugate cyanine compounds of Formula II are presented: wherein Q is a portion of a polymethine bridge selected from the group consisting of:
Abstract translation: 公开了可用于近红外光谱范围内的无创成像的化合物。 提供了式II的生物共轭花青化合物：其中Q是选自以下的聚甲炔桥的一部分：
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公开(公告)号：US10988687B2
公开(公告)日：2021-04-27
申请号：US15825339
申请日：2017-11-29
Applicant: LI-COR, INC.
Inventor： Xinshe Xu , Rose Skopp , Mark Cradduck , Nisha Padhye
Abstract: The present invention provides a chemiluminescent ink formulation, comprising: a phthalocyanine metal catalyst; a visible dye; and a solvent. The formulation is useful in catalyzing a chemiluminescent reaction, by admixing for example, luminol or isoluminol with an oxidizing agent, a base and the chemiluminescent ink formulation to emit light.
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公开(公告)号：US20160266045A1
公开(公告)日：2016-09-15
申请号：US15068373
申请日：2016-03-11
Applicant: LI-COR, Inc.
Inventor： Ying Wang , Xinshe Xu , Nisha Padhye
CPC classification number: G01N21/78 , C12Q1/28 , G01N21/76 , G01N33/582
Abstract: The present invention provides near-infrared fluorogenic and/or chromogenic formulations, methods, systems and kits. Upon contacting an azine with an oxidant and a peroxidase, the azine is converted to an azine derivative which is both visibly colored and fluorescent. This invention also provides high sensitive methods to detect biological molecules, showing better sensitivity than chemiluminescence methods. Advantageously, the formulation and reaction is free of luminol or luminol derivatives.
Abstract translation: 本发明提供近红外荧光和/或显色制剂，方法，系统和试剂盒。 当将吖嗪与氧化剂和过氧化物酶接触时，吖嗪被转化成浑浊的吖嗪衍生物，它们都是明显的和荧光的。 本发明还提供了检测生物分子的高灵敏度方法，显示出比化学发光方法更好的灵敏度。 有利地，制剂和反应没有鲁米诺或鲁米诺衍生物。
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公开(公告)号：US20130280172A1
公开(公告)日：2013-10-24
申请号：US13836202
申请日：2013-03-15
Applicant: LI-COR, INC.
Inventor： Xinshe Xu , Daniel R. Draney , Mark Cradduck , Lael Cheung , Kousik Kundu , William M. Volcheck
IPC: A61K49/00
CPC classification number: A61K49/0058 , A61K49/0032 , A61K49/0052 , C07D471/04 , C07F9/6561 , C07K19/00 , C08B37/0072 , C09B23/0008 , C09B23/0016 , C09B23/0025 , C09B23/0066 , C09B23/083 , C09B23/086 , C09B69/00 , G01N33/574 , G01N33/58 , G01N33/582
Abstract: Compounds and methods are disclosed that are useful for noninvasive imaging in the near-infrared spectral range. The cyanine compounds of Formula I are presented: wherein Q is a portion of a polymethine bridge: Also included are bioconjugates of the compounds of Formula I, methods of labeling biomolecules with the compounds, and methods of imaging.
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Patent Agency Ranking
公开(公告)号：US20130274452A1
公开(公告)日：2013-10-17
申请号：US13831345
申请日：2013-03-14
Applicant: Li-Cor, Inc.
Inventor： Xinshe Xu , Daniel R. Draney , Lael Cheung
IPC: C07D471/04
CPC classification number: A61K49/0058 , A61K49/0032 , A61K49/0052 , C07D471/04 , C07F9/6561 , C07K19/00 , C08B37/0072 , C09B23/0008 , C09B23/0016 , C09B23/0025 , C09B23/0066 , C09B23/083 , C09B23/086 , C09B69/00 , G01N33/574 , G01N33/58 , G01N33/582
Abstract: Compounds and methods are disclosed that are useful for noninvasive imaging in the near-infrared spectral range. The cyanine compounds of Formula I are presented: wherein Q is a portion of a polymethine bridge selected from the group consisting of: Also included are bioconjugates of the compounds of Formula I, methods of labeling biomolecules with the compounds, and methods of imaging.
Abstract translation: 公开了可用于近红外光谱范围内的无创成像的化合物和方法。 呈现式I的花青化合物：其中Q是选自以下的聚甲炔桥的一部分：还包括式I化合物的生物缀合物，用化合物标记生物分子的方法和成像方法。
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公开(公告)号：US09845430B2
公开(公告)日：2017-12-19
申请号：US14262659
申请日：2014-04-25
Applicant: LI-COR, INC.
Inventor： Xinshe Xu , Rose Skopp , Mark Cradduck , Nisha Padhye
CPC classification number: C09K11/07 , B43K1/12 , C09K2211/1029 , C09K2211/188 , F21K2/06
Abstract: The present invention provides a chemiluminescent ink formulation, comprising: a phthalocyanine metal catalyst; a visible dye; and a solvent. The formulation is useful in catalyzing a chemiluminescent reaction, by admixing for example, luminol or isoluminol with an oxidizing agent, a base and the chemiluminescent ink formulation to emit light.
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公开(公告)号：US09089603B2
公开(公告)日：2015-07-28
申请号：US13836202
申请日：2013-03-15
Applicant: LI-COR, INC.
Inventor： Xinshe Xu , Daniel R. Draney , Mark Cradduck , Lael Cheung , Kousik Kundu , William M. Volcheck
IPC: C07D471/04 , A61K49/00 , C09B23/01 , C09B23/08 , C09B69/00 , G01N33/574 , G01N33/58 , C07F9/6561 , C07K19/00 , C08B37/08
CPC classification number: A61K49/0058 , A61K49/0032 , A61K49/0052 , C07D471/04 , C07F9/6561 , C07K19/00 , C08B37/0072 , C09B23/0008 , C09B23/0016 , C09B23/0025 , C09B23/0066 , C09B23/083 , C09B23/086 , C09B69/00 , G01N33/574 , G01N33/58 , G01N33/582
Abstract: Compounds and methods are disclosed that are useful for noninvasive imaging in the near-infrared spectral range. The cyanine compounds of Formula I are presented: wherein Q is a portion of a polymethine bridge: Also included are bioconjugates of the compounds of Formula I, methods of labeling biomolecules with the compounds, and methods of imaging.
Abstract translation: 公开了可用于近红外光谱范围内的无创成像的化合物和方法。 呈现式I的花青化合物：其中Q是聚甲炔桥的一部分：还包括式I化合物的生物缀合物，用化合物标记生物分子的方法和成像方法。
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公开(公告)号：US08927719B2
公开(公告)日：2015-01-06
申请号：US13831345
申请日：2013-03-14
Applicant: Li-Cor, Inc.
Inventor： Xinshe Xu , Daniel R. Draney , Lael Cheung
IPC: C07D401/06 , A61K49/00 , C09B23/08 , G01N33/58 , C07D471/04 , G01N33/574 , C09B23/01 , C09B69/00
CPC classification number: A61K49/0058 , A61K49/0032 , A61K49/0052 , C07D471/04 , C07F9/6561 , C07K19/00 , C08B37/0072 , C09B23/0008 , C09B23/0016 , C09B23/0025 , C09B23/0066 , C09B23/083 , C09B23/086 , C09B69/00 , G01N33/574 , G01N33/58 , G01N33/582
Abstract: Compounds and methods are disclosed that are useful for noninvasive imaging in the near-infrared spectral range. The cyanine compounds of Formula I are presented: wherein Q is a portion of a polymethine bridge selected from the group consisting of: Also included are bioconjugates of the compounds of Formula I, methods of labeling biomolecules with the compounds, and methods of imaging.
Abstract translation: 公开了可用于近红外光谱范围内的无创成像的化合物和方法。 呈现式I的花青化合物：其中Q是选自以下的聚甲炔桥的一部分：还包括式I化合物的生物缀合物，用化合物标记生物分子的方法和成像方法。
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公开(公告)号：US09632034B2
公开(公告)日：2017-04-25
申请号：US15068373
申请日：2016-03-11
Applicant: LI-COR, Inc.
Inventor： Ying Wang , Xinshe Xu , Nisha Padhye
CPC classification number: G01N21/78 , C12Q1/28 , G01N21/76 , G01N33/582
Abstract: The present invention provides near-infrared fluorogenic and/or chromogenic formulations, methods, systems and kits. Upon contacting an azine with an oxidant and a peroxidase, the azine is converted to an azine derivative which is both visibly colored and fluorescent. This invention also provides high sensitive methods to detect biological molecules, showing better sensitivity than chemiluminescence methods. Advantageously, the formulation and reaction is free of luminol or luminol derivatives.
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