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公开(公告)号：US20150037834A1
公开(公告)日：2015-02-05
申请号：US14455550
申请日：2014-08-08
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Daniel BEACHAM , Jeffrey DZUBAY , Kyle GEE , Vladimir MARTIN , Aleksey RUKAVISHNIKOV
IPC: G01N33/50
CPC classification number: G01N33/84 , C07D209/14 , C07D311/82 , C07D311/90 , C07D405/12 , C07D413/04 , C07D491/22 , C07F5/02 , C07K1/13 , C09B7/00 , C09B11/12 , C09B11/24 , C09B11/28 , C09B57/00 , C09B69/00 , C09K11/06 , G01N31/22 , G01N33/5005 , G01N33/5058 , G01N33/5091 , G01N33/582 , G01N33/80 , G01N2333/245 , Y10T436/143333
Abstract: A new class of pH sensitive fluorescent dyes and assays relating thereto are described. The dyes and assays are particularly suited for biological applications including phagocytosis and monitoring intracellular processes. The pH sensitive fluorescent dyes of the present invention include compounds of Formula I: wherein the variables are described throughout the application.
Abstract translation: 描述了一类新的pH敏感荧光染料和与其相关的测定。 染料和测定特别适用于生物学应用，包括吞噬和监测细胞内过程。 本发明的pH敏感荧光染料包括式I化合物：其中在整个申请中描述了变量。
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公开(公告)号：US20160139158A1
公开(公告)日：2016-05-19
申请号：US14937736
申请日：2015-11-10
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Jeffrey DZUBAY , Kyle GEE , Vladimir MARTIN , Aleksey RUKAVISHNIKOV , Daniel BEACHAM
CPC classification number: G01N33/84 , C07D209/14 , C07D311/82 , C07D311/90 , C07D405/12 , C07D413/04 , C07D491/22 , C07F5/02 , C07K1/13 , C09B7/00 , C09B11/12 , C09B11/24 , C09B11/28 , C09B57/00 , C09B69/00 , C09K11/06 , G01N31/22 , G01N33/5005 , G01N33/5058 , G01N33/5091 , G01N33/582 , G01N33/80 , G01N2333/245 , Y10T436/143333
Abstract: A new class of pH sensitive fluorescent dyes and assays relating thereto are described. The dyes and assays are particularly suited for biological applications including phagocytosis and monitoring intracellular processes. The pH sensitive fluorescent dyes of the present invention include compounds of Formula I: wherein the variables are described throughout the application.
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公开(公告)号：US20210041465A1
公开(公告)日：2021-02-11
申请号：US17027391
申请日：2020-09-21
Applicant: Life Technologies Corporation
Inventor： Jeffrey DZUBAY , Kyle Gee , Vladimir Martin , Aleksey Rukavishnikov , Daniel Beacham
IPC: G01N33/84 , C07D311/82 , C07D311/90 , C07D405/12 , C07D413/04 , C07D491/22 , C07D209/14 , C09K11/06 , C07F5/02 , C07K1/13 , C09B7/00 , C09B11/12 , C09B11/28 , C09B57/00 , C09B69/00 , G01N31/22 , G01N33/50 , C09B11/24 , G01N33/58 , G01N33/80
Abstract: A new class of pH sensitive fluorescent dyes and assays relating thereto are described. The dyes and assays are particularly suited for biological applications including phagocytosis and monitoring intracellular processes. The pH sensitive fluorescent dyes of the present invention include compounds of Formula I: wherein the variables are described throughout the application.
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公开(公告)号：US20180238912A1
公开(公告)日：2018-08-23
申请号：US15899021
申请日：2018-02-19
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Jeffrey DZUBAY , Kyle Gee , Vladimir Martin , Aleksey Rukavishnikov , Daniel Beacham
IPC: G01N33/84 , C09B11/24 , C07K1/13 , C09B7/00 , C09B11/12 , C09B11/28 , C09B57/00 , G01N31/22 , G01N33/50 , G01N33/58 , C09K11/06 , C07D311/82 , C07D311/90 , C07D405/12 , C07D413/04 , C07D491/22 , C07D209/14 , C07F5/02 , C09B69/00 , G01N33/80
CPC classification number: G01N33/84 , C07D209/14 , C07D311/82 , C07D311/90 , C07D405/12 , C07D413/04 , C07D491/22 , C07F5/02 , C07K1/13 , C09B7/00 , C09B11/12 , C09B11/24 , C09B11/28 , C09B57/00 , C09B69/00 , C09K11/06 , G01N31/22 , G01N33/5005 , G01N33/5058 , G01N33/5091 , G01N33/582 , G01N33/80 , G01N2333/245 , Y10T436/143333
Abstract: A new class of pH sensitive fluorescent dyes and assays relating thereto are described. The dyes and assays are particularly suited for biological applications including phagocytosis and monitoring intracellular processes. The pH sensitive fluorescent dyes of the present invention include compounds of Formula I: wherein the variables are described throughout the application.
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