公开(公告)号：US20240043794A1

公开(公告)日：2024-02-08

申请号：US18257534

申请日：2021-12-15

Applicant: Life Technologies Corporation

Inventor： Joel JESSEE ,  David KUNINGER ,  Soojung SHIN

IPC: C12N5/00 ,  C12N9/02

CPC classification number: C12N5/0037 ,  C12N9/0089 ,  C12Y115/01001 ,  C12N2501/71 ,  C12N2500/90 ,  C12N2500/38

Abstract: Provided herein, inter alia, are chemically defined components and compositions that substitute or partially substitute for albumin in cell culture media. The components and compositions may support cell cultures, protect cells, or enhance viability of cultured cells. Further provided are chemically defined culture media supplements for use in cell culture media containing albumin. The chemically defined culture media supplements may rescue cells from albumin-induced toxicity.

公开(公告)号：US20230279346A1

公开(公告)日：2023-09-07

申请号：US18161546

申请日：2023-01-30

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Soojung SHIN ,  Yiping YAN ,  Daniel BEACHAM

IPC: C12N5/0793 ,  C12N5/00 ,  C12N5/0735 ,  C12N5/074

CPC classification number: C12N5/0619 ,  C12N5/0031 ,  C12N5/0037 ,  C12N5/0606 ,  C12N5/0696 ,  C12N2500/99 ,  C12N2501/42 ,  C12N2506/08

Abstract: Embodiments herein provide methods of differentiating neural stem cells to neuronal cells while concomitantly retarding neural stem cell proliferation. Resultant cultures demonstrate reduced clumping of cells, increased purity of neuronal cells and accelerated electrophysiology as compared to control methods.

公开(公告)号：US20190241869A1

公开(公告)日：2019-08-08

申请号：US16344497

申请日：2017-10-20

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Soojung SHIN ,  Yiping YAN ,  Daniel BEACHAM

IPC: C12N5/0793 ,  C12N5/00 ,  C12N5/0735 ,  C12N5/074

CPC classification number: C12N5/0619 ,  C12N5/0031 ,  C12N5/0037 ,  C12N5/0606 ,  C12N5/0696 ,  C12N2500/99 ,  C12N2501/42 ,  C12N2506/08

Abstract: Embodiments herein provide methods of differentiating neural stem cells to neuronal cells while concomitantly retarding neural stem cell proliferation. Resultant cultures demonstrate reduced clumping of cells, increased purity of neuronal cells and accelerated electrophysiology as compared to control methods.