Chemokine receptor antagonists
    1.
    发明授权
    Chemokine receptor antagonists 有权
    趋化因子受体拮抗剂

    公开(公告)号:US06316449B1

    公开(公告)日:2001-11-13

    申请号:US09558267

    申请日:2000-04-25

    IPC分类号: A61K31150

    CPC分类号: C07D471/14

    摘要: The instant invention is a series of compounds which are MCP-1 receptor antagonists of Formula I Also included in the invention are intermediates and processes for the preparation of the compounds as well as methods of using the compounds as agents for the treatment of atherosclerosis, chronic and acute inflammatory disease, chronic and acute immune disorders and transplant rejection as well as for preventing infection by HIV, treating infection by HIV, delaying the onset of AIDS, or treating AIDS.

    摘要翻译: 本发明是一系列化合物,其是本发明中包括的式IAl的MCP-1受体拮抗剂,其是中间体和化合物的制备方法,以及使用该化合物作为治疗动脉粥样硬化,慢性和 急性炎症性疾病,慢性和急性免疫疾病和移植排斥以及预防艾滋病毒感染,治疗艾滋病毒感染,延迟艾滋病发作或治疗艾滋病。