公开(公告)号：US20210186826A1

公开(公告)日：2021-06-24

申请号：US17252241

申请日：2019-06-25

申请人： Laclede, Inc.

发明人： Michael Pellico

IPC分类号： A61K8/02 ,  A45D44/00 ,  A61K8/04 ,  A61K8/25 ,  A61K8/34 ,  A61K8/73 ,  A61K8/9717 ,  A61K8/92 ,  A61K8/9789 ,  A61Q19/00 ,  A61K8/65 ,  A61K8/67

摘要： Methods, compositions and devices for customizing a cosmetic mask for application to an individual, the cosmetic mask comprising a gel-like formulation that, when heated, can be customized for specific application to the individual. The invention further provides for a semi-solid starting formulation comprising a solvent, a humectant, a thickener, an acid, water and an effective amount of agar, wherein the semi-solid starting formulation forms a hydrogel when heated. Specifically, the semi-solid starting formulation, once heated, is applied to the skin of an individual while still warm, then forming a gel-like material once the formulation is allowed to fully cool on the skin.

公开(公告)号：US20170128547A1

公开(公告)日：2017-05-11

申请号：US15367072

申请日：2016-12-01

申请人： Laclede, Inc.

发明人： Michael Pellico

IPC分类号： A61K38/47 ,  A61K9/00 ,  A61K31/573 ,  A61K47/38 ,  A61K45/06 ,  A61K47/06 ,  A61K47/10 ,  A61K38/44 ,  A61K38/40

CPC分类号： A61K38/47 ,  A61K9/0046 ,  A61K9/0053 ,  A61K31/573 ,  A61K31/58 ,  A61K38/40 ,  A61K38/44 ,  A61K38/443 ,  A61K45/06 ,  A61K47/06 ,  A61K47/10 ,  A61K47/38 ,  C12Y101/03004 ,  C12Y111/01007 ,  C12Y302/01004 ,  C12Y302/01008 ,  C12Y302/01017 ,  C12Y302/01022 ,  A61K2300/00

摘要： A composition for removal of biofilm in the ears is useful for the treatment of ear infections such as otitis media, particularly those infections caused by Pseudomonas aeruginosa. In general, the composition comprises: (1) a quantity of at least one enzyme that catalyzes the hydrolysis of a bond that connects two monosaccharides in a polysaccharide or that connects a monosaccharide with a protein molecule in a glycoprotein sufficient to break down biofilm in the ear; and (2) a pharmaceutically acceptable carrier suitable for administration into the ear canal. The composition can further include ingredients such as a steroid, lysozyme, lactoferrin, or a peroxidase; if a peroxidase is included, the composition can further include an oxidase to generate peroxide as well as a substrate for the oxidase. The composition can be used in methods for treatment of an ear infection based on the ability of the composition to dissolve biofilm in the ear.

公开(公告)号：US20160279205A1

公开(公告)日：2016-09-29

申请号：US15151076

申请日：2016-05-10

申请人： Laclede, Inc.

发明人： Michael Pellico ,  Pamela Bosco

IPC分类号： A61K38/44 ,  A61K47/26 ,  A61K47/12 ,  A61K47/02 ,  A61K38/40 ,  A61K31/573 ,  A61K9/00 ,  A61K47/10 ,  A61K31/375 ,  A61K38/47

CPC分类号： A61K38/44 ,  A61K9/007 ,  A61K31/375 ,  A61K31/573 ,  A61K38/40 ,  A61K38/443 ,  A61K38/47 ,  A61K45/06 ,  A61K47/02 ,  A61K47/10 ,  A61K47/12 ,  A61K47/26 ,  C12Y101/03004 ,  C12Y101/03009 ,  C12Y101/03017 ,  C12Y111/01007 ,  C12Y111/02002 ,  C12Y302/01017 ,  A61K2300/00

摘要： A therapeutic composition for the treatment of lung diseases or disorders and diseases or disorders of the airway passages including pneumonia, acute respiratory failure, and acute respiratory distress syndrome is based on the generation of a biocidal anion by an enzymatic reaction catalyzed by a peroxidase. The peroxide utilized by the peroxidase enzyme can be endogenous or can be generalized by the action of an oxidase enzyme on a suitable substrate.

摘要翻译： 用于治疗肺部疾病或疾病的疾病或疾病或疾病或病症的治疗组合物，包括肺炎，急性呼吸衰竭和急性呼吸窘迫综合征，基于通过由过氧化物酶催化的酶反应产生杀生物阴离子。 过氧化物酶使用的过氧化物可以是内源的，或者可以通过氧化酶在合适的底物上的作用来推广。

公开(公告)号：US20160279206A1

公开(公告)日：2016-09-29

申请号：US15151315

申请日：2016-05-10

申请人： Laclede, Inc.

发明人： Michael Pellico ,  Rajvinder Kaur Atwal

IPC分类号： A61K38/44 ,  A61K31/375 ,  A61K31/19 ,  A61K9/00 ,  A61K47/10

CPC分类号： A61K38/44 ,  A61K9/0034 ,  A61K31/19 ,  A61K31/375 ,  A61K31/573 ,  A61K31/58 ,  A61K33/40 ,  A61K38/40 ,  A61K38/443 ,  A61K38/47 ,  A61K45/06 ,  A61K47/10 ,  A61K47/44 ,  C12Y101/03004 ,  C12Y111/01007 ,  C12Y111/02002 ,  A61K2300/00

摘要： A therapeutic composition for vaginal administration based on the generation of a biocidal anion by an enzymatic reaction catalyzed by a peroxidase. The peroxide utilized by the peroxidase enzyme can be endogenous or can be generated by the action of an oxidase enzyme on a suitable substrate. Therapeutic compositions according to the present invention are useful for the treatment of vaginal diseases and conditions, including bacterial and fungal infections.

摘要翻译： 基于通过过氧化物酶催化的酶反应产生杀生物阴离子的阴道给药治疗组合物。 过氧化物酶使用的过氧化物可以是内源的，或者可以通过氧化酶在合适的底物上的作用而产生。 根据本发明的治疗性组合物可用于治疗阴道疾病和病症，包括细菌和真菌感染。

公开(公告)号：US20240315932A1

公开(公告)日：2024-09-26

申请号：US18439657

申请日：2024-02-12

申请人： Laclede, Inc.

发明人： Michael Pellico

IPC分类号： A61K8/02 ,  A45D44/00 ,  A61K8/04 ,  A61K8/25 ,  A61K8/34 ,  A61K8/73 ,  A61K8/9717 ,  A61Q19/00

CPC分类号： A61K8/0212 ,  A45D44/002 ,  A61K8/0216 ,  A61K8/042 ,  A61K8/25 ,  A61K8/345 ,  A61K8/735 ,  A61K8/9717 ,  A61Q19/00 ,  A45D2200/155 ,  A61K2800/48 ,  A61K2800/80

摘要： Methods, compositions and devices for customizing a cosmetic mask for application to an individual, the cosmetic mask comprising a gel-like formulation that, when heated, can be customized for specific application to the individual. The invention further provides for a semi-solid starting formulation comprising a solvent, a humectant, a thickener, an acid, water and an effective amount of agar, wherein the semi-solid starting formulation forms a hydrogel when heated. Specifically, the semi-solid starting formulation, once heated, is applied to the skin of an individual while still warm, then forming a gel-like material once the formulation is allowed to fully cool on the skin.

公开(公告)号：US10245303B2

公开(公告)日：2019-04-02

申请号：US15151076

申请日：2016-05-10

申请人： Laclede, Inc.

发明人： Michael Pellico ,  Pamela Bosco

IPC分类号： A61K31/573 ,  A61K38/44 ,  A61K38/40 ,  A61K45/06 ,  A61K38/47 ,  A61K9/00 ,  A61K31/375 ,  A61K47/02 ,  A61K47/10 ,  A61K47/12 ,  A61K47/26

摘要： A therapeutic composition for the treatment of lung diseases or disorders and diseases or disorders of the airway passages including pneumonia, acute respiratory failure, and acute respiratory distress syndrome is based on the generation of a biocidal anion by an enzymatic reaction catalyzed by a peroxidase. The peroxide utilized by the peroxidase enzyme can be endogenous or can be generalized by the action of an oxidase enzyme on a suitable substrate.

公开(公告)号：US09993533B2

公开(公告)日：2018-06-12

申请号：US14991571

申请日：2016-01-08

申请人： Laclede, Inc.

发明人： Michael Pellico

IPC分类号： A61K38/40 ,  A61K38/47 ,  A61K38/54 ,  A61K38/44 ,  A61K45/06 ,  A61K31/573 ,  A61K38/46

CPC分类号： A61K38/54 ,  A61K31/573 ,  A61K38/40 ,  A61K38/44 ,  A61K38/443 ,  A61K38/465 ,  A61K38/47 ,  A61K45/06 ,  C12Y111/01007 ,  C12Y302/01 ,  C12Y302/01011 ,  C12Y302/01015 ,  C12Y302/01017 ,  A61K2300/00

摘要： A composition for removal of biofilm in the airway passage is useful for the treatment of infections such as pneumonia cause by Mycoplasma pneumoniae. In general, the composition comprises: (1) a quantity of at least one enzyme that catalyzes the hydrolysis of a bond that connects two monosaccharides in a polysaccharide or that connects a monosaccharide with a protein molecule in a glycoprotein sufficient to break down biofilm in the airway; and (2) a pharmaceutically acceptable carrier suitable for administration into the airway. The composition can further include ingredients such as a steroid, lysozyme, lactoferrin, or a peroxidase; if a peroxidase is included, the composition can further include an oxidase to generate peroxide as well as a substrate for the oxidase. The composition can be used in methods for treatment of an infection based on the ability of the composition to dissolve biofilm in the airway.

公开(公告)号：US20160144004A1

公开(公告)日：2016-05-26

申请号：US14991571

申请日：2016-01-08

申请人： Laclede, Inc.

发明人： Michael Pellico

IPC分类号： A61K38/54 ,  A61K38/40 ,  A61K31/573 ,  A61K38/44 ,  A61K38/47 ,  A61K38/46 ,  A61K45/06

CPC分类号： A61K38/54 ,  A61K31/573 ,  A61K38/40 ,  A61K38/44 ,  A61K38/443 ,  A61K38/465 ,  A61K38/47 ,  A61K45/06 ,  C12Y111/01007 ,  C12Y302/01 ,  C12Y302/01011 ,  C12Y302/01015 ,  C12Y302/01017 ,  A61K2300/00

摘要： A composition for removal of biofilm in the airway passage is useful for the treatment of infections such as pneumonia cause by Mycoplasma pneumoniae. In general, the composition comprises: (1) a quantity of at least one enzyme that catalyzes the hydrolysis of a bond that connects two monosaccharides in a polysaccharide or that connects a monosaccharide with a protein molecule in a glycoprotein sufficient to break down biofilm in the airway; and (2) a pharmaceutically acceptable carrier suitable for administration into the airway. The composition can further include ingredients such as a steroid, lysozyme, lactoferrin, or a peroxidase; if a peroxidase is included, the composition can further include an oxidase to generate peroxide as well as a substrate for the oxidase. The composition can be used in methods for treatment of an infection based on the ability of the composition to dissolve biofilm in the airway.

摘要翻译： 用于在气道通道中去除生物膜的组合物可用于治疗由肺炎支原体引起的肺炎等感染。 通常，组合物包含：（1）一定量的至少一种酶，其催化连接多糖中的两个单糖的键的水解，或者连接单糖与蛋白质分子在足以分解生物膜中的蛋白质分子 气道 和（2）适于施用于气道的药学上可接受的载体。 该组合物还可以包括成分如类固醇，溶菌酶，乳铁蛋白或过氧化物酶; 如果包括过氧化物酶，组合物还可以包括氧化酶以产生过氧化物以及用于氧化酶的底物。 该组合物可用于基于组合物在气道中溶解生物膜的能力来治疗感染的方法。