公开(公告)号：US20200330544A1

公开(公告)日：2020-10-22

申请号：US16756757

申请日：2018-10-16

申请人： LAILA NUTRACEUTICALS ,  P.L. THOMAS-LAILA NUTRACEUTICALS, INC.

发明人： Ganga Raju GOKARAJU ,  Rama Raju GOKARAJU ,  Trimurtulu GOLAKOTI ,  Venkateswara Rao CHIRRAVURI ,  Venkateswarlu SOMEPALLI ,  Kiran BHUPATHIRAJU

IPC分类号： A61K36/9066 ,  A61K36/75 ,  A23L33/105

摘要： Synergistic herbal compositions comprising combination of extracts, fractions or phytochemicals or mixtures thereof derived from Moringa oleifera, Murraya koenigii and Curcuma longa for increasing lean body mass and brown adipose tissue; for accelerating the conversion of the white adipose tissue (WAT) to brown adipose tissue (BAT), inhibiting excessive generation of advanced glycation end (AGE) products and disease conditions associated with increased levels of advanced glycation end (AGE) products. The invention further provides a method of increasing lean body mass and brown adipose tissue; accelerating the conversion of the white adipose tissue (WAT) to brown adipose tissue (BAT), inhibiting excessive generation of advanced glycation end (AGE) products and disease conditions associated with increased levels of advanced glycation end (AGE) products in mammals.

公开(公告)号：US20210338757A1

公开(公告)日：2021-11-04

申请号：US16479798

申请日：2017-01-19

申请人： LAILA NUTRACEUTICALS

发明人： Ganga Raju GOKARAJU ,  Rama Raju GOKARAJU ,  Trimurtulu GOLAKOTI ,  Kiran BHUPATHIRAJU ,  Venkata Kanaka Ranga Raju GOKARAJU ,  Krishanu SENGUPTHA ,  Venkata Krishna Raju ALLURI

IPC分类号： A61K36/22 ,  A61K36/38 ,  A61K45/06 ,  A23L33/105 ,  A61K9/00 ,  A61P15/10

摘要： The invention discloses synergistic compositions comprising extracts, fractions or pure compounds derived from at least two herbs selected from Punica granatum, Mangifera indica and Garcinia mangostana for inhibiting the expression/production/activity of Phosphodiesterase 5 (PDE5) enzyme or for increasing cGMP levels in a male subject. The invention further discloses a method of inhibiting the expression/production/activity of Phosphodiesterase 5 (PDE5) enzyme, increasing cGMP levels and sexual arousal, treating/alleviating various aspects of male sexual dysfunction or impotence such as erectile dysfunction, loss of libido, or orgasm/ejaculation disorders in a male subject by using a suitable dose of synergistic composition comprising extracts, fractions or pure compounds derived from at least two herbs selected from Punica granatum, Mangifera indica and Garcinia mangostana.

公开(公告)号：US20210138014A1

公开(公告)日：2021-05-13

申请号：US16492473

申请日：2018-03-08

申请人： LAILA NUTRACEUTICALS

发明人： Ganga Raju GOKARAJU ,  Rama Raju GOKARAJU ,  Trimurtulu GOLAKOTI ,  Kiran BHUPATHIRAJU ,  Venkata Kanaka Ranga Raju GOKARAJU ,  Krishanu SENGUPTHA ,  Venkata Krishna Raju ALLURI ,  Venkateswarlu SOMEPALLI

IPC分类号： A61K36/54 ,  A61K36/22 ,  A61K36/31 ,  A61K36/71 ,  A61K36/8962

摘要： Synergistic herbal compositions for Testosterone boosting comprising at least two ingredients selected from the extracts, fractions or pure phytochemicals derived from Punica granatum, Cinnamomum zeylanicum, Nigella sativa, Brassica nigra and Mangifera indica for improving testosterone levels and alleviating symptoms associated with low levels of testosterone hormone in humans. The present invention also describes a synergistic composition comprising at least one testosterone booster ingredient selected from the extracts, fractions or pure phytochemical derived from Punica granatum, Cinnamomum zeylanicum, Nigella sativa, Brassica nigra and Mangifera indica and at least one aromatase inhibitor ingredient selected from the extracts, fractions or pure phytochemicals derived from Allium cepa, Tamarindus indica and Cinnamomum tamala for improving testosterone levels and alleviating symptoms associated with low levels of testosterone hormone in humans. The invention further provides methods of improving testosterone levels and alleviating symptoms associated with low levels of testosterone hormone in humans.

公开(公告)号：US20230241152A1

公开(公告)日：2023-08-03

申请号：US18000146

申请日：2021-05-29

申请人： LAILA NUTRACEUTICALS

发明人： Ganga Raju GOKARAJU ,  Rama Raju Gokaraju ,  Kiran BHUPATHIRAJU ,  Venkata Kanaka Ranga Raju GOKARAJU ,  Trimurtulu GOLAKOTI ,  Krishanu SENGUPTHA ,  Venkateswarlu SOMEPALLI ,  Venkata Krishna Raju ALLURI

IPC分类号： A61K36/888 ,  A23L33/00 ,  A23L33/105 ,  A61K36/185 ,  A61K36/81 ,  A61P1/14

CPC分类号： A61K36/888 ,  A23L33/40 ,  A23L33/105 ,  A61K36/185 ,  A61K36/81 ,  A61P1/14 ,  A61K2236/331 ,  A61K2236/333

摘要： Synergistic Herbal Compositions For Improving Gut Health” The present invention discloses synergistic herbal compositions comprising at least two ingredients selected from extract(s), fraction(s), phytochemical(s), or mixtures thereof derived each one from a different herb selected from Abelmoschus esculentus, Withania somnifera and Amorphophallus paeoniifolius; improving at least one gut health function selected from gut-brain axis, easing of constipation, bowel movement, improved GI motility, digestion and gut immunity; and reducing gut inflammation. The invention further relates to methods of treatment and the use of the compositions.

公开(公告)号：US20130136809A1

公开(公告)日：2013-05-30

申请号：US13752181

申请日：2013-01-28

申请人： LAILA NUTRACEUTICALS

发明人： Ganga Raju GOKARAJU ,  Rama Raju GOKARAJU ,  Venkata Kanaka Ranga Raju GOKARAJU ,  Trimurtulu GOLAKOTI ,  Kiran BHUPATHIRAJU ,  Krishanu SENGUPTA

IPC分类号： A61K31/5377 ,  A61K31/437 ,  A61K31/19 ,  A61K31/365 ,  A61K45/06

CPC分类号： A61K31/365 ,  A23L33/105 ,  A23V2002/00 ,  A61K31/19 ,  A61K31/352 ,  A61K31/437 ,  A61K31/5377 ,  A61K35/12 ,  A61K36/28 ,  A61K36/38 ,  A61K45/06 ,  A61K2300/00 ,  A23V2250/21

摘要： The invention discloses biologically active ingredient(s) selected from 7-hydroxyfrullanolide, its analogs, the ex-tract(s) and fraction(s) standardized to 7-hydroxyfrullanolide or its analogs or both or mixtures thereof or their composition(s) for the prevention, control and treatment of one or more obesity, overweight, metabolic syndrome, diabetes and other metabolic disorders or for producing lean body mass in a warm blooded animal in need thereof.

摘要翻译： 本发明公开了生物活性成分，其选自7-羟基富勒烯内酯，其类似物，标准化为7-羟基果糖内酯的前体和级分或其类似物或两者或其混合物或其组合物， 预防，控制和治疗一种或多种肥胖，超重，代谢综合征，糖尿病和其他代谢紊乱，或用于在有需要的温血动物中产生瘦体重。

公开(公告)号：US20220143124A1

公开(公告)日：2022-05-12

申请号：US17600793

申请日：2020-04-01

申请人： LAILA NUTRACEUTICALS

发明人： Ganga Raju GOKARAJU ,  Rama Raju GOKARAJU ,  Venkata Kanaka Ranga Raju GOKARAJU ,  Trimurtulu GOLAKOTI ,  Kiran BHUPATHIEAJU ,  Krishanu SENGUPTHA ,  Vankata Krishna Raju ALLURI ,  Venkateswarlu SOMEPALLI

IPC分类号： A61K36/75 ,  A61K36/23 ,  A61K36/9066 ,  A61P19/02

摘要： Disclosed herein is Synergistic herbal composition(s) comprising combination of a first ingredient selected from the extract(s), fraction(s), phytochemical(s) and mixtures thereof derived from Murraya koenigii and a second ingredient selected from the extract(s), fraction(s), phytochemical(s) and mixtures thereof derived from Coriandrum sativum or Curcuma amada for improving cartilage growth/repair/regeneration, improving joint mobility, reducing cartilage breakdown, reducing joint pain, reducing stiffness, reducing inflammation and/or treating/alleviating symptoms associated with osteoarthritis. The invention further provides method of improving cartilage growth/repair/regeneration, improving joint mobility, reducing cartilage breakdown, reducing joint pain, reducing stiffness, reducing inflammation and/or treating/alleviating symptoms associated with osteoarthritis in a human or animal.

公开(公告)号：US20190201470A1

公开(公告)日：2019-07-04

申请号：US16312150

申请日：2017-06-21

申请人： LAILA NUTRACEUTICALS

发明人： Ganga Raju GOKARAJU ,  Rama Raju GOKARAJU ,  Kishore Babu GOVADA ,  Venkata Krishna Raju ALLURI ,  Nagendra Babu VUTTI ,  Kiran BHUPATHIRAJU ,  Venkata Kanaka Ranga Raju GOKARAJU ,  Trimurtulu GOLAKOTI

IPC分类号： A61K36/68 ,  A61K47/32 ,  A61K47/44 ,  A61K47/36 ,  A61K9/16 ,  A23L27/00 ,  A23L33/105

CPC分类号： A61K36/68 ,  A23L27/84 ,  A23L33/105 ,  A23V2002/00 ,  A23V2200/16 ,  A23V2300/31 ,  A23V2300/40 ,  A61K9/1635 ,  A61K31/7048 ,  A61K36/19 ,  A61K36/22 ,  A61K36/324 ,  A61K36/38 ,  A61K36/42 ,  A61K36/58 ,  A61K36/81 ,  A61K47/32 ,  A61K47/36 ,  A61K47/44 ,  A61K2300/00

摘要： The invention discloses taste masking formulations for bitter natural compounds, selected from the extracts, fraction and pure phytochemicals produced in combination with a synthetic polymer or a natural polymer. The invention also relates to the novel process of producing the taste masking formulations. The invention also relates to taste masking formulations of Bacopa extracts with no bitter taste or negligible bitter taste in combination with synthetic polymers such as Eudragit or natural polymers such as Shellac.

公开(公告)号：US20190192607A1

公开(公告)日：2019-06-27

申请号：US16331370

申请日：2017-09-08

申请人： LAILA NUTRACEUTICALS

发明人： Ganga Raju GOKARAJU ,  Rama Raju GOKARAJU ,  Kishore Babu GOVADA ,  Venkata Krishna Raju ALLURI ,  Nagendra Babu VUTTI ,  Kiran BHUPATHIRAJU ,  Venkata Kanaka Ranga Raju GOKARAJU ,  Trimurtulu GOLAKOTI

IPC分类号： A61K36/84 ,  A61K47/38 ,  A61K9/00 ,  A61K9/14 ,  A23L27/00 ,  A23L29/288

CPC分类号： A61K36/84 ,  A23L27/86 ,  A23L29/288 ,  A23V2002/00 ,  A23V2250/21 ,  A23V2300/10 ,  A23V2300/31 ,  A61K9/0056 ,  A61K9/146 ,  A61K47/38

摘要： The invention discloses odor masking formulations for stench natural compounds, selected from the extracts, fraction and pure phytochemicals that are produced in combination with a natural or synthetic hydrocolloid polymer gum(s). The invention further discloses novel process of producing the odor and taste masking formulations. The invention also discloses taste masking formulations of valerian extracts with no characteristic stench odor & or negligible stench odor in combination with natural hydrocolloid gum such as guar gum, acacia or other polymers. The invention further discloses method of reducing insomnia, anxiety, Attention Deficit Disorder (ADD), Chronic Fatigue Syndrome (CFS) using odor masking formulation of the current invention. Importantly, the said odor masked formulation of the present disclosure helps in improving sleep cycle and helps in efficient functioning of brain.

公开(公告)号：US20150290270A1

公开(公告)日：2015-10-15

申请号：US14735360

申请日：2015-06-10

申请人： LAILA NUTRACEUTICALS

发明人： Ganga Raju GOKARAJU ,  Rama Raju GOKARAJU ,  Venkata Kanaka Ranga Raju GOKARAJU ,  Trimurtulu GOLAKOTI ,  Kiran BHUPATHIRAJU ,  Venkata Krishna Raju ALLURI

IPC分类号： A61K36/324

CPC分类号： A61K36/324

摘要： The present invention discloses synergistic nutraceutical or pharmaceutical or dietary supplement anti-inflammatory compositions comprising therapeutically effective combination of an extract selectively enriched in 3-O-acetyl-1 1-keto-β-boswellic acid (AKBA) derived from Boswellia serrata and Boswellia serrata non-acidic resin extract (BNRE). The composition(s) can be used to prevent, control and treat inflammation and several inflammatory related diseases including asthma, osteoarthritis, rheumatoid arthritis, endothelial dysfunction and the like. The invention further discloses the amelioration of pro-inflammatory biomarker proteins or molecules, whose expression/production is altered during inflammatory diseases.

摘要翻译： 本发明公开了协同营养药物或药物或膳食补充剂抗炎组合物，其包含选自富含源于乳香乳杆菌（Boswellia serrata）和乳香型乳杆菌（Boswellia）的3-O-乙酰基-11-酮基 - 巴豆威酸（AKBA） 锯齿酸非酸性树脂提取物（BNRE）。 组合物可用于预防，控制和治疗炎症和若干炎性相关疾病，包括哮喘，骨关节炎，类风湿性关节炎，内皮功能障碍等。 本发明还公开了在炎性疾病期间其表达/产生被改变的促炎生物标记蛋白或分子的改善。

公开(公告)号：US20230346736A1

公开(公告)日：2023-11-02

申请号：US18012411

申请日：2021-06-23

申请人： LAILA NUTRACEUTICALS

发明人： Ganga Raju GOKARAJU ,  Rama Raju GOKARAJU ,  Trimurtulu GOLAKOTI ,  Venkata Kanaka Ranga Raju GOKARAJU ,  Kiran BHUPATHIRAJU ,  Venkata Krishna Raju ALLURI ,  Venkateswarlu SOMEPALLI ,  Krishanu SENGUPTHA

IPC分类号： A61K31/22 ,  A61P21/00 ,  A61K33/00

CPC分类号： A61K31/22 ,  A61K33/00 ,  A61P21/00

摘要： The present invention discloses water-soluble 3-O-acetyl-11-keto-β-boswellic acid compositions comprising 3-O-acetyl-11-keto-β-boswellic acid in combination with a metal ion selected from potassium or sodium in the form of respective metal salt or complex or chelate; process for their preparation; methods of prevention, control and/or treatment of at least one disorder selected from muscle soreness, delayed-onset of muscle soreness (DOMS), muscles tenderness, muscle pain, muscle fatigue, muscle sprain, temporary loss of muscle strength and swelling in muscles.