公开(公告)号：US20240263196A1

公开(公告)日：2024-08-08

申请号：US18398730

申请日：2023-12-28

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Jian LIU ,  Neha PARAYATH ,  Evgenia VEROVSKAYA

IPC: C12N15/88 ,  C12N9/22 ,  C12N15/11

CPC classification number: C12N15/88 ,  C12N9/22 ,  C12N15/11 ,  C12N2310/20

Abstract: Provided herein, are methods, compositions, and kits for introducing a payload to an immune cell. In aspects, a lipid composition is described, which includes at least one ionizable lipid compound having the structure I. In aspects, the methods and compositions are for introducing a nucleic acid payload into immune cells, for example T cells, dendritic cells, and NK cells.