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1.发明授权Modified clostridial toxins with enhanced targeting capabilities for endogenous clostridial toxin receptor systems 有权改良的梭菌毒素具有增强的内源性梭菌毒素受体系统的靶向能力公开(公告)号：US08128940B2
公开(公告)日：2012-03-06
申请号：US11908349
申请日：2006-03-14
申请人： Lance E. Steward , Ester Fernandez-Salas , Joseph Francis , Shengwen Li , Marcella A. Gilmore , Kei R. Aoki
发明人： Lance E. Steward , Ester Fernandez-Salas , Joseph Francis , Shengwen Li , Marcella A. Gilmore , Kei R. Aoki
CPC分类号： C07K14/33 , C07K2319/035 , C07K2319/33 , C07K2319/50 , C07K2319/55
摘要： The specification discloses modified Clostridial toxins comprising a Clostridial toxin enzymatic domain, a Clostridial toxin translocation domain and an enhanced Clostridial toxin binding domain; polynucleotide molecules encoding such modified Clostridial toxins; and method of producing such modified Clostridial toxins.
摘要翻译： 该说明书公开了修饰梭菌毒素，其包含梭菌毒素酶促结构域，梭菌毒素易位结构域和增强的梭菌毒素结合结构域; 编码这种经修饰的梭菌毒素的多核苷酸分子; 以及生产这种经修饰的梭菌毒素的方法。
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公开(公告)号：US20090005313A1
公开(公告)日：2009-01-01
申请号：US12192419
申请日：2008-08-15
申请人： Lance E. Steward , Joseph Francis , Ester Fernandez-Salas , Marcella A. Gilmore , Shengwen Li , J. Oliver Dolly , Kei Roger Aoki
发明人： Lance E. Steward , Joseph Francis , Ester Fernandez-Salas , Marcella A. Gilmore , Shengwen Li , J. Oliver Dolly , Kei Roger Aoki
CPC分类号： C07K14/33 , A61K38/00 , C12N9/52 , Y02A50/469
摘要： Compositions comprising activatable recombinant neurotoxins and polypeptides derived therefrom. The invention also comprises nucleic acids encoding such polypeptides, and methods of making such polypeptides and nucleic acids.
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公开(公告)号：US20080161226A1
公开(公告)日：2008-07-03
申请号：US11845167
申请日：2007-08-27
申请人： Lance E. Steward , Joseph Francis , Ester Fernandez-Salas , Marcella A. Gilmore , Shengwen Li , J. Oliver Dolly , Kei Roger Aoki
发明人： Lance E. Steward , Joseph Francis , Ester Fernandez-Salas , Marcella A. Gilmore , Shengwen Li , J. Oliver Dolly , Kei Roger Aoki
CPC分类号： C07K14/33 , A61K38/00 , C12N9/52 , Y02A50/469
摘要： Compositions comprising activatable recombinant neurotoxins and polypeptides derived therefrom. The invention also comprises nucleic acids encoding such polypeptides, and methods of making such polypeptides and nucleic acids.
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4.发明申请Modified Clostridial Toxins with Enhanced Targeting Capabilities For Endogenous Clostridial Toxin Receptor Systems 有权改良梭菌毒素对内源性梭菌毒素受体系统具有增强的靶向能力公开(公告)号：US20120178140A1
公开(公告)日：2012-07-12
申请号：US13406422
申请日：2012-02-27
申请人： Lance E. Steward , Ester Fernandez-Salas , Joseph Francis , Shengwen Li , Marcella A. Gilmore , Kei Roger Aoki
发明人： Lance E. Steward , Ester Fernandez-Salas , Joseph Francis , Shengwen Li , Marcella A. Gilmore , Kei Roger Aoki
CPC分类号： C07K14/33 , C07K2319/035 , C07K2319/33 , C07K2319/50 , C07K2319/55
摘要： The specification discloses modified Clostridial toxins comprising a Clostridial toxin enzymatic domain, a Clostridial toxin translocation domain and an enhanced Clostridial toxin binding domain; polynucleotide molecules encoding such modified Clostridial toxins; and method of producing such modified Clostridial toxins.
摘要翻译： 该说明书公开了修饰梭菌毒素，其包含梭菌毒素酶促结构域，梭菌毒素易位结构域和增强的梭菌毒素结合结构域; 编码这种经修饰的梭菌毒素的多核苷酸分子; 以及生产这种经修饰的梭菌毒素的方法。
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5.发明申请Modified Clostridial Toxins with Altered Targeting Capabilities For Clostridial Toxin Target Cells 有权对梭菌毒素靶细胞具有改变的靶向能力的改良梭菌毒素公开(公告)号：US20120052548A1
公开(公告)日：2012-03-01
申请号：US13281642
申请日：2011-10-26
申请人： Lance E. Steward , Ester Fernandez-Salas , Joseph Francis , Shengwen Li , Marcella A. Gilmore , Kei Roger Aoki
发明人： Lance E. Steward , Ester Fernandez-Salas , Joseph Francis , Shengwen Li , Marcella A. Gilmore , Kei Roger Aoki
IPC分类号： C12N9/96
CPC分类号： C07K14/33 , C07K2319/035 , C07K2319/33 , C07K2319/50 , C07K2319/55
摘要： The specification discloses modified Clostridial toxins comprising a Clostridial toxin enzymatic domain, a Clostridial toxin translocation domain and an enhanced Clostridial toxin binding domain; polynucleotide molecules encoding such modified Clostridial toxins; and method of producing such modified Clostridial toxins.
摘要翻译： 该说明书公开了修饰梭菌毒素，其包含梭菌毒素酶促结构域，梭菌毒素易位结构域和增强的梭菌毒素结合结构域; 编码这种经修饰的梭菌毒素的多核苷酸分子; 以及生产这种经修饰的梭菌毒素的方法。
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公开(公告)号：US20090069238A1
公开(公告)日：2009-03-12
申请号：US12192900
申请日：2008-08-15
申请人： Lance E. Steward , Joseph Francis , Ester Fernandez-Salas , Sanjiv Ghanshani , Marcella A. Gilmore , Shengwen Li , J. Oliver Dolly , Kei Roger Aoki
发明人： Lance E. Steward , Joseph Francis , Ester Fernandez-Salas , Sanjiv Ghanshani , Marcella A. Gilmore , Shengwen Li , J. Oliver Dolly , Kei Roger Aoki
CPC分类号： C07K14/33 , A61K38/00 , C12N9/52 , Y02A50/469
摘要： Compositions comprising activatable recombinant neurotoxins and polypeptides derived therefrom. The invention also comprises nucleic acids encoding such polypeptides, and methods of making such polypeptides and nucleic acids.
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公开(公告)号：US07811584B2
公开(公告)日：2010-10-12
申请号：US12210770
申请日：2008-09-15
申请人： Lance E. Steward , Ester Fernandez-Salas , Joseph Francis , Shengwen Li , Marcella A. Gilmore , Kei Roger Aoki
发明人： Lance E. Steward , Ester Fernandez-Salas , Joseph Francis , Shengwen Li , Marcella A. Gilmore , Kei Roger Aoki
CPC分类号： A61K38/4886 , C07K14/33 , C07K2319/00 , C07K2319/035 , C07K2319/06
摘要： The present invention is directed to multivalent Clostridial toxin comprising more than one binding domain directed to a cell surface molecule of a target cell. Such modified toxins are useful as therapeutic compositions to prevent exocytosis and secretion by the target cell. Conditions in which such compositions man be useful include, without limitation, disorders of the sensory or motor nervous system, acute or chronic pain, cancer, pancreatitis, hyperhydrosis, glandular disorders, viral infections, cystic fibrosis and the like. The invention is also directed to methods of using and administering such a composition, and methods of treating a given condition using such a composition.
摘要翻译： 本发明涉及包含针对靶细胞的细胞表面分子的多于一个结合结构域的多价梭菌毒素。 这样的修饰毒素可用作治疗组合物，以防止靶细胞的胞吐作用和分泌。 这种组合物可用的条件包括但不限于感觉或运动神经系统的疾病，急性或慢性疼痛，癌症，胰腺炎，超氧化，腺体疾病，病毒感染，囊性纤维变性等。 本发明还涉及使用和施用这种组合物的方法，以及使用这种组合物治疗给定病症的方法。
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公开(公告)号：US20090018081A1
公开(公告)日：2009-01-15
申请号：US12192854
申请日：2008-08-15
申请人： Lance E. Steward , Joseph Francis , Ester Fernandez-Salas , Marcella A. Gilmore , Shengwen Li , J. Oliver Dolly , Kei Roger Aoki
发明人： Lance E. Steward , Joseph Francis , Ester Fernandez-Salas , Marcella A. Gilmore , Shengwen Li , J. Oliver Dolly , Kei Roger Aoki
IPC分类号： A61K38/16 , C07K14/00 , C07K14/655 , C07K16/00 , A61P37/02 , C12N15/64 , C07H21/00 , C12P21/00
CPC分类号： C12N9/52 , C07K14/33 , C07K14/575 , C07K14/57509 , C07K14/635 , C07K14/655 , C07K2319/035 , C07K2319/50 , C07K2319/55
摘要： Compositions comprising activatable recombinant neurotoxins and polypeptides derived therefrom. The invention also comprises nucleic acids encoding such polypeptides, and methods of making such polypeptides and nucleic acids.
摘要翻译： 包含可活化的重组神经毒素和由其衍生的多肽的组合物。 本发明还包括编码这种多肽的核酸，以及制备这种多肽和核酸的方法。
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公开(公告)号：US08071110B2
公开(公告)日：2011-12-06
申请号：US12192546
申请日：2008-08-15
申请人： Lance E. Steward , Joseph Francis , Ester Fernandez-Salas , Sanjiv Ghanshani , Marcella A. Gilmore , Shengwen Li , J. Oliver Dolly , Kei Roger Aoki
发明人： Lance E. Steward , Joseph Francis , Ester Fernandez-Salas , Sanjiv Ghanshani , Marcella A. Gilmore , Shengwen Li , J. Oliver Dolly , Kei Roger Aoki
CPC分类号： C07K14/33 , A61K38/00 , C12N9/52 , Y02A50/469
摘要： Compositions comprising activatable recombinant neurotoxins and polypeptides derived therefrom. The invention also comprises nucleic acids encoding such polypeptides, and methods of making such polypeptides and nucleic acids.
摘要翻译： 包含可活化的重组神经毒素和由其衍生的多肽的组合物。 本发明还包括编码这种多肽的核酸，以及制备这种多肽和核酸的方法。
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10.发明授权Modified clostridial toxins with altered targeting capabilities for clostridial toxin target cells 有权对梭菌毒素靶细胞具有改变的靶向能力的改良梭菌毒素公开(公告)号：US08052979B2
公开(公告)日：2011-11-08
申请号：US11817937
申请日：2006-03-14
申请人： Lance E. Steward , Ester Fernandez-Salas , Joseph Francis , Shengwen Li , Marcella A. Gilmore , Kei Roger Aoki
发明人： Lance E. Steward , Ester Fernandez-Salas , Joseph Francis , Shengwen Li , Marcella A. Gilmore , Kei Roger Aoki
CPC分类号： C07K14/33 , C07K2319/035 , C07K2319/33 , C07K2319/50 , C07K2319/55
摘要： The specification discloses modified Clostridial toxins comprising a Clostridial toxin enzymatic domain, a Clostridial toxin translocation domain and an enhanced Clostridial toxin binding domain; polynucleotide molecules encoding such modified Clostridial toxins; and method of producing such modified Clostridial toxins.
摘要翻译： 该说明书公开了修饰梭菌毒素，其包含梭菌毒素酶促结构域，梭菌毒素易位结构域和增强的梭菌毒素结合结构域; 编码这种经修饰的梭菌毒素的多核苷酸分子; 以及生产这种经修饰的梭菌毒素的方法。
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