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    Novel biomaterials their preparation and use
    1.
    发明申请
    Novel biomaterials their preparation and use 审中-公开
    新型生物材料的制备和使用

    公开(公告)号：US20050163853A1

    公开(公告)日：2005-07-28

    申请号：US10511075

    申请日：2003-04-17

    申请人： Lajos Szente ,  Jozsef Szejtli ,  Gyorgy Kis ,  Christian Schoch

    发明人： Lajos Szente ,  Jozsef Szejtli ,  Gyorgy Kis ,  Christian Schoch

    IPC分类号： A61K47/48 ,  A23L35/00 ,  A61K9/00 ,  A61K9/12 ,  A61K9/20 ,  A61K9/70 ,  A61K47/18 ,  A61K47/36 ,  A61K47/40 ,  A61L27/20 ,  A61L27/54 ,  C08L101/16 ,  A61K9/14 ,  A01N43/04 ,  A61K31/724

    CPC分类号： A61K9/0024 ,  A61K9/7015 ,  A61L27/20 ,  A61L27/54 ,  A61L2300/602 ,  A61L2300/802 ,  C08L5/16

    摘要： The present invention relates to novel materials, particularly biomaterials, in form of a precipitate, comprising at least an anonic polymeric component which is as such soluble in water and an amphiphilic ammonium-type component, which precipitate is obtainable by a process including the following steps: contacting the anionic polymeric component and an cylcodextrin component in an aqueous medium, and adding to the mixture obtained in step 1 said amphiphilic ammonium-type component, wherein said component are present in amounts effective to form said precipitate, and preferably to corresponding precipitates additionally comprising said cycxlodextrin component. Both types of precipitates may optionally comprise one or more further components. The precipitates are particularly useful as controlled-release depot formulations suitable for long-lasting delivery of said further components. The further components incorporated into the precipitates can be pharmaceutical compounds, pesticides, agrochemicals, colorants, diagnostics, enzymes, foodstuffs etc.

    摘要翻译： 本发明涉及沉淀形式的新型材料，特别是生物材料，其包含至少一种如此可溶于水的阳离子聚合物组分和两亲性铵型组分，所述沉淀物可通过包括以下步骤 ：将水性介质中的阴离子聚合物组分和环糊精组分接触，并向步骤1中获得的混合物中加入所述两亲性铵型组分，其中所述组分以有效形成所述沉淀物的量存在，优选以相应的沉淀物 包括所述环糊精组分。 两种类型的沉淀物可任选地包含一种或多种另外的组分。 沉淀物特别适用于适用于持久递送所述其它组分的控释剂型剂型。 掺入沉淀物中的其它组分可以是药物化合物，农药，农药，着色剂，诊断，酶，食品等。

    NOVEL BIOMATERIALS, THEIR PREPARATION AND USE
    2.
    发明申请
    NOVEL BIOMATERIALS, THEIR PREPARATION AND USE 审中-公开
    新生物材料，其制备和使用

    公开(公告)号：US20080299166A1

    公开(公告)日：2008-12-04

    申请号：US12178934

    申请日：2008-07-24

    申请人： Lajos Szente ,  Jozsef Szejtli ,  Gyorgy L. Kis ,  Christian Schoch

    发明人： Lajos Szente ,  Jozsef Szejtli ,  Gyorgy L. Kis ,  Christian Schoch

    IPC分类号： A61K47/30 ,  A61K47/40 ,  A61F2/00 ,  A61K38/02 ,  A61P17/02 ,  A61K31/56 ,  A61K38/43

    CPC分类号： A61K9/0024 ,  A61K9/7015 ,  A61L27/20 ,  A61L27/54 ,  A61L2300/602 ,  A61L2300/802 ,  C08L5/16

    摘要： The present invention relates to novel materials, particularly biomaterials, in form of a precipitate, comprising at least an anionic polymeric component which is as such soluble in water and an amphiphilic ammonium-type component, which precipitate is obtainable by a process including the following steps: 1. contacting the anionic polymeric component and an cyclodextrin component in an aqueous medium, and 2. adding to the mixture obtained in step 1 said amphiphilic ammonium-type component, wherein said components are present in amounts effective to form said precipitate, and preferably to corresponding precipitates additionally comprising said cyclodextrin component. Both types of precipitates may optionally comprise one or more further components. The precipitates are particularly useful as controlled-release depot formulations suitable for long-lasting delivery of said further components. The further components incorporated into the precipitates can be pharmaceutical compounds, pesticides, agrochemicals, colorants, diagnostics, enzymes, foodstuffs etc.

    摘要翻译： 本发明涉及沉淀物形式的新型材料，特别是生物材料，其包含至少一种如此可溶于水的阴离子聚合物组分和两亲性铵型组分，所述沉淀物可通过包括以下步骤 1.将阴离子聚合物组分和环糊精组分在水性介质中接触，2.向步骤1中获得的混合物中加入所述两亲性铵型组分，其中所述组分以有效形成所述沉淀物的量存在，优选 到另外包含所述环糊精组分的相应沉淀物。 两种类型的沉淀物可任选地包含一种或多种另外的组分。 沉淀物特别适用于适用于持久递送所述其它组分的控释剂型剂型。 掺入沉淀物中的其它组分可以是药物化合物，农药，农药，着色剂，诊断，酶，食品等。

    NOVEL BIOMATERIALS, THEIR PREPARATION AND USE
    3.
    发明申请
    NOVEL BIOMATERIALS, THEIR PREPARATION AND USE 审中-公开
    新生物材料，其制备和使用

    公开(公告)号：US20120040901A1

    公开(公告)日：2012-02-16

    申请号：US13281033

    申请日：2011-10-25

    申请人： Lajos Szente ,  Jozsef Szejtli ,  György Lajos Kis ,  Christian Schoch

    发明人： Lajos Szente ,  Jozsef Szejtli ,  György Lajos Kis ,  Christian Schoch

    IPC分类号： A61K38/22 ,  C12N9/00 ,  A61K31/4535 ,  A23L1/48 ,  A61K31/568 ,  A61K31/5575 ,  A61P43/00 ,  A01P15/00 ,  A01N25/00 ,  A61K31/12

    CPC分类号： A61K9/0024 ,  A61K9/7015 ,  A61L27/20 ,  A61L27/54 ,  A61L2300/602 ,  A61L2300/802 ,  C08L5/16

    摘要： The present invention relates to novel materials, particularly biomaterials, in form of a precipitate, comprising at least an anionic polymeric component which is as such soluble in water and an amphiphilic ammonium-type component, which precipitate is obtainable by a process including the following steps: 1. contacting the anionic polymeric component and an cyclodextrin component in an aqueous medium, and 2. adding to the mixture obtained in step 1 said amphiphilic ammonium-type component, wherein said components are present in amounts effective to form said precipitate, and preferably to corresponding precipitates additionally comprising said cyclodextrin component. Both types of precipitates may optionally comprise one or more further components. The precipitates are particularly useful as controlled-release depot formulations suitable for long-lasting delivery of said further components. The further components incorporated into the precipitates can be pharmaceutical compounds, pesticides, agrochemicals, colorants, diagnostics, enzymes, foodstuffs etc.

    摘要翻译： 本发明涉及沉淀物形式的新型材料，特别是生物材料，其包含至少一种如此可溶于水的阴离子聚合物组分和两亲性铵型组分，所述沉淀物可通过包括以下步骤 1.将阴离子聚合物组分和环糊精组分在水性介质中接触，2.向步骤1中获得的混合物中加入所述两亲性铵型组分，其中所述组分以有效形成所述沉淀物的量存在，优选 到另外包含所述环糊精组分的相应沉淀物。 两种类型的沉淀物可任选地包含一种或多种另外的组分。 沉淀物特别适用于适用于持久递送所述其它组分的控释剂型剂型。 掺入沉淀物中的其它组分可以是药物化合物，农药，农药，着色剂，诊断，酶，食品等。

    Quaternised Ammonium Cyclodextrin Compounds
    7.
    发明申请
    Quaternised Ammonium Cyclodextrin Compounds 审中-公开
    季铵化环糊精化合物

    公开(公告)号：US20120004158A1

    公开(公告)日：2012-01-05

    申请号：US13234912

    申请日：2011-09-16

    申请人： Georg Ludwig Kis ,  Christian Schoch ,  Jozsef Szejtli

    发明人： Georg Ludwig Kis ,  Christian Schoch ,  Jozsef Szejtli

    IPC分类号： A61K38/00 ,  A61P31/04 ,  A61K31/711 ,  A61P31/10 ,  A61K31/7105 ,  A61K31/715 ,  A61P31/00

    CPC分类号： A61K31/724 ,  A61K31/196 ,  A61K31/4535 ,  C08B37/0012

    摘要： Use of a compound of formula (I): wherein the symbol cyclodextrin ]n represents a n-valent residue derived from a cyclodextrin compound by removing n of its hydroxyl groups; n is a number greater than 0 and represents the average number of substituents of formula per molecule of said compound; h is 0 or 1; R1 is a di-valent group selected from alkylene, hydroxy alkylene, halogeno alkylene, monocyclic aralkylene, cycloalkylene and phenylene; R2, R3 and R4 are each independently of one another a group selected from alkyl, cycloalkyl, aryl, aralkyl, and cycloheteryl; Xm− is a m-fold negatively charged anion; m is an integer being equal or greater than 1; and k is n/m in the preparation of an anti-infective medicament, as preservative and penetration enhancer.

    摘要翻译： 式（I）化合物的用途：其中符号环糊精] n表示通过除去其羟基而衍生自环糊精化合物的n价残基; n是大于0的数，表示每分子所述化合物的式的取代基的平均数; h为0或1; R1是选自亚烷基，羟基亚烷基，卤代亚烷基，单环亚芳基，亚环烷基和亚苯基的二价基团; R2，R3和R4各自独立地为选自烷基，环烷基，芳基，芳烷基和环戊基的基团; Xm-是一个m-带负电荷的阴离子; m是等于或大于1的整数; 在制备抗感染药物中，k为n / m，作为防腐剂和渗透促进剂。

    QUATERNISED AMMONIUM CYCLODEXTRIN COMPOUNDS
    8.
    发明申请
    QUATERNISED AMMONIUM CYCLODEXTRIN COMPOUNDS 审中-公开
    季铵化合物CYCLODEXTRIN化合物

    公开(公告)号：US20090110734A1

    公开(公告)日：2009-04-30

    申请号：US12238473

    申请日：2008-09-26

    申请人： Georg Ludwig Kis ,  Christian Schoch ,  Jozsef Szejtli

    发明人： Georg Ludwig Kis ,  Christian Schoch ,  Jozsef Szejtli

    IPC分类号： A61K9/10 ,  C07H15/04 ,  A61K31/7028 ,  A61K38/02

    CPC分类号： A61K31/724 ,  A61K31/196 ,  A61K31/4535 ,  C08B37/0012

    摘要： Use of a compound of formula (I): wherein the symbol represents a n-valent residue derived from a cyclodextrin compound by removing n of its hydroxyl groups; n is a number greater than 0 and represents the average number of substituents of formula per molecule of said compound; h is 0 or 1; R1 is a di-valent group selected from alkylene, hydroxy alkylene, halogeno alkylene, monocyclic aralkylene, cycloalkylene and phenylene; R2, R3 and R4 are each independently of one another a group selected from alkyl, cycloalkyl, aryl, aralkyl, and cycloheteryl; xm− is a m-fold negatively charged anion; m is an integer being equal or greater than 1; and k is n/m in the preparation of an anti-infective medicament, as preservative and penetration enhancer.

    摘要翻译： 式（I）化合物的用途：其中符号表示通过除去其羟基而衍生自环糊精化合物的n价残基; n是大于0的数，表示每分子所述化合物的式的取代基的平均数; h为0或1; R1是选自亚烷基，羟基亚烷基，卤代亚烷基，单环亚芳基，亚环烷基和亚苯基的二价基团; R2，R3和R4各自独立地为选自烷基，环烷基，芳基，芳烷基和环戊基的基团; xm-是m-带负电荷的阴离子; m是等于或大于1的整数; 在制备抗感染药物中，k为n / m，作为防腐剂和渗透促进剂。

    Quaternised ammonium cyclodextrin compounds
    9.
    发明申请
    Quaternised ammonium cyclodextrin compounds 审中-公开
    季铵化的环糊精化合物

    公开(公告)号：US20050222085A1

    公开(公告)日：2005-10-06

    申请号：US10516247

    申请日：2003-06-12

    申请人： Georg Kis ,  Christian Schoch ,  Jozsef Szejtli

    发明人： Georg Kis ,  Christian Schoch ,  Jozsef Szejtli

    IPC分类号： A61K47/30 ,  A61K31/724 ,  A61K45/00 ,  A61K47/32 ,  A61K47/34 ,  A61K47/36 ,  A61K47/38 ,  A61K47/40 ,  A61P17/00 ,  A61P27/02 ,  A61P31/00 ,  A61P31/04 ,  C08B37/16

    CPC分类号： A61K31/724 ,  A61K31/196 ,  A61K31/4535 ,  C08B37/0012

    摘要： Use of a compound of formula (I), wherein the symbol (a) represents a n-valent residue derived from a cyclodextrin compound by removing n of its hydroxyl groups; n is a number greater than 0 and represents the average number of substituents of formula (II) per molecule of said compound; h is 0 or 1; R1 is a di-valent group selected from alkylene, hydroxy alkylene, halogeno alkylene, monocyclic aralkylene, cycloalkylene and phenylene; R2, R3 and R4 are each independently of one another a group selected from alkyl, cycloalkyl, aryl, aralkyl and cycloheteryl; Xm− is a m-fold negatively charged anion; m is an integer being equal or greater than 1; and k is n/m in the preparation of an anti-infective medicament, as preservative and penetration enhancer.

    摘要翻译： 式（I）化合物的用途，其中符号（a）表示通过除去其羟基而衍生自环糊精化合物的n价残基; n是大于0的数，表示每分子所述化合物的式（II）的取代基的平均数; h为0或1; R 1是选自亚烷基，羟基亚烷基，卤代亚烷基，单环亚芳基，亚环烷基和亚苯基的二价基团; R 2，R 3和R 4各自彼此独立地为选自烷基，环烷基，芳基，芳烷基和环戊基的基团。 X-m - 是一个带负电荷的m倍的阴离子; m是等于或大于1的整数; 在制备抗感染药物中，k为n / m，作为防腐剂和渗透促进剂。