公开(公告)号：US20140087454A1

公开(公告)日：2014-03-27

申请号：US14005563

申请日：2011-03-21

申请人： Lanjuan Li ,  Chengbo Yu ,  Yiming Zhang ,  Xiaoping Pan ,  Weibo Du ,  Hongcui Cao ,  Guoliang Lv ,  Jianrong Huang

发明人： Lanjuan Li ,  Chengbo Yu ,  Yiming Zhang ,  Xiaoping Pan ,  Weibo Du ,  Hongcui Cao ,  Guoliang Lv ,  Jianrong Huang

IPC分类号： C12N5/071

CPC分类号： C12N5/0062 ,  A61F2/022 ,  A61M1/14 ,  A61M1/3472 ,  A61M1/3489 ,  C12M3/00 ,  C12M21/08 ,  C12M25/10 ,  C12M25/14 ,  C12M29/26 ,  C12N5/067

摘要： The present invention provides a hepatic lobule-like bioreactor. The bioreactor includes a nanofiber scaffold enclosed within a housing. An intrahepatic fibrous vascular network, a bile capillary network, upper hepatic bile ducts, lower hepatic bile ducts, a common bile duct connecting the upper and the lower hepatic bile ducts, and collagen fibrous microchannels for hepatocytes surrounded by the bile capillary network are distributed throughout the nanofiber scaffold. Bile capillaries in the bile capillary network are provided with two or more inlet ports for biliary epithelial cells. The collagen fibrous microchannels for hepatocytes are provided with two or more inlet ports for hepatocytes. The intrahepatic vascular network is provided with a liquid inlet port and a liquid outlet port. These ports extend through the housing

摘要翻译： 本发明提供了一种肝小叶状生物反应器。 生物反应器包括封装在壳体内的纳米纤维支架。 肝内纤维状血管网络，胆管毛细血管网，上肝胆管，下肝胆管，连接肝胆管上胆管和胆总管的胆总管，以及胆管毛细血管网包围肝细胞的胶原纤维微通道 纳米纤维支架。 胆管毛细血管网中的胆汁毛细管具有两个或更多个用于胆管上皮细胞的入口端口。 用于肝细胞的胶原纤维微通道设置有两个或更多个用于肝细胞的入口。 肝内血管网设置有液体入口和液体出口。 这些端口延伸穿过外壳

公开(公告)号：US08735143B2

公开(公告)日：2014-05-27

申请号：US14005563

申请日：2011-03-21

申请人： Lanjuan Li ,  Chengbo Yu ,  Yiming Zhang ,  Xiaoping Pan ,  Weibo Du ,  Hongcui Cao ,  Guoliang Lv ,  Jianrong Huang

发明人： Lanjuan Li ,  Chengbo Yu ,  Yiming Zhang ,  Xiaoping Pan ,  Weibo Du ,  Hongcui Cao ,  Guoliang Lv ,  Jianrong Huang

IPC分类号： C12M3/00 ,  C12N5/00 ,  A61M1/14

CPC分类号： C12N5/0062 ,  A61F2/022 ,  A61M1/14 ,  A61M1/3472 ,  A61M1/3489 ,  C12M3/00 ,  C12M21/08 ,  C12M25/10 ,  C12M25/14 ,  C12M29/26 ,  C12N5/067

摘要： The present invention provides a hepatic lobule-like bioreactor. The bioreactor includes a nanofiber scaffold enclosed within a housing. An intrahepatic fibrous vascular network, a bile capillary network, upper hepatic bile ducts, lower hepatic bile ducts, a common bile duct connecting the upper and the lower hepatic bile ducts, and collagen fibrous microchannels for hepatocytes surrounded by the bile capillary network are distributed throughout the nanofiber scaffold. Bile capillaries in the bile capillary network are provided with two or more inlet ports for biliary epithelial cells. The collagen fibrous microchannels for hepatocytes are provided with two or more inlet ports for hepatocytes. The intrahepatic vascular network is provided with a liquid inlet port and a liquid outlet port. These ports extend through the housing.

摘要翻译： 本发明提供了一种肝小叶状生物反应器。 生物反应器包括封装在壳体内的纳米纤维支架。 肝内纤维状血管网络，胆管毛细血管网，上肝胆管，下肝胆管，连接肝胆管上胆管和胆总管的胆总管，以及胆管毛细血管网包围肝细胞的胶原纤维微通道 纳米纤维支架。 胆管毛细血管网中的胆汁毛细管具有两个或更多个用于胆管上皮细胞的入口端口。 用于肝细胞的胶原纤维微通道设置有两个或更多个用于肝细胞的入口。 肝内血管网设置有液体入口和液体出口。 这些端口延伸穿过外壳。