公开(公告)号：US11744806B2

公开(公告)日：2023-09-05

申请号：US16772775

申请日：2018-12-13

Applicant: LTS Lohmann Therapie-Systeme AG

Inventor： Michael Linn ,  Christoph Schmitz ,  Hanshermann Franke

IPC: A61K9/70 ,  A61K9/00 ,  A61K31/4045 ,  A61K47/12 ,  A61K47/34

CPC classification number: A61K9/703 ,  A61K9/0009 ,  A61K31/4045 ,  A61K47/12 ,  A61K47/34

Abstract: The present invention relates to frigostable compositions suitable for iontophoretic transdermal delivery of a triptan compound. The inventive compositions include a salt of a triptan compound, preferably sumatriptan succinate, a polyamine, a dicarboxylic acid, and water or an aqueous solvent mixture, with the composition being free of monocarboxylic acids. The invention further relates to the use of the composition as an integral component of an iontophoretic patch, preferably as an anodic reservoir of the patch.

公开(公告)号：US11992561B2

公开(公告)日：2024-05-28

申请号：US17900616

申请日：2022-08-31

Applicant: LTS LOHMANN THERAPIE-SYSTEME AG

Inventor： Markus Müller ,  Mario Ficker ,  Michael Linn ,  Florian Hammes

IPC: A61K9/70 ,  A61K9/00 ,  A61K31/135 ,  A61K47/10 ,  A61K47/32

CPC classification number: A61K9/7007 ,  A61K9/006 ,  A61K31/135 ,  A61K47/10 ,  A61K47/32

Abstract: Described is an oral thin film comprising at least one matrix layer, wherein the at least one matrix layer comprises at least one pharmaceutically active agent, at least one polyvinyl alcohol and at least one polyvinyl alcohol-polyethylene glycol graft copolymer, a method for producing same, and use thereof as a medicament.

公开(公告)号：US11213491B2

公开(公告)日：2022-01-04

申请号：US16094933

申请日：2017-04-20

Applicant: LTS Lohmann Therapie-Systeme AG

Inventor： Markus Müller ,  Claudia Maria Hammes ,  Christoph Schmitz ,  Michael Linn ,  Mohammad Sameti ,  Peter Klaffenbach

IPC: A61K9/70 ,  A61K38/28 ,  A61K47/38 ,  A61P3/10 ,  A61P9/00 ,  A61K9/00 ,  A61K38/26

Abstract: The invention relates to film-like forms of administration for the transmucosal delivery of antidiabetic peptides via the oral mucosa and to processes for the production thereof. Antidiabetic peptides refers to peptides which are an active compound for the treatment of diabetes mellitus, and includes insulins, insulin analogs, incretins and incretin mimetics.

公开(公告)号：US12054335B2

公开(公告)日：2024-08-06

申请号：US18119897

申请日：2023-03-10

Applicant: LTS LOHMANN THERAPIE-SYSTEME AG

Inventor： Marc Blomenkemper ,  Michael Linn ,  Ronald Hackbarth ,  Markus Bee

IPC: A61J7/00 ,  B65D83/08 ,  B65H16/00 ,  B65H35/00

CPC classification number: B65D83/0829 ,  A61J7/0053 ,  A61J7/0076 ,  B65D83/0841 ,  B65H16/005 ,  B65H35/0086 ,  B65H35/0093 ,  B65H2403/941 ,  B65H2404/14

Abstract: A device for dispensing active ingredient-containing or active ingredient-carrying strips, including a housing in which a coil chamber for receiving an active ingredient-containing or active ingredient-carrying band is arranged, in which a gear transmission with a driven roller for conveying the band is mounted, and in which a separating device for separating the strips from the band is arranged. A method for dispensing active ingredient-containing or active ingredient carrying strips using such a device is also disclosed. An active ingredient-containing or active ingredient-carrying band is arranged between the driven roller and the pressure roller. A shift clutch transmission having a manually actuatable trigger element is arranged upstream of the gear transmission. The driven roller can be driven in incremental strips by the shift clutch transmission. A device and method is disclosed for dispensing active ingredient-containing or active ingredient-carrying strips with a largely equal dosage are developed.

公开(公告)号：US11304912B2

公开(公告)日：2022-04-19

申请号：US16765800

申请日：2018-11-21

Applicant: LTS LOHMANN THERAPIE-SYSTEME AG

Inventor： Michael Linn ,  Markus Müller ,  Marius Bauer

IPC: A61K9/70 ,  A61K31/122 ,  A61K31/24 ,  A61K31/506 ,  A61K31/381 ,  A61K31/4545 ,  A61K31/135 ,  A61K31/663 ,  A61K31/4468

Abstract: The present application relates to a transdermal therapeutic system comprising a backing layer impermeable to active substances and a polymer matrix on one side of the backing layer impermeable to active substances, wherein the polymer matrix comprises at least one pharmaceutically active substance, at least one inherently non-self-adhesive polymer and at least one plasticizer, said polymer matrix being free of adhesive polymers. The invention further relates to a method of producing the transdermal therapeutic system and to the use thereof as a drug.

公开(公告)号：US11634268B2

公开(公告)日：2023-04-25

申请号：US17145534

申请日：2021-01-11

Applicant: LTS LOHMANN THERAPIE-SYSTEME AG

Inventor： Marc Blomenkemper ,  Michael Linn ,  Ronald Hackbarth ,  Markus Bee

IPC: B65D83/08 ,  A61J7/00

Abstract: A device for dispensing active ingredient-containing or active ingredient-carrying strips, including a housing in which a coil chamber for receiving an active ingredient-containing or active ingredient-carrying band is arranged, in which a gear transmission with a driven roller for conveying the band is mounted, and in which a separating device for separating the strips from the band is arranged. A method for dispensing active ingredient-containing or active ingredient carrying strips using such a device is also disclosed. An active ingredient-containing or active ingredient-carrying band is arranged between the driven roller and the pressure roller. A shift clutch transmission having a manually actuatable trigger element is arranged upstream of the gear transmission. The driven roller can be driven in incremental strips by the shift clutch transmission. A device and method is disclosed for dispensing active ingredient-containing or active ingredient-carrying strips with a largely equal dosage are developed.

公开(公告)号：US11464760B2

公开(公告)日：2022-10-11

申请号：US16772776

申请日：2018-12-13

Applicant: LTS Lohmann Therapie-Systeme AG

Inventor： Michael Linn ,  Christoph Schmitz ,  Hanshermann Franke

IPC: A61K31/4045 ,  A61K9/00 ,  A61K9/70 ,  A61K31/404 ,  A61K31/422 ,  A61K31/454 ,  A61K47/12 ,  A61K47/32

Abstract: The present invention relates to frigostable compositions suitable for iontophoretic transdermal delivery of a triptan compound that includes: a salt of a triptan compound, preferably sumatriptan succinate, a polyamine, one or more dicarboxylic acids, 0.5 to 10.0 wt.-% (based on the total weight of the composition) of one or more monocarboxylic acids, and water or an aqueous solvent mixture. The invention further relates to the use of the composition as an integral component of an iontophoretic patch, preferably as an anodic reservoir of the patch.

公开(公告)号：US20230165805A1

公开(公告)日：2023-06-01

申请号：US17900616

申请日：2022-08-31

Applicant: LTS LOHMANN THERAPIE-SYSTEME AG

Inventor： Markus Müller ,  Mario Ficker ,  Michael Linn ,  Florian Hammes

IPC: A61K9/70 ,  A61K31/135 ,  A61K47/32

CPC classification number: A61K9/7007 ,  A61K31/135 ,  A61K47/32

Abstract: Described is an oral thin film comprising at least one matrix layer, wherein the at least one matrix layer comprises at least one pharmaceutically active agent, at least one polyvinyl alcohol and at least one polyvinyl alcohol-polyethylene glycol graft copolymer, a method for producing same, and use thereof as a medicament.

公开(公告)号：US11547677B2

公开(公告)日：2023-01-10

申请号：US16490684

申请日：2018-02-28

Applicant: LTS LOHMANN THERAPIE-SYSTEME AG ,  SANTHERA PHARMACEUTICALS (SCHWEIZ) AG

Inventor： Michael Linn ,  Markus Muller ,  Marius Bauer

IPC: A61K31/22 ,  A61K9/113 ,  A61K47/38 ,  A61K47/32 ,  A61K47/12 ,  A61K47/14 ,  A61K47/22 ,  A61K47/10 ,  A61K47/34 ,  A61K9/00 ,  A61K31/122

Abstract: The invention relates to a transmucosal delivery system for idebenone, comprising an external phase, which contains at least one hydrophilic polymer, and an inner hydrophobic phase, which contains idebenone and at least one hydrophobic substance, wherein the inner hydrophobic phase is emulsified in the form of droplets in the external phase. The invention is characterized in that the inner hydrophobic phase is stabilized by at least one emulsifier in the external phase. The invention also relates to a method for producing the same and its use as a medicament.

公开(公告)号：US10926941B2

公开(公告)日：2021-02-23

申请号：US16162825

申请日：2018-10-17

Applicant: LTS LOHMANN THERAPIE-SYSTEME AG

Inventor： Marc Blomenkemper ,  Michael Linn ,  Ronald Hackbarth ,  Markus Bee

IPC: B65D83/08 ,  A61J7/00

Abstract: A device for dispensing active ingredient-containing or active ingredient-carrying strips, including a housing in which a coil chamber for receiving an active ingredient-containing or active ingredient-carrying band is arranged, in which a gear transmission with a driven roller for conveying the band is mounted, and in which a separating device for separating the strips from the band is arranged. A method for dispensing active ingredient-containing or active ingredient carrying strips using such a device is also disclosed. An active ingredient-containing or active ingredient-carrying band is arranged between the driven roller and the pressure roller. A shift clutch transmission having a manually actuatable trigger element is arranged upstream of the gear transmission. The driven roller can be driven in incremental strips by the shift clutch transmission. A device and method is disclosed for dispensing active ingredient-containing or active ingredient-carrying strips with a largely equal dosage are developed.