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公开(公告)号：US20160334393A1
公开(公告)日：2016-11-17
申请号：US15221230
申请日：2016-07-27
发明人： Kyle GEE , Michael JANES , Iain JOHNSON , Hee Chol KANG
IPC分类号： G01N33/52 , G01N33/58 , C07F9/54 , C07D491/16 , C07K5/02
CPC分类号： G01N33/52 , C07D491/06 , C07D491/16 , C07F9/5442 , C07K5/0215 , G01N33/582 , G01N2333/4701 , Y10T436/17 , Y10T436/182
摘要： Fluorescent quinolizinocoumarin compounds substituted with electrophilic reactive groups that bind thiol compounds are described. The compounds are useful in detecting oxidative stress and processes associated therewith in live cells.
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公开(公告)号：US20170073359A1
公开(公告)日：2017-03-16
申请号：US15276241
申请日：2016-09-26
发明人： Schuyler CORRY , William DOWNEY , Brian FILANOSKI , Kyle GEE , Lawrence GREENFIELD , James HIRSCH , Iain JOHNSON , Aleksey RUKAVISHNIKOV
IPC分类号： C07F5/02 , C07D519/00 , C07D501/60 , G01N33/58 , C07D501/58
CPC分类号： C07F5/022 , C07D499/00 , C07D501/00 , C07D501/58 , C07D501/60 , C07D503/00 , C07D519/00 , C12Q1/34 , C12Q2334/00 , G01N33/581 , G01N2333/986
摘要： The present invention relates to compounds that are substrates for an enzyme, and upon reaction with the enzyme provide a detectable response, such as an optically detectable response. In particular, the compounds have utility in detecting the presence of a β-lactamase in a sample. In addition to the compounds, methods are disclosed for analyzing a sample for the presence of a β-lactmase, for example, as an indicator of expression of a nucleic acid sequence including a sequence coding for a β-lactmase. Kits are disclosed that include the disclosed compounds and additional components, for example, cells, antibodies, a β-lactmase or instructions for using the components in an assay.
摘要翻译： 本发明涉及作为酶的底物的化合物，并且在与酶反应时提供可检测的反应，例如可光学检测的反应。 特别地，这些化合物可用于检测样品中β-内酰胺酶的存在。 除了化合物之外，还公开了用于分析β-乳酸酶存在的样品的方法，例如作为包括编码β-内酰胺酶的序列的核酸序列的表达的指标。 公开了包括所公开的化合物和另外的组分的试剂盒，例如细胞，抗体，β-内酰胺酶或在测定中使用组分的说明书。
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公开(公告)号：US20170037248A1
公开(公告)日：2017-02-09
申请号：US15299841
申请日：2016-10-21
发明人： Robert Batchelor , Yue GE , Iain JOHNSON , Wai-Yee LEUNG , Jixiang LIU , Brian PATCH , Peter SMALLEY , Thomas STEINBERG , Kyle GEE
IPC分类号： C09B19/00 , C12Q1/28 , C07D495/04 , C07D265/38 , C07D413/12
CPC分类号： C09B19/00 , C07D265/38 , C07D413/12 , C07D495/04 , C12Q1/28
摘要： The invention provides novel fluorinated resorufin compounds that are of use in a variety of assay formats. Also provided are methods of using the compounds and kits that include a compound of the invention and instructions detailing the use of the compound in one or more assay formats.
摘要翻译： 本发明提供可用于各种测定形式的新型氟化聚砜化合物。 还提供了使用包含本发明化合物的化合物和试剂盒的方法以及详细说明化合物在一种或多种测定形式中的用途的说明书。
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公开(公告)号：US20140220612A1
公开(公告)日：2014-08-07
申请号：US14247619
申请日：2014-04-08
发明人： Robert BATCHELOR , Yue GE , Iain JOHNSON , Wai-Yee LEUNG , Jixiang LIU , Brian PATCH , Peter SMALLEY , Thomas STEINBERG , Kyle GEE
CPC分类号： C09B19/00 , C07D265/38 , C07D413/12 , C07D495/04 , C12Q1/28
摘要： The invention provides novel fluorinated resorufin compounds that are of use in a variety of assay formats. Also provided are methods of using the compounds and kits that include a compound of the invention and instructions detailing the use of the compound in one or more assay formats.
摘要翻译： 本发明提供可用于各种测定形式的新型氟化聚砜化合物。 还提供了使用包括本发明化合物的化合物和试剂盒的方法以及详细说明化合物在一种或多种测定形式中的用途的说明书。
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