公开(公告)号：US10746695B2

公开(公告)日：2020-08-18

申请号：US15124129

申请日：2015-03-06

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Ian Walton ,  Robert Cobene ,  Alexander Dukhovny ,  Adam Sannicandro ,  John Dixon ,  Achim Karger ,  Dan Kline

IPC: G01N27/447 ,  G01N35/10

Abstract: In one aspect, a biological sequencing device comprising a cartridge configured to be removed from the instrument is disclosed. In various embodiments the cartridge can include one or more capillaries suitable for capillary electrophoresis, a reservoir and a pump. In various embodiments the reservoir can contain a separation matrix. In various embodiments the pump can load a capillary with separation matrix. In another aspect the biological sequencing device can include one or more capillaries and an integrated valve assembly. In various embodiments the integrated valve assembly can provide a polymer to the one or more capillaries.

公开(公告)号：US11754524B2

公开(公告)日：2023-09-12

申请号：US16922754

申请日：2020-07-07

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Ian Walton ,  Robert Cobene ,  Alexander Dukhovny ,  Adam Sannicandro ,  John Dixon ,  Achim Karger ,  Dan Kline

IPC: G01N27/453 ,  G01N27/447 ,  G01N35/10

CPC classification number: G01N27/44791 ,  G01N27/44708 ,  G01N27/44721 ,  G01N27/44743 ,  G01N27/44756 ,  G01N35/1016 ,  G01N35/10

Abstract: In one aspect, a biological sequencing device comprising a cartridge configured to be removed from the instrument is disclosed. In various embodiments the cartridge can include one or more capillaries suitable for capillary electrophoresis, a reservoir and a pump. In various embodiments the reservoir can contain a separation matrix. In various embodiments the pump can load a capillary with separation matrix. In another aspect the biological sequencing device can include one or more capillaries and an integrated valve assembly. In various embodiments the integrated valve assembly can provide a polymer to the one or more capillaries.

公开(公告)号：US20170176385A1

公开(公告)日：2017-06-22

申请号：US15124168

申请日：2015-03-06

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Ian Walton ,  Achim Karger ,  Alexander Khorlin ,  Michael Simon ,  Adam Sannicandro ,  Alexander Dukhovny ,  Robert Cobene ,  Dan Kline ,  John Dixon

IPC: G01N27/447

CPC classification number: G01N27/44791 ,  G01N27/44704 ,  G01N27/44743 ,  G01N27/44756

Abstract: The present disclosure relates, in some embodiments, to an apparatus for conducting a capillary electrophoresis assay. The apparatus can comprise a capillary array comprising an anode end and a cathode end, the capillary array provided in a housing further comprising a reservoir configured to house a separation medium and an anode buffer. The system can also comprise an injection mechanism configured to deliver sample to the cathode end of the capillary array, and a temperature control zone, wherein the temperature control zone is configured to control the temperature of the interior of the housing.

公开(公告)号：US20170176384A1

公开(公告)日：2017-06-22

申请号：US15124129

申请日：2015-03-06

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Ian Walton ,  Robert Cobene ,  Alexander Dukhovny ,  Adam Sannicandro ,  John Dixon ,  Achim Karger ,  Dan Kline

IPC: G01N27/447 ,  G01N35/10

Abstract: In one aspect, a biological sequencing device comprising a cartridge configured to be removed from the instrument is disclosed. In various embodiments the cartridge can include one or more capillaries suitable for capillary electrophoresis, a reservoir and a pump. In various embodiments the reservoir can contain a separation matrix. In various embodiments the pump can load a capillary with separation matrix. In another aspect the biological sequencing device can include one or more capillaries and an integrated valve assembly. In various embodiments the integrated valve assembly can provide a polymer to the one or more capillaries.

公开(公告)号：US10274460B2

公开(公告)日：2019-04-30

申请号：US15124168

申请日：2015-03-06

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Ian Walton ,  Achim Karger ,  Alexander Khorlin ,  Michael Simon ,  Adam Sannicandro ,  Alexander Dukhovny ,  Robert Cobene ,  Dan Kline ,  John Dixon

IPC: G01N27/447

Abstract: The present disclosure relates, in some embodiments, to an apparatus for conducting a capillary electrophoresis assay. The apparatus can comprise a capillary array comprising an anode end and a cathode end, the capillary array provided in a housing further comprising a reservoir configured to house a separation medium and an anode buffer. The system can also comprise an injection mechanism configured to deliver sample to the cathode end of the capillary array, and a temperature control zone, wherein the temperature control zone is configured to control the temperature of the interior of the housing.